Zobrazeno 1 - 10
of 150
pro vyhledávání: '"D, Segerbäck"'
Autor:
Clarissa Marquardt, S. Diabate, Iris Hansjosten, N. Grico, Ilona Schreck, Carsten Weiss, A. Seidel, D. Pieniazek, G. T. J. van der Horst, Franz Oesch, Barbara Oesch-Bartlomowicz, D. Segerbäck, Stefanie Bormann, D.L. Kvietkova
Publikováno v:
Oncogene, 35(7), 908-918. Nature Publishing Group
Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants, and many are potent carcinogens. Benzo[a]pyrene (B[a]P), one of the best-studied PAHs, is metabolized ultimately to the genotoxin anti-B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE). BP
Publikováno v:
Carcinogenesis. 17(7)
Glycidyl ethers are reactive epoxides used as components of a variety of epoxy materials. These compounds are known to cause allergic reactions, but since they are generally also genotoxic it would be of interest to evaluate the risk for induction of
Autor:
D, Segerbäck
Publikováno v:
IARC scientific publications. (125)
Publikováno v:
IARC scientific publications. (124)
The 32P-postlabelling technique involves many steps that need to be carefully controlled in order to obtain a reliable quantitative determination of DNA adducts. We have studied several of the parameters involved in the DNA digestion procedures as we
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 84:1-9
Methyl bromide was studied in a forward mutation system of E. coli to evaluate the relationship between dose and mutagenic response. The compound had a high toxicity and a low mutagenic efficiency, as expected from the high s value. The mutagenic eff
Autor:
Dan Hultmark, Carl Axel Wachtmeister, C.J. Calleman, Lars Ehrenberg, R. Göthe, D. Segerbäck, Siv Osterman-Golkar
Publikováno v:
Biochemical and Biophysical Research Communications. 76:259-266
Experiments with mice show that the pre-carcinogen vinyl chloride is metabolically converted to a short-lived alkylating intermediate which introduces the 2-oxoethyl group onto nucleophilic sites in DNA and proteins. The absolute and relative amounts
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 127:1-8
Ethylation of guanine-N-7 in the DNA of liver and kidney and of nucleophilic groups in hemoglobin has been studied as a measure of the in vivo dose in the mouse after i.p. administration of radiolabeled ethyl methanesulfonate (EMS). The degree of eth
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 45:175-184
Male CBA mice, exposed to air contaminated with [14C] labelled ethene, were able to metabolize this olefine to ethene oxide. The amount of epoxide formed was quantitatively determined from the degree of alkylation of cysteine and histidine in haemogl
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 49:71-82
The present study explores the possibilities of using specific amino acids in haemoglobin for tissue dosimetry of alkylating agents. The well-known directly alkylating compound methyl methanesulfonate has been used as a model compound. In one experim
Autor:
K. Svensson, Lars Ehrenberg, E. Bailey, C.J. Calleman, S Osterman-Golkar, P. B. Farmer, D. Segerbäck
Publikováno v:
Teratogenesis, Carcinogenesis, and Mutagenesis. 3:395-405
Blood samples were obtained from male Fischer 344 rats exposed to controlled air concentrations of ethylene oxide; 0, 10, 33, and 100 ppm, 6 h/day, 5 days/week, for 2 years. N tau-(2-hydroxyethyl)histidine was isolated from hemoglobin hydrolysates an