Zobrazeno 1 - 10
of 97
pro vyhledávání: '"D, Vander Velde"'
Publikováno v:
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 79:503-512
The thermodynamics of binding of various neutral, cationic and anionic substrates to β-cyclodextrin, a hydroxylpropyl-β-cyclodextrin (HP4M-β-CD) and three sulfobutyl-β-cyclodextrins with varying degrees of total substitution (SBE1M-β-CD, SBE7M-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e6aa2291342b82668583b682caf508f
https://doi.org/10.1007/s10847-013-0374-2
https://doi.org/10.1007/s10847-013-0374-2
Autor:
C.R. Middaugh, Elizabeth M. Topp, Teruna J. Siahaan, C.E. Stotz, Ronald T. Borchardt, D. Vander Velde
Publikováno v:
Journal of Peptide Research. 63:371-382
A spontaneously folding beta-hairpin peptide (Lys-Lys-Tyr-Thr-Val-Ser-Ile-Asn-Gly-Lys-Lys-Ile-Thr-Val-Ser-Ile) and related cyclic (cyclo-Gly-Lys-Tyr-Ile-Asn-Gly-Lys-Ile-Ile-Asn) and linear (Ser-Ile-Asn-Gly-Lys) controls were studied to determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25652ba45d8caeb29fbd22640ef73e1e
https://doi.org/10.1111/j.1399-3011.2004.00129.x
https://doi.org/10.1111/j.1399-3011.2004.00129.x
Publikováno v:
The Journal of Peptide Research. 60:159-168
Leuprolide acetate (pGlu-His-Trp-Ser-Tyr-d-Leu-Leu-Arg-Pro-NHEt), a potent LHRH agonist in wide clinical use, was characterized conformationally by NMR and circular dichroism. It displayed quite different preferred conformations under different solut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70abc9769ee699e2c1b08f74d36415ce
https://doi.org/10.1034/j.1399-3011.2002.21006.x
https://doi.org/10.1034/j.1399-3011.2002.21006.x
Publikováno v:
The Journal of Peptide Research. 59:183-195
The coumarinic acid-based cyclic DADLE (H-Tyr-D-Ala-Gly-Phe-D-Leu-OH) prodrug 1a exhibited more favorable physicochemical properties than did DADLE for permeation across the intestinal mucosa. However, prodrug 1a, whose bioconversion to DADLE was slo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b8d8c58a942ccb3eee72bdcfa4c8802
https://doi.org/10.1034/j.1399-3011.2002.1o983.x
https://doi.org/10.1034/j.1399-3011.2002.1o983.x
Publikováno v:
The Journal of Peptide Research. 57:361-373
Peptide bond bioisosteres, such as hydroxyethylamine (Hea), have frequently been used to stabilize metabolically labile peptide bonds in peptidomimetic drug design in an effort to increase the oral bioavailability of drug candidates. However, the imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05f55df3dead922e46f24cec99e9c3d4
https://doi.org/10.1034/j.1399-3011.2001.00830.x
https://doi.org/10.1034/j.1399-3011.2001.00830.x
Autor:
Ronald T. Borchardt, D. Vander Velde, Minli Xie, Elizabeth M. Topp, Richard L. Schowen, Martha D. Morton, Jeffrey Aubé
Publikováno v:
The Journal of Peptide Research. 56:165-171
Mimetics of beta-turn structures in proteins have been used to calibrate the relative reactivities toward deamidation of asparagine residues in the two central positions of a beta-turn and in a random coil. N-Acetyl-Asn-Gly-6-aminocaproic acid, an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ab0b51bc97e0379e15edd2dea490a85
https://doi.org/10.1034/j.1399-3011.2000.00764.x
https://doi.org/10.1034/j.1399-3011.2000.00764.x
Autor:
Seetharama D. Jois, Teruna J. Siahaan, O.S. Gudmundsson, Ronald T. Borchardt, A. Bak, D. Vander Velde
Publikováno v:
The Journal of Peptide Research. 53:403-413
In an earlier study using Caco-2 cells, an in vitro cell culture model of the intestinal mucosa, we have shown that the acyloxyalkoxy-based cyclic prodrugs 3 and 4 of the opioid peptides [Leu5]-enkephalin(1, H-Tyr-GLY-Gly-Phe-Leu-OH) and DADLE(2, H-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4b9c19ee94d7a21add291099fafbbd
https://doi.org/10.1034/j.1399-3011.1999.00077.x
https://doi.org/10.1034/j.1399-3011.1999.00077.x
Autor:
Seetharama D. Jois, Valentine J. Stella, Teruna J. Siahaan, Ronald T. Borchardt, D. Vander Velde, Sanjeev Gangwar
Publikováno v:
Pharmaceutical Research. 13:1657-1662
Purpose. To determine the different conformations of the acyloxyalkoxy-linked cyclic prodrug 1 of the model hexapeptide 2 in solution and to investigate the relationship between these solution conformations and the cellular permeability characteristi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c331a0c05cfe8772e3eccb166a2f7a3
https://doi.org/10.1023/a:1016484522113
https://doi.org/10.1023/a:1016484522113
Autor:
Richard L. Schowen, C. M. Riley, J. Zhou, M. A. Mummert, D. Vander Velde, Milan Slavik, Martha D. Morton
Publikováno v:
Pharmaceutical Research. 12:1361-1370
Purpose. The purposes were to study the kinetics of hydrolysis of 2′,3′,5′-triacetyl-6-azauridine ( 1 ) in aqueous solution (µ = 0.5) and to identify the main intermediates and products of the reaction. Methods. A stability indicating isocrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16de390547bbf4c6e42d6250d716ef3
https://doi.org/10.1023/a:1016238110533
https://doi.org/10.1023/a:1016238110533
Publikováno v:
Inorganic Chemistry. 32:1689-1697
W[sub 2](O-t-Bu)[sub 6] reacts with binaphthol derivatives (H[sub 2]BINO, R = H (1); H[sub 2]Me[sub 2]BINO, R = CH[sub 3] (2)) to produce monosubstituted products of the formula (R[sub 2]BINO)W[sub 2](O-t-Bu)[sub 4]. The presence of a single product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afcb9cf8fbacb1fb39220682388026ae
https://doi.org/10.1021/ic00061a026
https://doi.org/10.1021/ic00061a026