Zobrazeno 1 - 10
of 1 043
pro vyhledávání: '"D, Otto"'
Autor:
Lauren D. Otto-Dobos, Lindsay D. Strehle, Brett R. Loman, Melina M. Seng, Sagar D. Sardesai, Nicole O. Williams, Margaret E. Gatti-Mays, Daniel G. Stover, Preeti K. Sudheendra, Robert Wesolowski, Rebecca R. Andridge, Michael T. Bailey, Leah M. Pyter
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Chemotherapy frequently causes debilitating gastrointestinal symptoms, which are inadequately managed by current treatments. Recent research indicates the gut microbiome plays a role in the pathogenesis of these symptoms. The current study a
Externí odkaz:
https://doaj.org/article/04e252979f9f4ccdb88f619c16922f89
Autor:
Chengqi Wang, Yibo Dong, Chang Li, Jenna Oberstaller, Min Zhang, Justin Gibbons, Camilla Valente Pires, Mianli Xiao, Lei Zhu, Rays H. Y. Jiang, Kami Kim, Jun Miao, Thomas D. Otto, Liwang Cui, John H. Adams, Xiaoming Liu
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Malaria remains one of the deadliest infectious diseases. Transcriptional regulation effects of noncoding variants in this unusual genome of malaria parasites remain elusive. We developed a sequence-based, ab initio deep learning framework,
Externí odkaz:
https://doaj.org/article/004e37fc75b5456aa0afc0c9d7b5baaa
Autor:
Clare Andradi-Brown, Jan Stephan Wichers-Misterek, Heidrun von Thien, Yannick D Höppner, Judith AM Scholz, Helle Hansson, Emma Filtenborg Hocke, Tim Wolf Gilberger, Michael F Duffy, Thomas Lavstsen, Jake Baum, Thomas D Otto, Aubrey J Cunnington, Anna Bachmann
Publikováno v:
eLife, Vol 12 (2024)
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the highly polymorp
Externí odkaz:
https://doaj.org/article/ee63f3338efa4b578bd3c5c0608fd5e0
Autor:
Caroline F. Simmons, Justin Gibbons, Min Zhang, Jenna Oberstaller, Camilla Valente Pires, Debora Casandra, Chengqi Wang, Andreas Seyfang, Thomas D. Otto, Julian C. Rayner, John H. Adams
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Artemisinin combination therapies (ACTs) have led to a significant decrease in Plasmodium falciparum malaria mortality. This progress is now threatened by emerging artemisinin resistance (ART-R) linked originally in SE Asia to polymorphisms
Externí odkaz:
https://doaj.org/article/c026f00fd7264522ba02acdaa84a39ae
Autor:
Caroline Simmons, Justin Gibbons, Chengqi Wang, Camilla Valente Pires, Min Zhang, Faiza Siddiqui, Jenna Oberstaller, Debora Casandra, Andreas Seyfang, Liwang Cui, Thomas D. Otto, John H. Adams
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT The implementation of artemisinin (ART) combination therapies (ACTs) has greatly decreased deaths caused by Plasmodium falciparum malaria, but increasing ACT resistance in Southeast Asia and Africa could reverse this progress. Parasite popul
Externí odkaz:
https://doaj.org/article/2ff95d3581cb4cd393c7c8a9d3bf5298
Autor:
Elinor Wing, Catherine Sutherland, Katherine Miles, David Gray, Carl S. Goodyear, Thomas D. Otto, Stefan Breusch, Graeme Cowan, Mohini Gray
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
B cells are key pathogenic drivers of chronic inflammation in rheumatoid arthritis (RA). There is limited understanding of the relationship between synovial B cell subsets and pathogenic antibody secreting cells (ASCs). This knowledge is crucial for
Externí odkaz:
https://doaj.org/article/7be81bbfafaa40f7b7970a61171c4912
Autor:
Juan F. Quintana, Praveena Chandrasegaran, Matthew C. Sinton, Emma M. Briggs, Thomas D. Otto, Rhiannon Heslop, Calum Bentley-Abbot, Colin Loney, Luis de Lecea, Neil A. Mabbott, Annette MacLeod
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Detailed insight into how the brain responds to Trypanosoma brucei infection is lacking. Here, single cell and spatial transcriptomics are integrated to characterise this response, identifying a unique crosstalk between microglia and plasma cells.
Externí odkaz:
https://doaj.org/article/20ce49abd0174cbcba8717412cc4cc41
Autor:
C. N. Gutekunst, S. Liebner, A.-K. Jenner, K.-H. Knorr, V. Unger, F. Koebsch, E. D. Racasa, S. Yang, M. E. Böttcher, M. Janssen, J. Kallmeyer, D. Otto, I. Schmiedinger, L. Winski, G. Jurasinski
Publikováno v:
Biogeosciences, Vol 19, Pp 3625-3648 (2022)
Rewetted peatlands can be a significant source of methane (CH4), but in coastal ecosystems, input of sulfate-rich seawater could potentially mitigate these emissions. The presence of sulfate as an electron acceptor during organic matter decomposition
Externí odkaz:
https://doaj.org/article/e8700ba45ec3404b97b6cfaf517daa65
Autor:
Jyotsna Chawla, Ilana Goldowitz, Jenna Oberstaller, Min Zhang, Camilla Valente Pires, Francesca Navarro, Lauriane Sollelis, Chengqi C. Q. Wang, Andreas Seyfang, Jeffrey Dvorin, Thomas D. Otto, Julian C. Rayner, Matthias Marti, John H. Adams
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Transmission of the deadly malaria parasite Plasmodium falciparum from humans to mosquitoes is achieved by specialized intraerythrocytic sexual forms called gametocytes. Though the crucial regulatory mechanisms leading to gametocyte commitme
Externí odkaz:
https://doaj.org/article/ebea4ef831464fd79e290f35aa33e43a
Autor:
Camilla Valente Pires, Jenna Oberstaller, Chengqi Wang, Debora Casandra, Min Zhang, Jyotsna Chawla, Swamy Rakesh Adapa, Thomas D. Otto, Michael T. Ferdig, Julian C. Rayner, Rays H. Y. Jiang, John H. Adams
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT The antimalarial activity of the frontline drug artemisinin involves generation of reactive oxygen species (ROS) leading to oxidative damage of parasite proteins. To achieve homeostasis and maintain protein quality control in the overwhelmed
Externí odkaz:
https://doaj.org/article/9413a8d85df74786a63a64dc93cec61b