Zobrazeno 1 - 10
of 3 892
pro vyhledávání: '"D, Von Hoff"'
Autor:
Andrés M. Arias-Lorza, James R. Costello, Sunil R. Hingorani, Daniel D. Von Hoff, Ronald L. Korn, Natarajan Raghunand
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Pre-clinical and clinical studies have shown that PEGPH20 depletes intratumoral hyaluronic acid (HA), which is linked to high interstitial fluid pressures and poor distribution of chemotherapies. 29 patients with metastatic advanced solid tu
Externí odkaz:
https://doaj.org/article/efc4f39a74d3420ca38b41a64d4c8737
Publikováno v:
Business Wire (English). 07/15/2024.
Autor:
Gayle S. Jameson, Peter J. Hosein, Erin Pierce, Mandana Kamgar, Michael S. Gordon, Courtney Snyder, Denise J. Roe, Betsy C. Wertheim, Marina Davey, Michael T. Barrett, Daniel D. Von Hoff, Erkut Borazanci
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Background A previous phase IB/II study of nab‐paclitaxel + cisplatin + gemcitabine (NABPLAGEM) in 25 patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC) demonstrated favorable results. This phase II study
Externí odkaz:
https://doaj.org/article/2c0e7f0b47f441ccb1349c0b69fa9034
Autor:
Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L. Truitt, Corina E. Antal, Annette R. Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F. M. Pinto, Dylan C. Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T. Yu, Tony Hunter, Dannielle D. Engle, Haiyong Han, Daniel D. Von Hoff, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetyla
Externí odkaz:
https://doaj.org/article/7cb7b07e6adf42b0aac1cff0935b9ca2
Autor:
Gabriela R. Rossi, Ashley Jensen, Serina Ng, Zhirong Yin, Aimin Li, Anjan Misra, Daniel D. Von Hoff, Lewis Gruber, Misty Gruber, Haiyong Han
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract SIWA318H is a novel monoclonal antibody that selectively targets an advanced glycation end product biomarker found in damaged/dysfunctional cells exhibiting (a) aerobic glycolysis, and (b) oxidative stress. Cells with this biomarker are dysf
Externí odkaz:
https://doaj.org/article/8d4e74ed452b4bde995297ad91a1e862
Autor:
Corina E. Antal, Tae Gyu Oh, Stefan Aigner, En-Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Zhang Cheng, Henry Jiao, Allen Wang, Nasun Hah, Elizabeth Lenkiewicz, Jan C. Lumibao, Morgan L. Truitt, Gabriela Estepa, Ester Banayo, Senada Bashi, Edgar Esparza, Ruben M. Munoz, Jolene K. Diedrich, Nicole M. Sodir, Jasmine R. Mueller, Cory R. Fraser, Erkut Borazanci, David Propper, Daniel D. Von Hoff, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Haiyong Han, Andrew M. Lowy, Michael T. Barrett, Dannielle D. Engle, Gerard I. Evan, Gene W. Yeo, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE
Externí odkaz:
https://doaj.org/article/57cc744cc0404cd39ed1bebee4e6eee7
Autor:
Wei Lin, Pawan Noel, Erkut H. Borazanci, Jeeyun Lee, Albert Amini, In Woong Han, Jin Seok Heo, Gayle S. Jameson, Cory Fraser, Margaux Steinbach, Yanghee Woo, Yuman Fong, Derek Cridebring, Daniel D. Von Hoff, Joon Oh Park, Haiyong Han
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-14 (2020)
Abstract Background Solid tumors such as pancreatic ductal adenocarcinoma (PDAC) comprise not just tumor cells but also a microenvironment with which the tumor cells constantly interact. Detailed characterization of the cellular composition of the tu
Externí odkaz:
https://doaj.org/article/8b7c0be7851a4bb292f956641870399d
Autor:
Ronald Lee Korn, Andre Burkett, Jeff Geschwind, Dominic Zygadlo, Taylor Brodie, Derek Cridebring, Daniel D. Von Hoff, Michael J. Demeure
Publikováno v:
Diagnostics, Vol 13, Iss 5, p 941 (2023)
Despite a growing number of effective therapeutic options for patients with pancreatic adenocarcinoma, the prognosis remains dismal mostly due to the late-stage presentation and spread of the cancer to other organs. Because a genomic analysis of panc
Externí odkaz:
https://doaj.org/article/cdf2491e9d484260a7e7dc7446c43c2c
Role of 3D Volumetric and Perfusion Imaging for Detecting Early Changes in Pancreatic Adenocarcinoma
Autor:
Syed Rahmanuddin, Ronald Korn, Derek Cridebring, Erkut Borazanci, Jordyn Brase, William Boswell, Asma Jamil, Wenli Cai, Aqsa Sabir, Pejman Motarjem, Eugene Koay, Anirban Mitra, Ajay Goel, Joyce Ho, Vincent Chung, Daniel D. Von Hoff
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
PurposeThere is a major shortage of reliable early detection methods for pancreatic cancer in high-risk groups. The focus of this preliminary study was to use Time Intensity-Density Curve (TIDC) and Marley Equation analyses, in conjunction with 3D vo
Externí odkaz:
https://doaj.org/article/7e5edb490b994c4494db038e364f5410
Autor:
Mohamed Zaid, Dalia Elganainy, Prashant Dogra, Annie Dai, Lauren Widmann, Pearl Fernandes, Zhihui Wang, Maria J. Pelaez, Javier R. Ramirez, Aatur D. Singhi, Anil K. Dasyam, Randall E. Brand, Walter G. Park, Syed Rahmanuddin, Michael H. Rosenthal, Brian M. Wolpin, Natalia Khalaf, Ajay Goel, Daniel D. Von Hoff, Eric P. Tamm, Anirban Maitra, Vittorio Cristini, Eugene J. Koay
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
BackgroundPreviously, we characterized subtypes of pancreatic ductal adenocarcinoma (PDAC) on computed-tomography (CT) scans, whereby conspicuous (high delta) PDAC tumors are more likely to have aggressive biology and poorer clinical outcomes compare
Externí odkaz:
https://doaj.org/article/aeb9276424164ff2ac2dcfd9ad1ed50b