Optogenetically-induced multimerization of the dopamine transporter increases uptake and trafficking to the plasma membrane

Autor: Christopher Anderson, Ashley M. Manson, J. Shawn Goodwin, Faisal M. Yayah, Evan G.B. Jackson, Tanu Rana, Shalonda M. Ingram, Benem-Orom Davids

Publikováno v: The Journal of Biological Chemistry

The dopamine transporter (DAT) is essential for the reuptake of the released neurotransmitter dopamine (DA) in the brain. Psychostimulants, methamphetamine and cocaine, have been reported to induce the formation of DAT multimeric complexes in vivo an

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http://europepmc.org/articles/PMC8203837

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The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.

Autor: Mziaut H; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the Univ. Hospital, Faculty of Medicine Carl Gustav Carus, Technische Univ. Dresden, 01307 Dresden, Germany; German Center for Diabetes Research (DZD e.V.), 85674 Neuherberg, Germany., Mulligan B; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the Univ. Hospital, Faculty of Medicine Carl Gustav Carus, Technische Univ. Dresden, 01307 Dresden, Germany; German Center for Diabetes Research (DZD e.V.), 85674 Neuherberg, Germany., Hoboth P; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the Univ. Hospital, Faculty of Medicine Carl Gustav Carus, Technische Univ. Dresden, 01307 Dresden, Germany; German Center for Diabetes Research (DZD e.V.), 85674 Neuherberg, Germany., Otto O; Biotechnology Center Dresden, 01307 Dresden, Germany., Ivanova A; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the Univ. Hospital, Faculty of Medicine Carl Gustav Carus, Technische Univ. Dresden, 01307 Dresden, Germany; German Center for Diabetes Research (DZD e.V.), 85674 Neuherberg, Germany., Herbig M; Biotechnology Center Dresden, 01307 Dresden, Germany., Schumann D; Boehringer Ingelheim Pharma GmbH & Co. KG. Cardiometabolic Research, 88397 Biberach, Germany., Hildebrandt T; Boehringer Ingelheim Pharma GmbH & Co. KG. Cardiometabolic Research, 88397 Biberach, Germany., Dehghany J; Helmholtz Centre for Infection Research (HZI), Braunschweig Integrated Centre for Systems Biology (BRICS), 38124 Braunschweig, Germany., Sönmez A; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the Univ. Hospital, Faculty of Medicine Carl Gustav Carus, Technische Univ. Dresden, 01307 Dresden, Germany; German Center for Diabetes Research (DZD e.V.), 85674 Neuherberg, Germany., Münster C; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the Univ. Hospital, Faculty of Medicine Carl Gustav Carus, Technische Univ. Dresden, 01307 Dresden, Germany; German Center for Diabetes Research (DZD e.V.), 85674 Neuherberg, Germany., Meyer-Hermann M; Helmholtz Centre for Infection Research (HZI), Braunschweig Integrated Centre for Systems Biology (BRICS), 38124 Braunschweig, Germany., Guck J; Biotechnology Center Dresden, 01307 Dresden, Germany., Kalaidzidis Y; Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany., Solimena M; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the Univ. Hospital, Faculty of Medicine Carl Gustav Carus, Technische Univ. Dresden, 01307 Dresden, Germany; German Center for Diabetes Research (DZD e.V.), 85674 Neuherberg, Germany; Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany. Electronic address: Michele.Solimena@tu-dresden.de.

Publikováno v: Molecular metabolism [Mol Metab] 2016 Jun 10; Vol. 5 (8), pp. 656-668. Date of Electronic Publication: 2016 Jun 10 (Print Publication: 2016).