Zobrazeno 1 - 10
of 272
pro vyhledávání: '"D, Maines"'
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Insulin’s stimulation of glucose uptake by binding to the IRK extracellular domain is compromised in diabetes. We have recently described an unprecedented approach to stimulating glucose uptake. KYCCSRK (P2) peptide, corresponding to the C-terminal
Externí odkaz:
https://doaj.org/article/41d9aab1883c41f78eab8c87505c9132
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Biliverdin reductase (BVR) is a multifunctional protein that is the primary source of the potent antioxidant, bilirubin. BVR regulates activities/functions in the insulin/IGF-1/IRK/PI3K/MAPK pathways. Activation of certain kinases in these pathways i
Externí odkaz:
https://doaj.org/article/be6092f85eed4d778ed1206b2eaa7058
Autor:
Mahin D. Maines
his book provides a comprehensive summary of data from basic research on characterization, regulation, and function of heme oxygenase in mammalian systems. The book also includes a major section that covers the currently used clinical methods to supp
Autor:
Jaime eKapitulnik, Mahin D Maines
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Externí odkaz:
https://doaj.org/article/99e13be56c6547e68c92fb35b55cdb5a
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
The expanse of human biliverdin reductase (hBVR) functions in the cells is arguably umatched by any single protein. hBVR is a Ser/Thr/Tyr kinase, a scaffold protein, a transcription factor and an intracellular transporter of gene regulators. hBVR is
Externí odkaz:
https://doaj.org/article/aaaf70d2cc8e405eb72e8c19ad8fe6ce
Autor:
Patrick D. Maines
Publikováno v:
Radio Active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c9c2906737ee71c12bcac93789e8eed
https://doi.org/10.2307/j.ctvpg85h7.10
https://doi.org/10.2307/j.ctvpg85h7.10
Autor:
Walter A. Szarek, Kanji Nakatsu, Terence R.S. Ozolinš, Mona N. Rahman, Mahin D. Maines, Zongchao Jia, Dragic Vukomanovic
Publikováno v:
Medical Gas Research, Vol 6, Iss 1, Pp 10-13 (2016)
Medical Gas Research
Medical Gas Research
Reactive thiols of cysteine (cys) residues in proteins play a key role in transforming chemical reactivity into a biological response. The heme oxygenase-2 (HO-2) isozyme contains two cys residues that have been implicated in binding of heme and also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff129a64d82e0c4f3caed8ba9dc0093
http://www.medgasres.com/article.asp?issn=2045-9912
http://www.medgasres.com/article.asp?issn=2045-9912
Autor:
Nicole Lerner-Marmarosh, Mahin D. Maines, Peter E. M. Gibbs, Tihomir Miralem, Chelsea Heimiller, Jermaine L. Jenkins
Biliverdin reductase A (BVR) and Akt isozymes have overlapping pleiotropic functions in the insulin/PI3K/MAPK pathway. Human BVR (hBVR) also reduces the hemeoxygenase activity product biliverdin to bilirubin and is directly activated by insulin recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba2e40fbd1dcf79a1a11c796cb9dc23
https://europepmc.org/articles/PMC4970609/
https://europepmc.org/articles/PMC4970609/
Autor:
Nicole Lerner-Marmarosh, Mahin D. Maines, Fred K. Hagen, Tihomir Miralem, Cicerone Tudor, Peter E. M. Gibbs
Publikováno v:
Journal of Biological Chemistry. 287:24698-24712
PKCδ, a Ser/Thr kinase, promotes cell growth, tumorigenesis, and apoptosis. Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase, inhibits apoptosis by reducing biliverdin-IX to antioxidant bilirubin. The enzymes are activated by similar stimuli.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0927d0ea12870debb4d079d0b8162bc
https://doi.org/10.1074/jbc.m111.326504
https://doi.org/10.1074/jbc.m111.326504
Autor:
Mahin D. Maines
Publikováno v:
Current Drug Targets. 11:1586-1594
The range and diversity of functions of biliverdin reductase (BVR) are unmatched by any enzyme characterized to date. BVR is the sole catalyst for the conversion of biliverdin-IXα, the activity product of the stress-inducible HO-1 and the constituti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fad73a54cffa160e9dc56a82c59b46
https://doi.org/10.2174/1389450111009011586
https://doi.org/10.2174/1389450111009011586