Zobrazeno 1 - 10
of 28
pro vyhledávání: '"D, Leisten"'
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101262- (2022)
Summary: Mitochondria-lysosome contact sites are critical for maintaining cellular homeostasis by regulating mitochondrial and lysosomal network dynamics and mediating metabolite exchange. Here, we present a protocol to quantitatively analyze the for
Externí odkaz:
https://doaj.org/article/6b4289eae97642518eaee97598e88783
Autor:
Yanan Chen, Songhua Quan, Vaibhav Patil, Rejani B. Kunjamma, Haley M. Tokars, Eric D. Leisten, Godwin Joy, Samantha Wills, Jonah R. Chan, Yvette C. Wong, Brian Popko
Publikováno v:
Glia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45b305e8953c1ea763c247af88c4767e
https://doi.org/10.1002/glia.24386
https://doi.org/10.1002/glia.24386
Publikováno v:
ACS Chemical Biology. 15:1487-1496
Proteolysis targeting chimeras (PROTACs) have emerged as useful chemical probes and potential therapeutics by taking advantage of the ubiquitin-proteasome system to degrade intracellular disease-associated proteins. PROTACs are heterobifunctional mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49367bc911d818d742541ec675560a55
https://doi.org/10.1021/acschembio.0c00140
https://doi.org/10.1021/acschembio.0c00140
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2493-2497
Histone deacetylases (HDACs) decrease the acetylation level of histones and other non-histone proteins. Over expression of HDACs have been observed in cancers and other diseases. Targeted protein degradation by "hijacking" the natural ubiquitin-prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efad44bf7a149b0057113754e5a561b
https://doi.org/10.1016/j.bmcl.2018.05.057
https://doi.org/10.1016/j.bmcl.2018.05.057
Autor:
Hao Wu, Weiping Tang, Zhongrui Zhang, Michael D Cunningham, Binkai Liu, Ka Yang, Eric D Leisten, Jing Zhang, Zhi Wen, Xueqing Nie
Publikováno v:
ACS Med Chem Lett
[Image: see text] Histone deacetylase 6 (HDAC6) is involved in multiple cellular processes such as aggresome formation, protein stability, and cell motility. Numerous HDAC6-selective inhibitors have been developed as cellular chemical tools to elucid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb519ecf098131f3af2f5ff0446af2d
https://pubmed.ncbi.nlm.nih.gov/32292566
https://pubmed.ncbi.nlm.nih.gov/32292566
Autor:
Haibo Xie, Ziyuan Li, Eric D Leisten, Cyril Barinka, Jin Liu, Zhongrui Zhang, Ka Yang, Kerry A. Smith, Hao Wu, Weiping Tang, Zora Novakova
Publikováno v:
Journal of medicinal chemistry. 62(15)
Histone deacetylase 6 (HDAC6) primarily catalyzes the removal of acetyl group from the side chain of acetylated lysine residues in cytoplasmic proteins such as α-tubulin and HSP90. HDAC6 is involved in multiple disease-relevant pathways. Based on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d31f41d1f1e75bc3287c1004cc611d
https://pubmed.ncbi.nlm.nih.gov/31271281
https://pubmed.ncbi.nlm.nih.gov/31271281
Autor:
Eric D Leisten, William A. Ricke, Ka Yang, Richard E. Peterson, Gabrielle N. Winston-McPherson, Binkai Liu, Hao Wu, Weiping Tang, Chad M. Vezina
Publikováno v:
Bioorg Med Chem Lett
The Aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor involved in multiple biological processes including immune cell differentiation, intestinal function and inflammation. Based on the scaffold of naturally occurring AhR lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab83e5648274761fc6168e65e1a495f2
https://doi.org/10.1016/j.bmcl.2020.126959
https://doi.org/10.1016/j.bmcl.2020.126959
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
The Journal of reproductive medicine. 17(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2859a94dd1ad47dc6e06f1f41fe22136
https://pubmed.ncbi.nlm.nih.gov/978656
https://pubmed.ncbi.nlm.nih.gov/978656
Publikováno v:
Obstetrics and gynecology. 46(3)
In a continuing oral contraceptive study of d-norgestrel, the 1,0-mg dose--the dose previously found to give the best cycle control--was administered cyclically on a "21-7 day" schedule to 284 women during 2650 cycles. None of the women conceived, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e737517565503c6a46a85dbead05b9ec
https://pubmed.ncbi.nlm.nih.gov/1161234
https://pubmed.ncbi.nlm.nih.gov/1161234