Interspecies co-feeding transmission of Powassan virus between a native tick, Ixodes scapularis, and the invasive East Asian tick, Haemaphysalis longicornis

Autor: Clemence Obellianne, Parker D. Norman, Eliane Esteves, Meghan E. Hermance

Publikováno v: Parasites & Vectors, Vol 17, Iss 1, Pp 1-15 (2024)

Abstract Background Powassan virus, a North American tick-borne flavivirus, can cause severe neuroinvasive disease in humans. While Ixodes scapularis are the primary vectors of Powassan virus lineage II (POWV II), also known as deer tick virus, recen

Externí odkaz: https://doaj.org/article/e500b0143478490e81ed346f0b7dea18

Novel Autotaxin Inhibitor ATX-1d Significantly Enhances Potency of Paclitaxel—An In Silico and In Vitro Study

Autor: Prateek Rai, Christopher J. Clark, Carl B. Womack, Curtis Dearing, Joshua Thammathong, Derek D. Norman, Gábor J. Tigyi, Subhabrata Sen, Kevin Bicker, April M. Weissmiller, Souvik Banerjee

Publikováno v: Molecules, Vol 29, Iss 18, p 4285 (2024)

The development of drug resistance in cancer cells poses a significant challenge for treatment, with nearly 90% of cancer-related deaths attributed to it. Over 50% of ovarian cancer patients and 30–40% of breast cancer patients exhibit resistance t

Externí odkaz: https://doaj.org/article/bf841400ad284582bba1e29114da38e0

Rates of Asymptomatic COVID-19 Infection and Associated Factors in Olmsted County, Minnesota, in the Prevaccination Era

Autor: Celine M. Vachon, PhD, Aaron D. Norman, MPH, Kavita Prasad, MD, Dan Jensen, MPH, Gavin M. Schaeferle, BA, Kristy L. Vierling, MA, Meaghan Sherden, MPH, Michelle R. Majerus, MBA, FACHE, Katherine A. Bews, BA, Ethan P. Heinzen, MS, Amy Hebl, BS, Kathleen J. Yost, PhD, Richard B. Kennedy, PhD, Elitza S. Theel, PhD, Aditya Ghosh, MD, Meghan Fries, Chung-Il Wi, MD, Young J. Juhn, MD, Priya Sampathkumar, MD, William G. Morice, II, MD, PHD, Walter A. Rocca, MD, MPH, Aaron J. Tande, MD, James R. Cerhan, MD, PhD, Andrew H. Limper, MD, Henry H. Ting, MD, Gianrico Farrugia, MD, Rickey E. Carter, PhD, Lila J. Finney Rutten, PhD, Robert M. Jacobson, MD, Jennifer St. Sauver, PhD

Publikováno v: Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 6, Iss 6, Pp 605-617 (2022)

Objective: To estimate rates and identify factors associated with asymptomatic COVID-19 in the population of Olmsted County during the prevaccination era. Patients and Methods: We screened first responders (n=191) and Olmsted County employees (n=564)

Externí odkaz: https://doaj.org/article/21c1135734ae4447b5f6c7a5b431ab7e

The association between genetically elevated polyunsaturated fatty acids and risk of cancerResearch in context

Autor: Philip C. Haycock, Maria Carolina Borges, Kimberley Burrows, Rozenn N. Lemaitre, Stephen Burgess, Nikhil K. Khankari, Konstantinos K. Tsilidis, Tom R. Gaunt, Gibran Hemani, Jie Zheng, Therese Truong, Brenda M. Birmann, Tracy OMara, Amanda B. Spurdle, Mark M. Iles, Matthew H. Law, Susan L. Slager, Fatemeh Saberi Hosnijeh, Daniela Mariosa, Michelle Cotterchio, James R. Cerhan, Ulrike Peters, Stefan Enroth, Puya Gharahkhani, Loic Le Marchand, Ann C. Williams, Robert C. Block, Christopher I. Amos, Rayjean J. Hung, Wei Zheng, Marc J. Gunter, George Davey Smith, Caroline Relton, Richard M. Martin, Nathan Tintle, Terri Rice, Iona Cheng, Mark Jenkins, Steve Gallinger, Alex J. Cornish, Amit Sud, Jayaram Vijayakrishnan, Margaret Wrensch, Mattias Johansson, Aaron D. Norman, Alison Klein, Alyssa Clay-Gilmour, Andre Franke, Andres V. Ardisson Korat, Bill Wheeler, Björn Nilsson, Caren Smith, Chew-Kiat Heng, Ci Song, David Riadi, Elizabeth B. Claus, Eva Ellinghaus, Evgenia Ostroumova, Hosnijeh, Florent de Vathaire, Giovanni Cugliari, Giuseppe Matullo, Irene Oi-Lin Ng, Jeanette E. Passow, Jia Nee Foo, Jiali Han, Jianjun Liu, Jill Barnholtz-Sloan, Joellen M. Schildkraut, John Maris, Joseph L. Wiemels, Kari Hemminki, Keming Yang, Lambertus A. Kiemeney, Lang Wu, Laufey Amundadottir, Marc-Henri Stern, Marie-Christine Boutron, Mark Martin Iles, Mark P. Purdue, Martin Stanulla, Melissa Bondy, Mia Gaudet, Lenha Mobuchon, Nicola J. Camp, Pak Chung Sham, Pascal Guénel, Paul Brennan, Philip R. Taylor, Quinn Ostrom, Rachael Stolzenberg-Solomon, Rajkumar Dorajoo, Richard Houlston, Robert B. Jenkins, Sharon Diskin, Sonja I. Berndt, Spiridon Tsavachidis, Stephen J. Channock, Tabitha Harrison, Tessel Galesloot, Ulf Gyllensten, Vijai Joseph, Y. Shi, Wenjian Yang, Yi Lin, Stephen K. Van Den Eeden

Publikováno v: EBioMedicine, Vol 91, Iss , Pp 104510- (2023)

Summary: Background: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. Methods: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cance

Externí odkaz: https://doaj.org/article/89940d7363ce43c781ea8d5c3c0a79fa

Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study

Autor: Paloma García-Martín, Ana Moñiz Díez, José Manuel Sánchez Maldonado, Antonio José Cabrera Serrano, Rob ter Horst, Yolanda Benavente, Stefano Landi, Angelica Macauda, Alyssa Clay-Gilmour, Francisca Hernández-Mohedo, Yasmeen Niazi, Pedro González-Sierra, Blanca Espinet, Juan José Rodríguez-Sevilla, Rossana Maffei, Gonzalo Blanco, Matteo Giaccherini, Anna Puiggros, James Cerhan, Roberto Marasca, Marisa Cañadas-Garre, Miguel Ángel López-Nevot, Tzu Chen-Liang, Hauke Thomsen, Irene Gámez, Víctor Moreno, Rafael Marcos-Gragera, María García-Álvarez, Javier Llorca, Andrés Jerez, Sonja Berndt, Aleksandra Butrym, Aaron D. Norman, Delphine Casabonne, Mario Luppi, Susan L. Slager, Kari Hemminki, Yang Li, Miguel Alcoceba, Daniele Campa, Federico Canzian, Silvia de Sanjosé, Asta Försti, Mihai G. Netea, Manuel Jurado, Juan Sainz

Publikováno v: Blood Cancer Journal, Vol 12, Iss 5, Pp 1-6 (2022)

Externí odkaz: https://doaj.org/article/d236457e4d52430a8d875808f2daf6c6