Výsledky vyhledávání

Evidence for multidimensional resilience in adult patients with transfusion-dependent thalassemias: Is it more common than we think?

Autor: S Y, Almahmoud, K G, Coifman, G S, Ross, D, Kleinert, P, Giardina

Publikováno v: Transfusion medicine (Oxford, England). 26(3)

Life expectancy of patients with transfusion-dependent thalassemias has increased with the development of improved treatment over the last few decades. However, β-thalassemia disorder still has considerable lifetime treatment demands and heightened

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81a5b6143c630393021cb81874be036d
https://pubmed.ncbi.nlm.nih.gov/27018402

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Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging

Autor: Michael R. Meiler, Marc Fisher, Turgut Tatlisumak, Richard A.D. Carano, Christopher H. Sotak, Kentaro Takano, H. D. Kleinert

Publikováno v: Scopus-Elsevier

Objective: To explore the utility of intravenous (IV) prourokinase treatment, we compared intra-arterial (IA) and IV delivery in a rat embolic stroke model, using diffusion (DWI) and perfusion (PI) magnetic resonance imaging to assess in vivo effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047b49aef88b8d5272ec73c4de9ee66f
https://doi.org/10.1212/wnl.50.4.870

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Ex vivo inhibition of β-thromboglobulin release following administration to man of ABT-299, a novel prodrug of a potent platelet activating factor antagonist

Autor: H. D. Kleinert, T. J. Magoc, George W. Carter, Douglas W. Morgan, S. D. Menacherry, James B. Summers, E. Sun, A. E. Reyes, Daniel H. Albert

Publikováno v: Inflammation Research. 46:272-277

Objective and Design: ABT-299 is a prodrug that is converted by serum esterase to a potent platelet activating factor (PAF) antagonist (A-85783). In order to evaluate the pharmacological activity of this antagonist in man the effect of ABT-299 given

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab004a283c5d80b5d1a082c6780c5689
https://doi.org/10.1007/s000110050186

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Hemodynamic Effects of Renin Inhibitors

Autor: H D Kleinert

Publikováno v: American Journal of Nephrology. 16:252-260

Renin inhibitors may offer an exciting new therapeutic means of blocking the actions of the renin-angiotensin-aldosterone system. These compounds interfere with the first, rate-limiting step in the synthesis of angiotensin II by binding directly to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a1ace55a4c58adaacec563fc4d92bf
https://doi.org/10.1159/000169005

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Renin inhibition

Autor: H D, Kleinert

Publikováno v: Cardiovascular Drugs and Therapy. 9:645-655

Modification of the renin-angiotensin-aldosterone system by renin inhibitors may be an alternative to angiotensin-converting enzyme inhibitors in the treatment of cardiovascular disease. The development of clinically useful renin inhibitors has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8964b01f61421954be4bf763b387a10e
https://doi.org/10.1007/bf00878547

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Renin inhibitors: C-terminal oxetanes as potent transition-state mimics

Autor: Kenneth P. Spina, Jerome Cohen, Hollis D. Kleinert, William R. Baker, Saul H. Rosenberg, Herman H. Stein

Publikováno v: Bioorganic & Medicinal Chemistry. 2:927-937

A novel transition-state mimic containing a C-tenninal oxetane has been developed. Renin inhibitors incorporating this fragment exhibit enhanced potency against human plasma renin at physiological pH. The binding affinity of this new species has allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0ae31581f25cd569ff4e2f59557443
https://doi.org/10.1016/s0968-0896(00)82042-8

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The significance of a positive DAT in thalassemia patients

Autor: S A, Arinsburg, D L, Skerrett, D, Kleinert, P J, Giardina, M M, Cushing

Publikováno v: Immunohematology. 26(3)

The DAT is performed for the detection of antibody or complement on the surface of RBCs. Our institution previously performed DATs on all chronically transfused thalassemia patients before each transfusion episode to detect early alloimmunization. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::279359bc69062de6158cdffb53982fd9
https://pubmed.ncbi.nlm.nih.gov/21214294

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Effects of Renin Inhibitor A-72517 on Hemodynamics and Cardiac Function in Sodium-Depleted Dogs

Autor: Hollis D. Kleinert, Jerry L Wessale, Samuel V. Calzadilla, Saul H. Rosenberg, Peter Kovar

Publikováno v: American Journal of Hypertension. 6:514-521

A-72517 is a potent inhibitor of human renin (IC50 = 1.0 nmol/L, pH 7.4 in plasma) and, aside from displaying modest activity against canine plasma renin (IC50 = 110 nmol/L), has been shown to be orally active in the dog and other animals. Renin inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75f95e747168460695247e27b005d98
https://doi.org/10.1093/ajh/6.6.514

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