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Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Autor: Eun Young Kang, Dane Cheasley, Cecile LePage, Matthew J. Wakefield, Michelle da Cunha Torres, Simone Rowley, Carolina Salazar, Zhongyue Xing, Prue Allan, David D.L. Bowtell, Anne-Marie Mes-Masson, Diane M. Provencher, Kurosh Rahimi, Linda E. Kelemen, Peter A. Fasching, Jennifer A. Doherty, Marc T. Goodman, Ellen L. Goode, Suha Deen, Paul D.P. Pharoah, James D. Brenton, Weiva Sieh, Constantina Mateoiu, Karin Sundfeldt, Linda S. Cook, Nhu D. Le, Michael S. Anglesio, C. Blake Gilks, David G. Huntsman, Catherine J. Kennedy, Nadia Traficante, D. Bowtell, G. Chenevix-Trench, A. Green, P. Webb, A. DeFazio, D. Gertig, N. Traficante, S. Fereday, S. Moore, J. Hung, K. Harrap, T. Sadkowsky, N. Pandeya, M. Malt, A. Mellon, R. Robertson, T. Vanden Bergh, M. Jones, P. Mackenzie, J. Maidens, K. Nattress, Y.E. Chiew, A. Stenlake, H. Sullivan, B. Alexander, P. Ashover, S. Brown, T. Corrish, L. Green, L. Jackman, K. Ferguson, K. Martin, A. Martyn, B. Ranieri, J. White, V. Jayde, P. Mamers, L. Bowes, L. Galletta, D. Giles, J. Hendley, K. Alsop, T. Schmidt, H. Shirley, C. Ball, C. Young, S. Viduka, Hoa Tran, Sanela Bilic, Lydia Glavinas, Julia Brooks, R. Stuart-Harris, F. Kirsten, J. Rutovitz, P. Clingan, A. Glasgow, A. Proietto, S. Braye, G. Otton, J. Shannon, T. Bonaventura, J. Stewart, S. Begbie, M. Friedlander, D. Bell, S. Baron-Hay, A. Ferrier, G. Gard, D. Nevell, N. Pavlakis, S. Valmadre, B. Young, C. Camaris, R. Crouch, L. Edwards, N. Hacker, D. Marsden, G. Robertson, P. Beale, J. Beith, J. Carter, C. Dalrymple, R. Houghton, P. Russell, M. Links, J. Grygiel, J. Hill, A. Brand, K. Byth, R. Jaworski, P. Harnett, R. Sharma, G. Wain, B. Ward, D. Papadimos, A. Crandon, M. Cummings, K. Horwood, A. Obermair, L. Perrin, D. Wyld, J. Nicklin, M. Davy, M.K. Oehler, C. Hall, T. Dodd, T. Healy, K. Pittman, D. Henderson, J. Miller, J. Pierdes, P. Blomfield, D. Challis, R. McIntosh, A. Parker, B. Brown, R. Rome, D. Allen, P. Grant, S. Hyde, R. Laurie, M. Robbie, D. Healy, T. Jobling, T. Manolitsas, J. McNealage, P. Rogers, B. Susil, E. Sumithran, I. Simpson, K. Phillips, D. Rischin, S. Fox, D. Johnson, S. Lade, M. Loughrey, N. O'Callaghan, W. Murray, P. Waring, V. Billson, J. Pyman, D. Neesham, M. Quinn, C. Underhill, R. Bell, L.F. Ng, R. Blum, V. Ganju, I. Hammond, Y. Leung, A. McCartney, M. Buck, I. Haviv, D. Purdie, D. Whiteman, N. Zeps, Anna DeFazio, Scott Kaufmann, Michael Churchman, Charlie Gourley, Andrew N. Stephens, Nicola S. Meagher, Susan J. Ramus, Yoland C. Antill, Ian Campbell, Clare L. Scott, Martin Köbel, Kylie L. Gorringe, Georgina L. Ryland, Prue E. Allan, Kathryn Alsop, Sumitra Ananda, George Au-Yeung, Maret Böhm, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Rhiannon Dudley, Nicole Fairweather, Sian Fereday, Stephen B. Fox, Neville F. Hacker, Alison M. Hadley, Joy Hendley, Gwo-Yaw Ho, Sally M. Hunter, Tom W. Jobling, Kimberly R. Kalli, Scott H. Kaufmann, Cecile Le Page, Orla M. McNally, Jessica N. McAlpine, Linda Mileshkin, Jan Pyman, Goli Samimi, Ragwha Sharma, Ian G. Campbell

Publikováno v: Mod Pathol
Kang, E Y, Cheasley, D, Lepage, C, Wakefield, M J, Da Cunha Torres, M, Rowley, S, Salazar, C, Xing, Z, Allan, P, Bowtell, D D L, Mes-masson, A, Provencher, D M, Rahimi, K, Kelemen, L E, Fasching, P A, Doherty, J A, Goodman, M T, Goode, E L, Deen, S, Pharoah, P D P, Brenton, J D, Sieh, W, Mateoiu, C, Sundfeldt, K, Cook, L S, Le, N D, Anglesio, M S, Gilks, C B, Huntsman, D G, Kennedy, C J, Traficante, N, Defazio, A, Kaufmann, S, Churchman, M, Gourley, C, Stephens, A N, Meagher, N S, Ramus, S J, Antill, Y C, Campbell, I, Scott, C L, Köbel, M & Gorringe, K L 2020, ' Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses ', Modern Pathology . https://doi.org/10.1038/s41379-020-0618-9

TP53 mutations are implicated in the progression of mucinous borderline tumors (MBOT) to mucinous ovarian carcinomas (MOC). Optimized immunohistochemistry (IHC) for TP53 has been established as a proxy for the TP53 mutation status in other ovarian tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d1dbbb8d0c6aeaf0b4a7b60db78b77
https://doi.org/10.1038/s41379-020-0618-9

789O Neoadjuvant cemiplimab in patients (pts) with stage II–IV (M0) cutaneous squamous cell carcinoma (CSCC): Primary analysis of a phase II study

Autor: N. Gross, D.M. Miller, N. Khushanlani, V. Divi, E.S. Ruiz, E.J. Lipson, F. Meier, Y.B. Su, P.L. Swiecicki, J.L. Atlas, J.L. Geiger, A. Hauschild, J.H. Choe, B.G.M. Hughes, S-Y. Yoo, K. Fenech, M.D. Mathias, H. Han, M.G. Fury, D. Rischin

Publikováno v: Annals of Oncology. 33:S904-S905

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c379827c5bb6cf3a3e2893557c56e5f9
https://doi.org/10.1016/j.annonc.2022.07.915

Prognostic stratification of HPV-associated oropharyngeal cancer based on CD103

Autor: D, Rischin, H, Mehanna, R J, Young, M, Bressel, J, Dunn, J, Corry, P, Soni, T, Fulton-Lieuw, G, Iqbal, L, Kenny, S, Porceddu, C, Wratten, M, Robinson, B J, Solomon

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 33(8)

High CD103We pooled data from the TROG 12.01 and De-ESCALaTE randomized trials that compared CETUX/70GyRT with CIS/70GyRT in low-risk HPV-associated OPSCC: American Joint Committee on Cancer 7 stage III (excluding T1-2N1) or stage IV (excluding N2b-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdc1dd5d8b8633dfe9b5f5a52a4825e0
https://pubmed.ncbi.nlm.nih.gov/35525376

818P Phase II confirmatory study of cemiplimab (350mg IV Q3W) in patients with locally advanced or metastatic cutaneous squamous cell carcinoma (CSCC): Study 1540 Group 6

Autor: B.G.M. Hughes, J.J. Grob, S.E. Bowyer, F.L. Day, R. Ladwa, B. Stein, E. Muñoz Couselo, N. Basset-Seguin, A. Guminski, L. Mortier, A. Hauschild, M.R. Migden, C. Schmults, S-Y. Yoo, J. Booth, F. Seebach, I. Lowy, M.G. Fury, D. Rischin

Publikováno v: Annals of Oncology. 33:S921

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01fb3c6b630d149ee1288bfdfa7d7d26
https://doi.org/10.1016/j.annonc.2022.07.944