Zobrazeno 1 - 10
of 1 472
pro vyhledávání: '"D, Haase"'
Autor:
Parthena Konstantinidou, Zuzana Loubalova, Franziska Ahrend, Aleksandr Friman, Miguel Vasconcelos Almeida, Axel Poulet, Filip Horvat, Yuejun Wang, Wolfgang Losert, Hernan Lorenzi, Petr Svoboda, Eric A. Miska, Josien C. van Wolfswinkel, Astrid D. Haase
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114777- (2024)
Summary: PIWI-interacting RNAs (piRNAs) play a crucial role in safeguarding genome integrity by silencing mobile genetic elements. From flies to humans, piRNAs originate from long single-stranded precursors encoded by genomic piRNA clusters. How piRN
Externí odkaz:
https://doaj.org/article/d5ee216aeb984bc49d474c711d1860ea
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract PIWI-interacting RNAs (piRNAs) are responsible for preventing the movement of transposable elements in germ cells and protect the integrity of germline genomes. In this review, we examine the common elements of piRNA-guided silencing as well
Externí odkaz:
https://doaj.org/article/d3a8e7c26a3d4956bc68bc19ea34b67e
Autor:
Astrid D. Haase
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 1094-1102 (2022)
PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) constitute a small RNA-based adaptive immune system that restricts the deleterious activity of mobile genetic elements to protect genome integrity. Self/nonself discrimination is at th
Externí odkaz:
https://doaj.org/article/960d41110cb7402ba7ff007f6d6bd620
Publikováno v:
Natural Hazards and Earth System Sciences, Vol 21, Pp 203-217 (2021)
The most common approach to assessing natural hazard risk is investigating the willingness to pay in the presence or absence of such risk. In this work, we propose a new, machine-learning-based, indirect approach to the problem, i.e. through resident
Externí odkaz:
https://doaj.org/article/5bad9fa92a3847db9eac640cefa6332f
Autor:
N. Kabisch, R. Kraemer, M. E. Brenck, D. Haase, A. Lausch, M. L. Luttkus, T. Mueller, P. Remmler, P. von Döhren, J. Voigtländer, J. Bumberger
Publikováno v:
Ecosystems and People, Vol 17, Iss 1, Pp 464-475 (2021)
Climate change, urbanisation and demographic change affect urban areas and pose a range of health-related challenges to urban residents, including heat waves, drought periods, air pollution and densification processes. Urban green spaces provide ecos
Externí odkaz:
https://doaj.org/article/d7af8571053042fb82893992280d9916
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104427- (2022)
Summary: PIWI-interacting RNAs (piRNAs) guard germline genomes against the deleterious action of mobile genetic elements. PiRNAs use extensive base-pairing to recognize their targets and variable 3′ends could change the specificity and efficacy of
Externí odkaz:
https://doaj.org/article/eaa70149f3de4390b34ae61fbb470c0e
Autor:
Larissa Fabritz, D. Connolly, E. Czarnecki, D. Dudek, A. Zlahoda-Huzior, E. Guasch, D. Haase, T. Huebner, K. Jolly, P. Kirchhof, Ulrich Schotten, Antonia Zapf, Renate B. Schnabel
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
IntroductionScreening for atrial fibrillation and timely initiation of oral anticoagulation, rhythm management, and treatment of concomitant cardiovascular conditions can improve outcomes in high-risk populations. Whether wearables can facilitate scr
Externí odkaz:
https://doaj.org/article/d6226fd782a44283b453b30a8a4c8dc5
Autor:
Florencia D. Haase, Bronte Coorey, Lisa Riley, Laurence C. Cantrill, Patrick P. L. Tam, Wendy A. Gold
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder, mostly caused by mutations in MECP2. The disorder mainly affects girls and it is associated with severe cognitive and physical disabilities. Modeling RTT in neural and glial cell culture
Externí odkaz:
https://doaj.org/article/06e4d5b016054a928b140c8c81135b09
Autor:
Chad B. Stein, Pavol Genzor, Sanga Mitra, Alexandra R. Elchert, Jonathan J. Ipsaro, Leif Benner, Sushil Sobti, Yijun Su, Molly Hammell, Leemor Joshua-Tor, Astrid D. Haase
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
PIWI-interacting RNAs (piRNAs) are regulatory RNAs that bind to PIWI proteins to control transposons and maintain genome integrity. Here the authors characterized their binding specificity and reveal the 5′ nucleotide bias of the Drosophila Piwi pr
Externí odkaz:
https://doaj.org/article/58d34676a5714e7abafef2822ed72676
Publikováno v:
eLife, Vol 9 (2020)
Key to CRISPR-Cas adaptive immunity is maintaining an ongoing record of invading nucleic acids, a process carried out by the Cas1-Cas2 complex that integrates short segments of foreign genetic material (spacers) into the CRISPR locus. It is hypothesi
Externí odkaz:
https://doaj.org/article/41ac509c24284d8ba48eeb0c2864f484