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Autor:
Anita Aperia, Gianni Celsi, Søren Nielsen, D. Marples, Roger Belusa, Ann-Christine Eklöf, Masato Yasui
Publikováno v:
American Journal of Physiology-Renal Physiology. 271:F461-F468
The capacity to concentrate urine develops progressively during postnatal life in most mammalian species. Here we have examined whether low expression of the arginine vasopressin (AVP)-activated water channel aquaporin-2 (AQP-2) may be a limiting fac
Autor:
M A, Knepper, J B, Wade, J, Terris, C A, Ecelbarger, D, Marples, B, Mandon, C L, Chou, B K, Kishore, S, Nielsen
Publikováno v:
Kidney International. 49:1712-1717
Renal aquaporins. Aquaporins (AQPs) are a newly recognized family of transmembrane proteins that function as molecular water channels. At least four aquaporins are expressed in the kidney where they mediate rapid water transport across water-permeabl
Publikováno v:
American Journal of Physiology-Renal Physiology. 269:F775-F785
The aquaporins are a family of transmembrane proteins that function as molecular water channels. Recently, a mercurial-insensitive water channel [MIWC or aquaporin-4 (AQP4)] has been cloned, and its mRNA was found to be expressed strongly in kidney i
Autor:
Søren Nielsen, James Terris, Gustavo Frindt, D Marples, Carolyn A. Ecelbarger, Mark A. Knepper, Miriam Echevarría
Publikováno v:
ResearcherID
The aquaporins are a family of water channels expressed in several water-transporting tissues, including the kidney. We have used a peptide-derived, affinity-purified polyclonal antibody to aquaporin-3 (AQP-3) to investigate its localization and regu
Publikováno v:
Experimental Physiology. 79:775-795
Vasopressin stimulates transepithelial water flow in the toad urinary bladder. We report here that N-ethyl maleimide (NEM) (0.1 mM) produces a similar increase in osmotic water flow when applied to the mucosal surface of the tissue. NEM-induced water
Publikováno v:
Histology and histopathology. 19(2)
Recent studies have shown that aquaporin water channels are expressed in human Meckel's cartilage. The aim of the present investigation was to determine if human articular chondrocytes and synoviocytes express aquaporin 1 (AQP1) water channels and to
Publikováno v:
Proceedings of the Association of American Physicians. 110(5)
A series of recent studies have demonstrated that expression of aquaporin-2 (AQP2), the vasopressin-regulated water channel of the kidney collecting duct, is greatly reduced in acquired forms of nephrogenic diabetes insipidus (NDI). In some forms of
Autor:
Jens Christian Djurhuus, D Marples, M A Knepper, Birgitte Mønster Christensen, Jørgen Frøkiær, Søren Nielsen, Uffe Birk Jensen
Publikováno v:
Aarhus University
Frøkiaer, J, Christensen, B M, Marples, D, Djurhuus, J C, Jensen, U B, Knepper, M A & Nielsen, S 1997, ' Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction ', American Journal of Physiology (Consolidated), vol. 273, no. 2 Pt 2, pp. F213-23 .
Scopus-Elsevier
Frøkiaer, J, Christensen, B M, Marples, D, Djurhuus, J C, Jensen, U B, Knepper, M A & Nielsen, S 1997, ' Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction ', American Journal of Physiology (Consolidated), vol. 273, no. 2 Pt 2, pp. F213-23 .
Scopus-Elsevier
In bilateral ureteral obstruction, both aquaporin-2 (AQP2) levels and urinary concentrating capacity are markedly reduced. However, the mechanisms involved in AQP2 downregulation are unknown. In rats with unilateral ureteral obstruction (UUO) the rel
Publikováno v:
The American journal of physiology. 270(4 Pt 2)
Polyuria after release of bilateral ureteral obstruction (BUO) is frequently seen in patients with urological disorders. In this study, we examined the effect of BUO and release of BUO on the expression of the vasopressin-regulated water channel aqua