Výsledky vyhledávání

Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells

Autor: D Mangoura, Y Sun, D. Singh, David H. Gutmann, M Ahmed, Adrian G. Flores, G Vallianatos, C Li

Publikováno v: Oncogene. 25:735-745

Children with neurofibromatosis (NF1) typically develop central nervous system (CNS) abnormalities, including aberrant proliferation of astrocytes and formation of benign astrocytomas. The NF1 gene encodes neurofibromin, a Ras-GAP, highly expressed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bdce7f36975ea257da63610ae8ec57
https://doi.org/10.1038/sj.onc.1209113

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Akademický článek

Modulation of Inflammation and Regeneration in the Intervertebral Disc Using Enhanced Cell‐Penetrating Peptides for MicroRNA Delivery.

Autor: Barcellona, Marcos N.^1,2 (AUTHOR), Ní Néill, Tara^1,2 (AUTHOR), O'Brien, Fergal J.^1,2,3 (AUTHOR), Dixon, James E.^4,5 (AUTHOR), Curtin, Caroline M.^1,2,3 (AUTHOR), Buckley, Conor T.^1,2,3 (AUTHOR) conor.buckley@tcd.ie

Publikováno v: Advanced Nanobiomed Research. Jul2024, Vol. 4 Issue 7, p1-11. 11p.

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Transient suppression of cortactin ectopically induces large telencephalic neurons towards a GABAergic phenotype

Autor: D. Mangoura, Y. Cheng, S. Leung

Publikováno v: Journal of cell science. 113

Excitatory and inhibitory neuronal cell fates require specific expression of both neurotransmitter and morphological phenotypes. The role of the F-actin cytoskeleton in morphological phenotypes has been well documented, but its role in neurotransmitt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6cd4501c0db24e01a45b920cbb4ae7
https://pubmed.ncbi.nlm.nih.gov/10954415

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Diversity of the endogenous opioid system in development. Novel signal transduction translates multiple extracellular signals into neural cell growth and differentiation

Autor: K F, Hauser, D, Mangoura

Publikováno v: Perspectives on developmental neurobiology. 5(4)

This review explores the role of individual opioid receptor types and signal transduction pathways on cell growth and differentiation. The findings reviewed herein provide suggestive evidence that while no single opioid receptor or peptide type exclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66ba2faccd59ccb80a88d08f00fb60fe
https://pubmed.ncbi.nlm.nih.gov/10533530

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mu-Opioids activate tyrosine kinase focal adhesion kinase and regulate cortical cytoskeleton proteins cortactin and vinculin in chick embryonic neurons

Autor: D, Mangoura

Publikováno v: Journal of neuroscience research. 50(3)

We have investigated the signal transduction pathway of the G-protein mu-opioid receptor upstream of phospholipase D (PLD) and protein kinase C-epsilon (PKC-epsilon) activation in postmitotic E6CH chick embryo cortical neurons. The mu-opioid receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7de0e1ef32a52a3f30fa89e850b511d8
https://pubmed.ncbi.nlm.nih.gov/9364324

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Plasticity in astrocytic phenotypes. A role for protein kinase C, tyrosine kinases, and cytoskeleton signaling

Autor: D, Mangoura, C, Pelletiere, D, Wang, N, Sakellaridis, V, Sogos

Publikováno v: Advances in experimental medicine and biology. 429

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::318e03942b371e9746f651e03bb3e49b
https://pubmed.ncbi.nlm.nih.gov/9413564

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Brain aggrecan

Autor: N B, Schwartz, M, Domowicz, R C, Krueger, H, Li, D, Mangoura

Publikováno v: Perspectives on developmental neurobiology. 3(4)

During development, the extracellular matrix (ECM) is a complex dynamic structure whose components and organization help to establish the requisite position and state of differentiation. Until recently, the large chondroitin sulfate proteoglycan, agg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a9ccc51cc90c90954398c5b1643a7ba
https://pubmed.ncbi.nlm.nih.gov/9117261

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Developmental expression of S103L cross-reacting proteoglycans in embryonic chick

Autor: N B, Schwartz, A K, Hennig, R C, Krueger, M, Krzystolik, H, Li, D, Mangoura

Publikováno v: Progress in clinical and biological research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::720ba7c338df889f81cc792bb228105d
https://pubmed.ncbi.nlm.nih.gov/8115367

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Chondroitin sulfate proteoglycan expression during neuronal development

Autor: A, Hennig, R, Krueger, D, Mangoura, N B, Schwartz

Publikováno v: Cellular and molecular biology (Noisy-le-Grand, France). 38(5-6)

Proteoglycans of developing chick brain were distinguished on the basis of reactivity with four well characterized antibody reagents (S103L, to the CS-rich domain; HNK-1, to 6-sulfated glucuronic acid; 1-C-3, to the HABr region and 5-D-4, to KS chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6c7da1c5802aeb2500068ac2bd471e5
https://pubmed.ncbi.nlm.nih.gov/1282844

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