Zobrazeno 1 - 10
of 356
pro vyhledávání: '"D, Waddell"'
Autor:
Poonam Kakade, Hina Ojha, Olawale G. Raimi, Andrew Shaw, Andrew D. Waddell, James R. Ault, Sophie Burel, Kathrin Brockmann, Atul Kumar, Mohd Syed Ahangar, Ewelina M. Krysztofinska, Thomas Macartney, Richard Bayliss, Julia C. Fitzgerald, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 12, Iss 1 (2022)
Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways. Structural studies to date have elab
Externí odkaz:
https://doaj.org/article/676e5fcd8544472ba7c52603d7ecf995
Autor:
Andrew D. Waddell, Hina Ojha, Shalini Agarwal, Christopher J. Clarke, Ana Terriente-Felix, Houjiang Zhou, Poonam Kakade, Axel Knebel, Andrew M. Shaw, Robert Gourlay, Joby Varghese, Renata F. Soares, Rachel Toth, Thomas Macartney, Patrick A. Eyers, Nick Morrice, Richard Bayliss, Alexander J. Whitworth, Claire E. Eyers, Miratul M. K. Muqit
Loss-of-function mutations in the human PINK1 kinase (hPINK1) are causative of early-onset Parkinson’s disease (PD). Activation of hPINK1 induces phosphorylated ubiquitin to initiate removal of damaged mitochondria by autophagy. Previously we solve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e00472b151d1285b844ca753507a62
https://doi.org/10.1101/2023.03.31.534916
https://doi.org/10.1101/2023.03.31.534916
Autor:
Jonathan R. Brody, Allan M. Jordan, Dominic I. James, Donald Ogilvie, Michael J. Pishvaian, Talia Golan, Kenneth P. Olive, Jordan M. Winter, Charles J. Yeo, Dikla Atias, Yulia Glick Gorman, Chani Stossel, Maria Raitses-Gurevich, Ian D. Waddell, Kate M. Smith, Cinthya Yabar Lowder, Christopher W. Schultz, Joseph Cozzitorto, Avinoam Nevler, AnnJosette Ramirez, Saswati N. Chand, Grace A. McCarthy, Lebaron C. Agostini, Aditi Jain
Supplementary Fig S7 describes western blot and RTPCR of PARG in modified shPARG cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12baac012d9c7c055a7134059d275323
https://doi.org/10.1158/0008-5472.22421175
https://doi.org/10.1158/0008-5472.22421175
Autor:
Jonathan R. Brody, Allan M. Jordan, Dominic I. James, Donald Ogilvie, Michael J. Pishvaian, Talia Golan, Kenneth P. Olive, Jordan M. Winter, Charles J. Yeo, Dikla Atias, Yulia Glick Gorman, Chani Stossel, Maria Raitses-Gurevich, Ian D. Waddell, Kate M. Smith, Cinthya Yabar Lowder, Christopher W. Schultz, Joseph Cozzitorto, Avinoam Nevler, AnnJosette Ramirez, Saswati N. Chand, Grace A. McCarthy, Lebaron C. Agostini, Aditi Jain
Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have an average survival of less than 1 year, underscoring the importance of evaluating novel targets with matched targeted agents. We recently identified that poly (ADP) ribose glycohy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2caad1a0117fff7a23cc205bcb261f20
https://doi.org/10.1158/0008-5472.c.6510855.v1
https://doi.org/10.1158/0008-5472.c.6510855.v1
Autor:
Jonathan R. Brody, Allan M. Jordan, Dominic I. James, Donald Ogilvie, Michael J. Pishvaian, Talia Golan, Kenneth P. Olive, Jordan M. Winter, Charles J. Yeo, Dikla Atias, Yulia Glick Gorman, Chani Stossel, Maria Raitses-Gurevich, Ian D. Waddell, Kate M. Smith, Cinthya Yabar Lowder, Christopher W. Schultz, Joseph Cozzitorto, Avinoam Nevler, AnnJosette Ramirez, Saswati N. Chand, Grace A. McCarthy, Lebaron C. Agostini, Aditi Jain
Supplementary Table 1 describes BRCA and KRAS status of PDX models and IC50 of PDDX-001 and olaparib in PDAC/PDX lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026a9815acebb66132a058861657f64e
https://doi.org/10.1158/0008-5472.22421172
https://doi.org/10.1158/0008-5472.22421172
Autor:
Peter A. Jones, Ashley K. Wiseman, Helai P. Mohammad, Christopher S. Kershaw, Bryan W. King, Ian D. Waddell, Thau F. Ho, Stephen B. Baylin, Morris Muliaditan, Marcus Bantscheff, Elisabeth A. Minthorn, Thilo Werner, Alan P. Graves, Wendy A. Kellner, Phil Chapman, Mehul Patel, Anthony J. Jurewicz, Allan M. Jordan, Emma E. Fairweather, Rab K. Prinjha, Nino Campobasso, Anna Rutkowska, H. Christian Eberl, Ryan G. Kruger, Charles F. McHugh, Michael T. McCabe, Kristin M. Goldberg, Jon Paul Jaworski, Christopher L. Carpenter, Michael Steidel, Stuart Paul Romeril, Dirk A. Heerding, Lourdes Rueda, David T. Fosbenner, Amy N. Taylor, Jacques Briand, Shawn W. Foley, Arthur Groy, Andrew B. Benowitz, Xiaodong Cheng, Donald J. Ogilvie, Paola Grandi, Cunyu Zhang, Mei Li, Sarath Pathuri, Aidan G. Gilmartin, Christian S. Sherk, Juan I. Luengo, Mark Cockerill, Ali Raoof, Alexandra Stowell, Kathryn Keenan, Melissa B. Pappalardi, Makda Mebrahtu, Kristen Wong, Xing Zhang, Jessica L. Handler, Roger J. Butlin, John R. Horton, Susan Merrihew, Charlotte Burt, Dean E. McNulty
Publikováno v:
Nature Cancer. 2:1002-1017
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as the cytidine analogs decitabine or azacytidine, has demonstrated clinical ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44c950954b0f6c38dfa2b274f54f21b
https://doi.org/10.1038/s43018-021-00249-x
https://doi.org/10.1038/s43018-021-00249-x
Autor:
Atul Kumar, Jevgenia Tamjar, Andrew D Waddell, Helen I Woodroof, Olawale G Raimi, Andrew M Shaw, Mark Peggie, Miratul MK Muqit, Daan MF van Aalten
Publikováno v:
eLife, Vol 6 (2017)
Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin and the Parkin ubiquitin-like (Ubl) domain v
Externí odkaz:
https://doaj.org/article/20fff1131a3e4ec08eaeefa1982c53ca
Autor:
Poulin, Paule, Austen, Lea, M. Scott, Catherine, D. Waddell, Cameron, Dixon, Elijah, Poulin, Michelle, Lafrenière, René
Publikováno v:
Journal of Health Organization and Management, 2013, Vol. 27, Issue 2, pp. 246-265.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/14777261311321806
Autor:
Atsushi Kitagawa, Ian D. Waddell, Allan M. Jordan, Sachin A. Gupte, Christina Jacob, Ivan F. McMurtry
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 377:284-292
Pulmonary hypertension (PH) is a disease of hyperplasia of pulmonary vascular cells. The pentose phosphate pathway (PPP)—a fundamental glucose metabolism pathway—is vital for cell growth. Because treatment of PH is inadequate, our goal was to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2d01fe76201f56338ee51882bc3d20
https://doi.org/10.1124/jpet.120.000166
https://doi.org/10.1124/jpet.120.000166
Autor:
Haifeng Tang, Kristian Jensen, Evelyne Houang, Fiona M. McRobb, Sathesh Bhat, Mats Svensson, Art Bochevarov, Tyler Day, Markus K. Dahlgren, Jeffery A. Bell, Leah Frye, Robert J. Skene, James H. Lewis, James D. Osborne, Jason P. Tierney, James A. Gordon, Maria A. Palomero, Caroline Gallati, Robert S. L. Chapman, Daniel R. Jones, Kim L. Hirst, Mark Sephton, Alka Chauhan, Andrew Sharpe, Piero Tardia, Elsa A. Dechaux, Andrea Taylor, Ross D. Waddell, Andrea Valentine, Holden B. Janssens, Omar Aziz, Dawn E. Bloomfield, Sandeep Ladha, Ian J. Fraser, John M. Ellard
Publikováno v:
Journal of medicinal chemistry. 65(9)
d-Serine is a coagonist of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b43e12ebdbafe3d82d1d2c444960163
https://pubmed.ncbi.nlm.nih.gov/35482677
https://pubmed.ncbi.nlm.nih.gov/35482677