Zobrazeno 1 - 10
of 756
pro vyhledávání: '"D, Lesieur"'
Publikováno v:
Journal of Pineal Research. 29:116-124
Melatonin is synthesized during the night by the pineal gland. Recently, melatonin binding sites have been identified in the gut. Despite few studies, the physiological role of melatonin in gut function remains unclear. The objective of the present s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::799c5a08d19656f9cb490d3edbea8fd2
https://doi.org/10.1034/j.1600-079x.2000.290208.x
https://doi.org/10.1034/j.1600-079x.2000.290208.x
5-Halobenzothiophene Analogues of Melatonin: Synthesis and Affinity for mt1 and MT2 Receptors in Man
Autor:
Caroline Bennejean, P. Depreux, Philippe Delagrange, V. Leclerc, D. Lesieur, J. Boutin, N. Beaurain
Publikováno v:
Pharmacy and Pharmacology Communications. 6:61-65
A novel series of melatonin analogues based on the benzothiophene nucleus is described. In these compounds the methoxy group was replaced by electron-attracting groups such halogens (Br and Cl) with the aim of supplementing structure-affinity relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6132ffd3f1b846ebd4adf3ec25a557d
https://doi.org/10.1211/146080800128735647
https://doi.org/10.1211/146080800128735647
Publikováno v:
Electronic Journal of Theoretical Chemistry. 2:206-214
SUMMARY The spatial conformations of two diastereoisomers of the tripeptide N-Z-N-Bz-Lys-Ala-Sar-OBzl have been investigated by vibrational spectroscopies. It has been shown that the conformers contain a permanent hydrogenbonded C7-like structure and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18e71cfd21c3f874fbd6f7fe0f6f444
https://doi.org/10.1002/ejtc.47
https://doi.org/10.1002/ejtc.47
Publikováno v:
Electronic Journal of Theoretical Chemistry. 2:195-205
SUMMARY The tripeptide N-Z-N-Bz-Lys-Ala-Sar-OBzl is an antagonist of substance P at the human NK1 receptor, with a low affinity constant (< 1m). In this paper, we have carried out a theoretical conformational study of its diastereoisomers (S;S )a nd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae57d57dc347365a32fb364d4051253
https://doi.org/10.1002/ejtc.46
https://doi.org/10.1002/ejtc.46
Autor:
Nicole Cotelle, Jean-Charles Fruchart, Z. Moussavi, M.-O. Plancke, P. Depreux, D. Lesieur, J. Sauzieres
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b69906fb71dc80b9f5114d49f5300059
https://doi.org/10.1002/chin.199144214
https://doi.org/10.1002/chin.199144214
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d07abb2c3e14c9fe0c7cbff3b6488ac6
https://doi.org/10.1002/chin.199534128
https://doi.org/10.1002/chin.199534128
Autor:
D. H. Caignard, D. Lesieur, Morgan P, B. Guardiola‐Lemaitre, Veronique Leclerc, Patrick Depreux, Philippe Delagrange, P. Renard
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdb7a0d50156bedfcf9fcc7941326675
https://doi.org/10.1002/chin.199637311
https://doi.org/10.1002/chin.199637311
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae60a4a3ed5937be662bf0b4b030f4dd
https://doi.org/10.1002/chin.199623090
https://doi.org/10.1002/chin.199623090
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 48:1243-1246
C 27 H 28 N 2 O 4 cristallise dans P2 1 /n avec a = 7,961, b = 11,863 et c = 24,873 A, β = 92,29 °, Z = 4; affinement jusqu'a R = 0,041. Le compose du titre, obtenu sous forme de racemate, peut etre considere comme un analogue structural du trimeto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30cf88610eb9316d695cd6cb659c5c86
https://doi.org/10.1107/s0108270191013720
https://doi.org/10.1107/s0108270191013720
Autor:
H A Mansour, J. A. Berger, M Bastide, C Lartigue, J Petit, D Lesieur, J L Chabard, H. Bargnoux, N Buch
Publikováno v:
Biological Mass Spectrometry. 20:484-492
The biotransformation of 6-benzoyl benzoxazolinone (6-BB), a non-narcotic peripheral analgesic, was studied in eight healthy volunteers after oral administration of a single dose of 1 g. Urinary metabolites were extracted either with ethyl acetate at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49027de26a59e1195e7e4879c92d23c0
https://doi.org/10.1002/bms.1200200809
https://doi.org/10.1002/bms.1200200809