Zobrazeno 1 - 10
of 126
pro vyhledávání: '"D, Kinchington"'
Autor:
D. Kinchington, Harjit Singh, Simon Dunn, Washington Odur Ayuko, Eric Lattmann, Michael J. Tisdale
Publikováno v:
Journal of Pharmacy and Pharmacology. 56:1163-1170
Mucohalogen acids have been used for the preparation of a variety of 3,4-dihalogenated 2(5H)-furanones. In one synthetic step the carbamates 2a-c and the pseudoanhydrides 4a-e were prepared using isocyanates and acid anhydrides. A series of 5-alkoxyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca1150a57c30e1764cdef2f36c85ed9
https://doi.org/10.1211/0022357044201
https://doi.org/10.1211/0022357044201
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:121-130
A number of analogues of benzoic acid were evaluated in a T cell costimulation assay. One compound, the sodium salt of 2-chloro-5-nitrobenzoic acid (CNBA-Na) was chosen for further study and was found to be a potent costimulator of anti-CD3-induced p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6fad1070fe0b69df94cc0d1d0989c13
https://doi.org/10.1177/095632029700800206
https://doi.org/10.1177/095632029700800206
Autor:
D. Kinchington, T. J. O'Connor, R.A.J. Mcllhinney, R. L. Gilbert, David R. Harper, N. Mahmood, D. J. Jeffries
Publikováno v:
Antiviral Chemistry and Chemotherapy. 7:138-141
Following an earlier demonstration of an antiviral effect against varicella-zoster virus (VZV, human herpesvirus 3) using 2-hydroxymyristic acid (2-hydroxytetradecanoic acid; 2-HM), an inhibitor of protein myristoylation, both 2-HM and 2-hydroxypalmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b641d790cd783197f43987f25c4967dc
https://doi.org/10.1177/095632029600700303
https://doi.org/10.1177/095632029600700303
Publikováno v:
International Journal of STD & AIDS. 6:267-272
Summary: The effect of low pH, normally present in the female genital tract, on HIV viability was examined. HIV is more acid stable than previously reported with no substantial reduction in infectivity occurring until pH levels are reduced below 4.5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566938fe18b07ed24de43aa1bbc1baa0
https://doi.org/10.1177/095646249500600409
https://doi.org/10.1177/095646249500600409
Publikováno v:
Antiviral Chemistry and Chemotherapy. 5:162-168
Novel haloalkyl phosphate derivatives of the anti-HIV nucleoside analogue AZT were prepared by phosphorochloridate chemistry. These materials were designed to act as labile membrane-soluble prodrugs of the bio-active free nucleotides. In vitro evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5127fde0452f92106272e830caa45664
https://doi.org/10.1177/095632029400500304
https://doi.org/10.1177/095632029400500304
Autor:
D, Kinchington, E, Berrie
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 5
Two distinct populations of lymphocytes have been identified: T lymphocytes, which are thymus-dependent, and B cells, first observed in the Bursa Fabricus of birds. Mammals do not have an equivalent structure, and there are varying opinions as to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d37db0bf3a546d16873f37a61a8d6df7
https://pubmed.ncbi.nlm.nih.gov/21374113
https://pubmed.ncbi.nlm.nih.gov/21374113
Publikováno v:
Methods in molecular medicine. 24
This chapter describes the procedures that can be used to determine compounds that have antiviral activity against HIV. These include: maintenance of lymphoblastoid cell lines, preparation of peripheral blood mononuclear cells (PMMCs), and determinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbe508b759c94783490e917bf3910a6a
https://pubmed.ncbi.nlm.nih.gov/21331909
https://pubmed.ncbi.nlm.nih.gov/21331909
Publikováno v:
Antiviral Chemistry and Chemotherapy. 4:97-101
Novel phosphoramidate derivatives of the anti-HIV nucleoside analogue AZT have been prepared by phosphorochloridate chemistry. These materials carry carboxy-protected, amino acids, and are designed to act as membrane-soluble prodrugs of the bio-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a6ba94ff2244fea7c86b7d39aac9aa
https://doi.org/10.1177/095632029300400204
https://doi.org/10.1177/095632029300400204
Autor:
K. E. B. Parkes, D. J. Bushnell, S. A. Galpin, I. B. Duncan, Martin Joseph Armstrong, Stephen J. Dunsdon, M. J. Hall, P. J. Machin, NA Roberts, G. J. Thomas, J. H. Merrett, D. Kinchington
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd2d6985f0f67132013c86382eb69e8
https://doi.org/10.1002/chin.199104325
https://doi.org/10.1002/chin.199104325
Autor:
D. Taylor-Robinson, D. Kinchington, B. C. N. M. Jones, J. J. Harvey, D. J. Jeffries, Kevin G. Devine, Christopher McGuigan, T. J. O'Connor
Publikováno v:
Antiviral Chemistry and Chemotherapy. 3:107-112
A number of zidovudine phosphoramidate and phosphorodiamidate derivatives were prepared, including some previously unreported benzyl esterified amino acyl compounds. These were found to be active in vitro against the human immunodeficiency virus (HIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7812de84847a6eca41575ffc730f1c0
https://doi.org/10.1177/095632029200300205
https://doi.org/10.1177/095632029200300205