Zobrazeno 1 - 10 of 648 pro vyhledávání: '"D, Purves"'
1
Akademický článek
Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Autor: Tertia D. Purves-Tyson, Amelia M. Brown, Christin Weissleder, Debora A. Rothmond, Cynthia Shannon Weickert
Publikováno v: Molecular Brain, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components. While reduced midbrain GABAergic inhibitory neurotransmission may contribute to the
Externí odkaz: https://doaj.org/article/fc6b3499f9d048d3b8fbc72a998340f8
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3
Akademický článek
Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia
Autor: Tertia D. Purves-Tyson, Kate Robinson, Amelia M. Brown, Danny Boerrigter, Helen Q. Cai, Christin Weissleder, Samantha J. Owens, Debora A. Rothmond, Cynthia Shannon Weickert
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of schizophrenia cases can be defined as having a “high inflammatory/immu
Externí odkaz: https://doaj.org/article/469da861d99b486b90ec11e5fa7102fc
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4
Akademický článek
Modelos espacialmente explícitos
Autor: M.A. Zavala, R. Díaz-Sierra, D. Purves, G.E. Zea, I.R. Urbieta
Publikováno v: Ecosistemas, Vol 15, Iss 003, Pp 89-100 (2006)
Durante la última década se ha evidenciado que además de los factores tradicionalmente considerados en ecología -recursos, condiciones e interacciones bióticas y abióticas-, la naturaleza espacial de los ecosistemas condiciona muchos de los pa
Externí odkaz: https://doaj.org/article/7a33df2be43f4316926279c9c708fa53
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5
Alterations in the kynurenine pathway and excitatory amino acid transporter-2 in depression with and without psychosis: Evidence of a potential astrocyte pathology
Autor: Samara J. Brown, Amelia M. Brown, Tertia D. Purves-Tyson, Xu-Feng Huang, Cynthia Shannon Weickert, Kelly A. Newell
Publikováno v: Journal of psychiatric research. 147
Evidence, largely obtained from peripheral studies, suggests that alterations in the kynurenine pathway contribute to the aetiology of depression and disorders involving psychosis. Stimulation of the kynurenine pathway leads to the formation of neuro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568cb10f163f0912ed095a358c776190
https://pubmed.ncbi.nlm.nih.gov/35063739
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6
Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Autor: Christin Weissleder, Cynthia Shannon Weickert, Debora A. Rothmond, Amelia M. Brown, Tertia D. Purves-Tyson
Publikováno v: Molecular Brain
Molecular Brain, Vol 14, Iss 1, Pp 1-19 (2021)
Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components. While reduced midbrain GABAergic inhibitory neurotransmission may contribute to the hyperdop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284fd0ac0118329d57fff9cf3e24e643
https://doi.org/10.1186/s13041-021-00805-7
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7
Akademický článek
Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway.
Autor: Tertia D Purves-Tyson, Samantha J Owens, Kay L Double, Reena Desai, David J Handelsman, Cynthia Shannon Weickert
Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91151 (2014)
Adolescent males have an increased risk of developing schizophrenia, implicating testosterone in the precipitation of dopamine-related psychopathology. Evidence from adult rodent brain indicates that testosterone can modulate nigrostriatal dopamine.
Externí odkaz: https://doaj.org/article/0aedeec00a99490f8a0a7b6f39096e3a
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8
Cortisol-dehydroepiandrosterone ratios are inversely associated with hippocampal and prefrontal brain volume in schizophrenia
Autor: David J. Handelsman, Ellen Ji, Cynthia Shannon Weickert, Maryanne O'Donnell, Reena Desai, Cherrie Galletly, Thomas W. Weickert, Tertia D. Purves-Tyson, Rhoshel K. Lenroot, Dennis Liu, Christopher J. White
While high levels of glucocorticoids are generally neuro-damaging, a related adrenal steroid, dehydroepiandrosterone (DHEA), has anti-glucocorticoid and neuroprotective properties. Previous work has shown increased circulating levels of DHEA and abno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d10f210ea3be3022f6bdbc202a60a43
https://doi.org/10.5167/uzh-205621
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9
Maternal immune activation with high molecular weight poly(I:C) in Wistar rats leads to elevated immune cell chemoattractants
Autor: Amelia M. Brown, Illya Conn, Danny Boerrigter, Cynthia Shannon Weickert, Tertia D. Purves-Tyson
Publikováno v: Journal of Neuroimmunology. 364:577813
Maternal immune activation (MIA) with poly(I:C) is a preclinical paradigm for schizophrenia and autism research. Methodological variations, including poly(I:C) molecular weight, contribute to inconsistencies in behavioural and molecular outcomes. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba50b93797be6135b153a11a73eb859
https://doi.org/10.1016/j.jneuroim.2022.577813
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10
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease
Autor: Bryois, J. Skene, N.G. Hansen, T.F. Kogelman, L.J.A. Watson, H.J. Liu, Z. Adan, R. Alfredsson, L. Ando, T. Andreassen, O. Baker, J. Bergen, A. Berrettini, W. Birgegård, A. Boden, J. Boehm, I. Boni, C. Boraska Perica, V. Brandt, H. Breen, G. Bryois, J. Buehren, K. Bulik, C. Burghardt, R. Cassina, M. Cichon, S. Clementi, M. Coleman, J. Cone, R. Courtet, P. Crawford, S. Crow, S. Crowley, J. Danner, U. Davis, O. de Zwaan, M. Dedoussis, G. Degortes, D. DeSocio, J. Dick, D. Dikeos, D. Dina, C. Dmitrzak-Weglarz, M. Docampo Martinez, E. Duncan, L. Egberts, K. Ehrlich, S. Escaramís, G. Esko, T. Estivill, X. Farmer, A. Favaro, A. Fernández-Aranda, F. Fichter, M. Fischer, K. Föcker, M. Foretova, L. Forstner, A. Forzan, M. Franklin, C. Gallinger, S. Gaspar, H. Giegling, I. Giuranna, J. Giusti-Rodríquez, P. Gonidakis, F. Gordon, S. Gorwood, P. Gratacos Mayora, M. Grove, J. Guillaume, S. Guo, Y. Hakonarson, H. Halmi, K. Hanscombe, K. Hatzikotoulas, K. Hauser, J. Hebebrand, J. Helder, S. Henders, A. Herms, S. Herpertz-Dahlmann, B. Herzog, W. Hinney, A. Horwood, L.J. Hübel, C. Huckins, L. Hudson, J. Imgart, H. Inoko, H. Janout, V. Jiménez-Murcia, S. Johnson, C. Jordan, J. Julià, A. Juréus, A. Kalsi, G. Kaminská, D. Kaplan, A. Kaprio, J. Karhunen, L. Karwautz, A. Kas, M. Kaye, W. Kennedy, J. Kennedy, M. Keski-Rahkonen, A. Kiezebrink, K. Kim, Y.-R. Kirk, K. Klareskog, L. Klump, K. Knudsen, G.P. La Via, M. Landén, M. Larsen, J. Le Hellard, S. Leppä, V. Levitan, R. Li, D. Lichtenstein, P. Lilenfeld, L. Lin, B.D. Lissowska, J. Luykx, J. Magistretti, P. Maj, M. Mannik, K. Marsal, S. Marshall, C. Martin, N. Mattheisen, M. Mattingsdal, M. McDevitt, S. McGuffin, P. Medland, S. Metspalu, A. Meulenbelt, I. Micali, N. Mitchell, J. Mitchell, K. Monteleone, P. Monteleone, A.M. Montgomery, G. Mortensen, P.B. Munn-Chernoff, M. Nacmias, B. Navratilova, M. Norring, C. Ntalla, I. Olsen, C. Ophoff, R. O’Toole, J. Padyukov, L. Palotie, A. Pantel, J. Papezova, H. Parker, R. Pearson, J. Pedersen, N. Petersen, L. Pinto, D. Purves, K. Rabionet, R. Raevuori, A. Ramoz, N. Reichborn-Kjennerud, T. Ricca, V. Ripatti, S. Ripke, S. Ritschel, F. Roberts, M. Rotondo, A. Rujescu, D. Rybakowski, F. Santonastaso, P. Scherag, A. Scherer, S. Schmidt, U. Schork, N. Schosser, A. Seitz, J. Slachtova, L. Slagboom, P.E. Slof-Op ‘t Landt, M. Slopien, A. Sorbi, S. Strober, M. Stuber, G. Sullivan, P. Świątkowska, B. Szatkiewicz, J. Tachmazidou, I. Tenconi, E. Thornton, L. Tortorella, A. Tozzi, F. Treasure, J. Tsitsika, A. Tyszkiewicz-Nwafor, M. Tziouvas, K. van Elburg, A. van Furth, E. Wade, T. Wagner, G. Walton, E. Watson, H. Werge, T. Whiteman, D. Widen, E. Woodside, D.B. Yao, S. Yilmaz, Z. Zeggini, E. Zerwas, S. Zipfel, S. Anttila, V. Artto, V. Belin, A.C. de Boer, I. Boomsma, D.I. Børte, S. Chasman, D.I. Cherkas, L. Christensen, A.F. Cormand, B. Cuenca-Leon, E. Davey-Smith, G. Dichgans, M. van Duijn, C. Esko, T. Esserlind, A.L. Ferrari, M. Frants, R.R. Freilinger, T. Furlotte, N. Gormley, P. Griffiths, L. Hamalainen, E. Hiekkala, M. Ikram, M.A. Ingason, A. Järvelin, M.-R. Kajanne, R. Kallela, M. Kaprio, J. Kaunisto, M. Kogelman, L.J.A. Kubisch, C. Kurki, M. Kurth, T. Launer, L. Lehtimaki, T. Lessel, D. Ligthart, L. Litterman, N. Maagdenberg, A. Macaya, A. Malik, R. Mangino, M. McMahon, G. Muller-Myhsok, B. Neale, B.M. Northover, C. Nyholt, D.R. Olesen, J. Palotie, A. Palta, P. Pedersen, L. Pedersen, N. Posthuma, D. Pozo-Rosich, P. Pressman, A. Raitakari, O. Schürks, M. Sintas, C. Stefansson, K. Stefansson, H. Steinberg, S. Strachan, D. Terwindt, G. Vila-Pueyo, M. Wessman, M. Winsvold, B.S. Zhao, H. Zwart, J.A. Agee, M. Alipanahi, B. Auton, A. Bell, R. Bryc, K. Elson, S. Fontanillas, P. Furlotte, N. Heilbron, K. Hinds, D. Huber, K. Kleinman, A. Litterman, N. McCreight, J. McIntyre, M. Mountain, J. Noblin, E. Northover, C. Pitts, S. Sathirapongsasuti, J. Sazonova, O. Shelton, J. Shringarpure, S. Tian, C. Tung, J. Vacic, V. Wilson, C. Brueggeman, L. Bulik, C.M. Arenas, E. Hjerling-Leffler, J. Sullivan, P.F. International Headache Genetics Consortium Eating Disorders Working Group of the Psychiatric Genomics Consortium
Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell trans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::8da5727df8072905eec14c2619c9f167
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3077430
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