Zobrazeno 1 - 10
of 666
pro vyhledávání: '"D, Tew"'
Autor:
Jeffrey P. Townsend, Hayley B. Hassler, April D. Lamb, Pratha Sah, Aia Alvarez Nishio, Cameron Nguyen, Alexandra D. Tew, Alison P. Galvani, Alex Dornburg
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTSuccessive waves of infection by SARS-CoV-2 have left little doubt that this virus will transition to an endemic disease. Foreknowledge of when to expect seasonal surges is crucial for healthcare and public health decision-making. However, th
Externí odkaz:
https://doaj.org/article/5f2ee80989614ff4afac3241cb961543
Autor:
Jie Zhang, Zhi-wei Ye, Paramita Chakraborty, Zhenwu Luo, John Culpepper, Muhammad Aslam, Leilei Zhang, Katarina Johansson, Jesper Z. Haeggström, Jianqiang Xu, Magnus Olsson, Danyelle M. Townsend, Shikhar Mehrotra, Ralf Morgenstern, Kenneth D. Tew
Publikováno v:
Pharmacological Research, Vol 196, Iss , Pp 106899- (2023)
While recent targeted and immunotherapies in malignant melanoma are encouraging, most patients acquire resistance, implicating a need to identify additional drug targets to improve outcomes. Recently, attention has been given to pathways that regulat
Externí odkaz:
https://doaj.org/article/5d9d42b0e955458aadc407c65b31b648
Autor:
Aslam M. A. Mazari, Leilei Zhang, Zhi-Wei Ye, Jie Zhang, Kenneth D. Tew, Danyelle M. Townsend
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 688 (2023)
In humans, the cytosolic glutathione S-transferase (GST) family of proteins is encoded by 16 genes presented in seven different classes. GSTs exhibit remarkable structural similarity with some overlapping functionalities. As a primary function, GSTs
Externí odkaz:
https://doaj.org/article/cfe3261347ef461da534d32f3bcb5e60
Autor:
G.-O. F. Gowers, S. M. Chee, D. Bell, L. Suckling, M. Kern, D. Tew, D. W. McClymont, T. Ellis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
SCRaMbLE can lead to great genetic diversity for product biosynthesis but is limited by screening methods. Here the authors develop a rapid workflow using automation, ultra-fast LC/MS and barcoded nanopore sequencing to identify best performing strai
Externí odkaz:
https://doaj.org/article/0a521b41817846ec8416988a01e7bb8f
Publikováno v:
European Journal of Engineering Education. :1-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4519c85e4b43c4755d67882e73cffe
https://doi.org/10.1080/03043797.2023.2201178
https://doi.org/10.1080/03043797.2023.2201178
Autor:
Lars Bräutigam, Jie Zhang, Kristian Dreij, Linda Spahiu, Arne Holmgren, Hiroshi Abe, Kenneth D. Tew, Danyelle M. Townsend, Michael J. Kelner, Ralf Morgenstern, Katarina Johansson
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 171-179 (2018)
We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal. To elucidate why, we used zebrafish development as a model system an
Externí odkaz:
https://doaj.org/article/6112082f1b8143d8bfa088eb5a31f32c
Autor:
Desirée Bartolini, Yanzhong Wang, Jie Zhang, Daniela Giustarini, Ranieri Rossi, Gavin Y Wang, Pierangelo Torquato, Danyelle M Townsend, Kenneth D Tew, Francesco Galli
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0205626 (2019)
2,2'-diselenyldibenzoic acid (DSBA) is a chemical probe produced to explore the pharmacological properties of diphenyldiselenide-derived agents with seleno-hormetic activity undergoing preclinical development. The present study was designed to verify
Externí odkaz:
https://doaj.org/article/b7a553f8517848bfb18d42ceb2dd368c
Autor:
Jane T. Jones, Xi Qian, Jos L.J. van der Velden, Shi Biao Chia, David H. McMillan, Stevenson Flemer, Sidra M. Hoffman, Karolyn G. Lahue, Robert W. Schneider, James D. Nolin, Vikas Anathy, Albert van der Vliet, Danyelle M. Townsend, Kenneth D. Tew, Yvonne M.W. Janssen-Heininger
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 375-382 (2016)
Nuclear Factor kappa B (NF-κB) is a transcription factor family critical in the activation of pro- inflammatory responses. The NF-κB pathway is regulated by oxidant-induced post-translational modifications. Protein S-glutathionylation, or the conju
Externí odkaz:
https://doaj.org/article/3ed60b5204d4422aa9edd41130e7d3f4
Autor:
Gavin Y. Wang, Kenneth D. Tew, Stephen P. Ethier, Bradley A. Schulte, Shenghui Qin, Aimin Yang
Additional methods on drug screen, CSC sorting, real-time PCR, flow cytometric apoptosis assay and immunohistochemical (IHC) analysis are provided.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cb22e01a55a35f775d87350ffd7c8b
https://doi.org/10.1158/0008-5472.22416513
https://doi.org/10.1158/0008-5472.22416513
Autor:
Gavin Y. Wang, Kenneth D. Tew, Stephen P. Ethier, Bradley A. Schulte, Shenghui Qin, Aimin Yang
There is mounting evidence that cancer stem-like cells (CSC) are selectively enriched in residual tumors after anticancer therapies, which may account for tumor recurrence and metastasis by regenerating new tumors. Thus, there is a critical need to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7afa65abb7a957dbd464eb1b479a2c
https://doi.org/10.1158/0008-5472.c.6509574.v1
https://doi.org/10.1158/0008-5472.c.6509574.v1