Zobrazeno 1 - 10
of 233
pro vyhledávání: '"D, Lander A"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-43 (2024)
Abstract Background Many approaches have been developed to overcome technical noise in single cell RNA-sequencing (scRNAseq). As researchers dig deeper into data—looking for rare cell types, subtleties of cell states, and details of gene regulatory
Externí odkaz:
https://doaj.org/article/1c805c6f0a6e47c8a01756342320121c
Autor:
Richard D. Lander, Marc J. O’Donnell
Publikováno v:
Clinics in Shoulder and Elbow, Vol 26, Iss 2, Pp 212-216 (2023)
The glenohumeral joint is one of the most commonly dislocated joints. When dislocated, the humeral head typically moves anteriorly and medially within the soft tissues adjacent to the glenoid. We present a case of a 64-year-old female who presented w
Externí odkaz:
https://doaj.org/article/384a5055edb743c983d693fe6612b6ad
Autor:
Jonathan Rodriguez, Abdon Iniguez, Nilamani Jena, Prasanthi Tata, Zhong-Ying Liu, Arthur D Lander, John Lowengrub, Richard A Van Etten
Publikováno v:
eLife, Vol 12 (2023)
Chronic myeloid leukemia (CML) is a blood cancer characterized by dysregulated production of maturing myeloid cells driven by the product of the Philadelphia chromosome, the BCR-ABL1 tyrosine kinase. Tyrosine kinase inhibitors (TKIs) have proved effe
Externí odkaz:
https://doaj.org/article/57621ed8b91f42ae9fcbc9b3d2757ecf
Autor:
Jay Devine, Marta Vidal-García, Wei Liu, Amanda Neves, Lucas D. Lo Vercio, Rebecca M. Green, Heather A. Richbourg, Marta Marchini, Colton M. Unger, Audrey C. Nickle, Bethany Radford, Nathan M. Young, Paula N. Gonzalez, Robert E. Schuler, Alejandro Bugacov, Campbell Rolian, Christopher J. Percival, Trevor Williams, Lee Niswander, Anne L. Calof, Arthur D. Lander, Axel Visel, Frank R. Jirik, James M. Cheverud, Ophir D. Klein, Ramon Y. Birnbaum, Amy E. Merrill, Rebecca R. Ackermann, Daniel Graf, Myriam Hemberger, Wendy Dean, Nils D. Forkert, Stephen A. Murray, Henrik Westerberg, Ralph S. Marcucio, Benedikt Hallgrímsson
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-18 (2022)
Abstract Complex morphological traits are the product of many genes with transient or lasting developmental effects that interact in anatomical context. Mouse models are a key resource for disentangling such effects, because they offer myriad tools f
Externí odkaz:
https://doaj.org/article/7defe75069d24f29bca1c5a94da00059
Autor:
Jay Devine, Marta Vidal-García, Wei Liu, Amanda Neves, Lucas D. Lo Vercio, Rebecca M. Green, Heather A. Richbourg, Marta Marchini, Colton M. Unger, Audrey C. Nickle, Bethany Radford, Nathan M. Young, Paula N. Gonzalez, Robert E. Schuler, Alejandro Bugacov, Campbell Rolian, Christopher J. Percival, Trevor Williams, Lee Niswander, Anne L. Calof, Arthur D. Lander, Axel Visel, Frank R. Jirik, James M. Cheverud, Ophir D. Klein, Ramon Y. Birnbaum, Amy E. Merrill, Rebecca R. Ackermann, Daniel Graf, Myriam Hemberger, Wendy Dean, Nils D. Forkert, Stephen A. Murray, Henrik Westerberg, Ralph S. Marcucio, Benedikt Hallgrímsson
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/be08db417e494e3e9e3dd747d51524cb
Autor:
Jessica Shiu, Arthur D Lander
Publikováno v:
eLife, Vol 10 (2021)
Environmental cues, not oncogene-induced senescence, may stop melanocytes with an activating mutation in the BRAF gene from turning into melanoma.
Externí odkaz:
https://doaj.org/article/e7cd23fc7e7e47a3838d96a666847381
Autor:
Rolando Ruiz-Vega, Chi-Fen Chen, Emaad Razzak, Priya Vasudeva, Tatiana B Krasieva, Jessica Shiu, Michael G Caldwell, Huaming Yan, John Lowengrub, Anand K Ganesan, Arthur D Lander
Publikováno v:
eLife, Vol 9 (2020)
Mutational activation of the BRAF proto-oncogene in melanocytes reliably produces benign nevi (pigmented ‘moles’), yet the same change is the most common driver mutation in melanoma. The reason nevi stop growing, and do not progress to melanoma,
Externí odkaz:
https://doaj.org/article/ebbfba30db8a42e8b8e4e0ad08a82c27
Autor:
Daniel A. Newkirk, Yen-Yun Chen, Richard Chien, Weihua Zeng, Jacob Biesinger, Ebony Flowers, Shimako Kawauchi, Rosaysela Santos, Anne L. Calof, Arthur D. Lander, Xiaohui Xie, Kyoko Yokomori
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-20 (2017)
Abstract Background Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIPBL loads cohesin o
Externí odkaz:
https://doaj.org/article/8a7d88070ff64f7386c9876f9321991a
Autor:
Rebecca M. Green, Lucas D. Lo Vercio, Andreas Dauter, Elizabeth C. Barretto, Jay Devine, Marta Vidal-García, Marta Marchini, Samuel Robertson, Xiang Zhao, Anandita Mahika, M. Bilal Shakir, Sienna Guo, Julia C. Boughner, Wendy Dean, Arthur D. Lander, Ralph S. Marcucio, Nils D. Forkert, Benedikt Hallgrímsson
Morphogenesis requires highly coordinated, complex interactions between cellular processes: proliferation, migration, and apoptosis, along with physical tissue interactions. How these cellular and tissue dynamics drive morphogenesis remains elusive.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::853481149004152883b2952e43a4dcb1
https://doi.org/10.1101/2023.05.12.540515
https://doi.org/10.1101/2023.05.12.540515
Autor:
Abdon Iniguez, Jonathan Rodriguez, Nilamani Jena, Prasanthi Tata, Zhong-Ying Liu, Arthur D Lander, John Lowengrub, Richard A Van Etten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c477dd1f32773365b4e9a922e0dabf59
https://doi.org/10.7554/elife.84149.sa2
https://doi.org/10.7554/elife.84149.sa2