Zobrazeno 1 - 10
of 358
pro vyhledávání: '"D, Riordan"'
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107805- (2023)
Summary: Combined BRAF and MEK inhibition is an effective treatment for BRAF-mutant cutaneous melanoma. However, most patients progress on this treatment due to drug resistance. Here, we applied the Sleeping Beauty transposon system to understand how
Externí odkaz:
https://doaj.org/article/307a6faef0774c0fa828d7bf2cb30974
Autor:
Eliot Y. Zhu, Jesse D. Riordan, Marion Vanneste, Michael D. Henry, Christopher S. Stipp, Adam J. Dupuy
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract Rare gain-of-function mutations in RAC1 drive drug resistance to targeted BRAF inhibition in cutaneous melanoma. Here, we show that wildtype RAC1 is a critical driver of growth and drug resistance, but only in a subset of melanomas with elev
Externí odkaz:
https://doaj.org/article/e5fe1fcbf15a42ff9db070d5dc09d9f0
Autor:
Fumou Sun, Yan Cheng, Jesse D. Riordan, Adam Dupuy, Wendy Dubois, Michael Pisano, Jing Dong, Beverly Mock, Fenghuang Zhan, Parameswaran Hari, Siegfried Janz
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Unbiased genetic forward screening using retroviral insertional mutagenesis in a genetically engineered mouse model of human multiple myeloma may further our understanding of the genetic pathways that govern neoplastic plasma cell developmen
Externí odkaz:
https://doaj.org/article/e3500f2676bd455a95eca8832206d940
Autor:
Charlotte R. Feddersen, Lexy S. Wadsworth, Eliot Y. Zhu, Hayley R. Vaughn, Andrew P. Voigt, Jesse D. Riordan, Adam J. Dupuy
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background The introduction of genome-wide shRNA and CRISPR libraries has facilitated cell-based screens to identify loss-of-function mutations associated with a phenotype of interest. Approaches to perform analogous gain-of-function screens
Externí odkaz:
https://doaj.org/article/deb2d1614bf845a88c127a675c0779c0
Autor:
Safiyyah Ziyad, Jesse D. Riordan, Ann M. Cavanaugh, Trent Su, Gloria E. Hernandez, Georg Hilfenhaus, Marco Morselli, Kristine Huynh, Kevin Wang, Jau-Nian Chen, Adam J. Dupuy, M. Luisa Iruela-Arispe
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1211-1224 (2018)
Summary: Given its role as the source of definitive hematopoietic cells, we sought to determine whether mutations initiated in the hemogenic endothelium would yield hematopoietic abnormalities or malignancies. Here, we find that endothelium-specific
Externí odkaz:
https://doaj.org/article/a74c22f7c9d148fc88f5c03dbb005087
Autor:
Mohammed Ahmed, David Breen, Cyrus Daneshvar, William Euan Falconer, Abdul Sibly, Madeleine Hindle, Thomas W Nicholson, Ghanem Aldik, Lilanganee A Telisinghe, Richard D Riordan, Adrian Marchbank
Publikováno v:
BMJ Open Respiratory Research, Vol 6, Iss 1 (2019)
Introduction Central airway obstruction (CAO) is a life-threatening complication of lung cancer. The prevalence of CAO in lung cancer patients is unknown. We audited CAO burden to inform our local cancer service.Methods This is a cohort review of all
Externí odkaz:
https://doaj.org/article/5aacc60578f041c1b4f786d1c3be0e0b
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Oncoprints showing steatosis-associated CIS gene amplifications, deep deletions, and mutations occurring in at least 5% of all(S5), steatosis-associated(S6), and alcohol-associated(S7) TCGA HCC cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454cd20e521cb04dc3547458aa1f7623
https://doi.org/10.1158/0008-5472.22415118
https://doi.org/10.1158/0008-5472.22415118
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Supplementary tables detailing qRT-PCR primer sequences (S1), IHC antibodies (S2), and parameters for histological stain quantification (S3-6) described in methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4748c8642abdcd640f9066eead0b02
https://doi.org/10.1158/0008-5472.22415115
https://doi.org/10.1158/0008-5472.22415115
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Wnt/beta-catenin(S11) and PKA/cAMP(S12) signaling alterations in liver cancer, and transgene expression in mouse livers after PKA/shp53 injection(S13)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b0044086c645f22a82bc79a8e64022
https://doi.org/10.1158/0008-5472.22415124
https://doi.org/10.1158/0008-5472.22415124
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Tables of mice(S7); CIS genes(S8); insertions(S9); human HCC CIS gene alterations(S10); steatosis-enriched CIS(S11); pathways altered in HCC(S12-18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47c32a0e1af41d542b190be3d5477fe
https://doi.org/10.1158/0008-5472.22415112
https://doi.org/10.1158/0008-5472.22415112