Zobrazeno 1 - 10
of 76
pro vyhledávání: '"D, Strub"'
Autor:
George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. McKeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle–specific expres
Externí odkaz:
https://doaj.org/article/af1307b64c1b4419953e38f85ed47944
Autor:
Matthew D. Strub, Shyam Ramachandran, Dmitri Y. Boudko, Ella A. Meleshkevitch, Alejandro A. Pezzulo, Aravind Subramanian, Arthur Liberzon, Robert J. Bridges, Paul B. McCray Jr.
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 240-251 (2022)
Abstract Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The common ΔF508‐CFTR mutation results in protein misfolding and proteasomal degradat
Externí odkaz:
https://doaj.org/article/118b9841113341758b26c7d71659a1be
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Background We previously reported that expression of a miR-138 mimic or knockdown of SIN3A in primary cultures of cystic fibrosis (CF) airway epithelia increased ΔF508-CFTR mRNA and protein levels, and partially restored CFTR-dependent chlo
Externí odkaz:
https://doaj.org/article/7b9ca34f3d994a4680d99ff464e34bc0
Autor:
Rachel A. Hodos, Matthew D. Strub, Shyam Ramachandran, Ella A. Meleshkevitch, Dmitri Y. Boudko, Robert J. Bridges, Joel T. Dudley, Paul B. McCray Jr.
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 5, Pp 500-510 (2021)
Abstract Rare diseases affect 10% of the first‐world population, yet over 95% lack even a single pharmaceutical treatment. In the present age of information, we need ways to leverage our vast data and knowledge to streamline therapeutic development
Externí odkaz:
https://doaj.org/article/35af72e80c624b9c9410aa56577a0eb6
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Cystic fibrosis (CF), caused by mutations to CFTR, leads to severe and progressive lung disease. The most common mutant, ΔF508-CFTR, undergoes proteasomal degradation, extinguishing its anion channel function. Numerous in vitro intervention
Externí odkaz:
https://doaj.org/article/7df26fe9ff194bfba3a28caf8cd5a311
Autor:
Matthew J. Miller, George R. Marcotte, Nathan Basisty, Cameron Wehrfritz, Zachary C. Ryan, Matthew D. Strub, Andrew T. McKeen, Jennifer I. Stern, Karl A. Nath, Blake B. Rasmussen, Andrew R. Judge, Birgit Schilling, Scott M. Ebert, Christopher M. Adams
Publikováno v:
GeroScience.
Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound functional deficits and muscle atrophy. The molecular mechanisms of skeletal muscle aging are not well understood. To better understand mechanisms of muscle aging,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d8d16ffc4ee7f2111a2d8bf44695d62
https://doi.org/10.1007/s11357-023-00772-y
https://doi.org/10.1007/s11357-023-00772-y
Autor:
Scott M Ebert, Blake B Rasmussen, Andrew R Judge, Sarah M Judge, Lars Larsson, Ronald C Wek, Tracy G Anthony, George R Marcotte, Matthew J Miller, Mark A Yorek, Adrian Vella, Elena Volpi, Jennifer I Stern, Matthew D Strub, Zachary Ryan, John J Talley, Christopher M Adams
Publikováno v:
J Nutr
Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF4 can be expressed in most if not all mammalian cell types, and it can participate in a variety of cellular res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236e79fa0970ae2554bdf964592515da
https://doi.org/10.1093/jn/nxab440
https://doi.org/10.1093/jn/nxab440
Autor:
Matthew D. Strub, Shyam Ramachandran, Dmitri Y. Boudko, Ella A. Meleshkevitch, Alejandro A. Pezzulo, Aravind Subramanian, Arthur Liberzon, Robert J. Bridges, Paul B. McCray
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 240-251 (2022)
Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The common ΔF508‐CFTR mutation results in protein misfolding and proteasomal degradation. If
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69927bce9f5a70344d83ee3912fc5e1
https://doi.org/10.1002/psp4.12751
https://doi.org/10.1002/psp4.12751
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Cystic fibrosis (CF), caused by mutations to CFTR, leads to severe and progressive lung disease. The most common mutant, ΔF508-CFTR, undergoes proteasomal degradation, extinguishing its anion channel function. Numerous in vitro interventions have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03910227046e85fcd88cafc6436a4e9
https://doi.org/10.1038/s41598-020-76347-0
https://doi.org/10.1038/s41598-020-76347-0
Autor:
Paul B. McCray, Matthew D. Strub
Publikováno v:
Genes, Vol 11, Iss 546, p 546 (2020)
Genes
Genes
Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The diversity of mutations and the multiple ways by which the protein is affected present challenges for thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bc23c42ee4c8751ebeea203376045b
https://www.mdpi.com/2073-4425/11/5/546
https://www.mdpi.com/2073-4425/11/5/546