Zobrazeno 1 - 10
of 458
pro vyhledávání: '"D, Hodgkin"'
Autor:
Dimitra Zotos, Isaak Quast, Connie S. N. Li-Wai-Suen, Craig I. McKenzie, Marcus J. Robinson, Andrey Kan, Gordon K. Smyth, Philip D. Hodgkin, David M. Tarlinton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
How IL-21 functions during development of high affinity antibody in germinal centres (GC) is not fully known. Here using a cell cycle reporter mouse, the authors show that IL-21 promotes cell cycle progression within the GC light zone and enables rel
Externí odkaz:
https://doaj.org/article/bac1ae196b49479fb1cf299b4526a9d7
Autor:
Wing Fuk Chan, Hannah D. Coughlan, Jie H. S. Zhou, Christine R. Keenan, Naiara G. Bediaga, Philip D. Hodgkin, Gordon K. Smyth, Timothy M. Johanson, Rhys S. Allan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide
Externí odkaz:
https://doaj.org/article/7053b41411834244926ee8cb364e2b61
Autor:
HoChan Cheon, Andrey Kan, Giulio Prevedello, Simone C. Oostindie, Simon J. Dovedi, Edwin D. Hawkins, Julia M. Marchingo, Susanne Heinzel, Ken R. Duffy, Philip D. Hodgkin
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2021)
Lymphocytes are the central actors in adaptive immune responses. When challenged with antigen, a small number of B and T cells have a cognate receptor capable of recognising and responding to the insult. These cells proliferate, building an exponenti
Externí odkaz:
https://doaj.org/article/584926d25cf74cb9a5207f1222d8115c
Autor:
Isabella Y. Kong, Joel S. Rimes, Amanda Light, Izabela Todorovski, Sarah Jones, Eric Morand, Deborah A. Knight, Ylva E. Bergman, Simon J. Hogg, Hendrik Falk, Brendon J. Monahan, Paul A. Stupple, Ian P. Street, Susanne Heinzel, Philippe Bouillet, Ricky W. Johnstone, Philip D. Hodgkin, Stephin J. Vervoort, Edwin D. Hawkins
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108290- (2020)
Summary: JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces
Externí odkaz:
https://doaj.org/article/ee968f52f07046a6b68bf519b3e86ce7
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2557-2566 (2018)
Summary: A thorough understanding of cellular development is incumbent on assessing the complexities of fate and kinetics of individual clones within a population. Here, we develop a system for robust periodical assessment of lineage outputs of thous
Externí odkaz:
https://doaj.org/article/f0539743add347688cf8dfedc695462d
Autor:
Marcus James Robinson, Zhoujie Ding, Mark R. Dowling, Danika L. Hill, Rosela H. Webster, Craig McKenzie, Catherine Pitt, Kristy O’Donnell, Jesse Mulder, Erica Brodie, Philip D. Hodgkin, Nick C. Wong, Isaak Quast, David M. Tarlinton
Publikováno v:
Immunity.
Autor:
Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F. Pascutti, Anna E. Oja, Alexandra L. Garnham, Renee Gloury, Jessica C. Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W. Kuijpers, Najoua Lalaoui, Lisa A. Mielke, Vanessa L. Bryant, Philip D. Hodgkin, John Silke, Gordon K. Smyth, Martijn A. Nolte, Wei Shi, Axel Kallies
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2906-2920 (2017)
After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully suppressive effector (e)Treg cells in a process dependent on TCR signaling and the transcription
Externí odkaz:
https://doaj.org/article/a6158e2926c7412c92b606577bc61e39
Autor:
Robyn M. Sutherland, Sarah L. Londrigan, Jamie L. Brady, Emma M. Carrington, Julia M. Marchingo, Susanne Heinzel, Philip D. Hodgkin, Kate L. Graham, Thomas W. Kay, Yifan Zhan, Andrew M. Lew
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Professional antigen presenting cells (APC) are the major activator of T cells that then hone to sites of inflammation. Using islet cell grafts, here the authors show that parenchymal cells can present antigen to activate CD8+T cells at inflammatory
Externí odkaz:
https://doaj.org/article/ddf258470896415aaf2e07fd3e6bba40
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Why do populations of highly similar T cells have heterogeneous division destinies in response to antigenic stimulus? Here the authors develop a multiplex-dye assay and a mathematical framework to test clonal heterogeneity and show distinction in div
Externí odkaz:
https://doaj.org/article/95b6391d198249d286ba54ffd85a581c
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