Zobrazeno 1 - 10
of 58
pro vyhledávání: '"D, Gunasinghe"'
Autor:
Catarina F. Almeida, Benjamin S. Gully, Claerwen M. Jones, Lukasz Kedzierski, Sachith D. Gunasinghe, Michael T. Rice, Richard Berry, Nicholas A. Gherardin, Trang T. Nguyen, Yee-Foong Mok, Josephine F. Reijneveld, D. Branch Moody, Ildiko Van Rhijn, Nicole L. La Gruta, Adam P. Uldrich, Jamie Rossjohn, Dale I. Godfrey
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract αβ T cell receptors (αβTCRs) co-recognise antigens when bound to Major Histocompatibility Complex (MHC) or MHC class I-like molecules. Additionally, some αβTCRs can bind non-MHC molecules, but how much intact antigen reactivities are a
Externí odkaz:
https://doaj.org/article/a4fb52352ddb44ba9d2176f3352758f0
Autor:
D. Ranasinghe, C. Jeewandara, T. Jayadas, D. Jayathilaka, D. Gunasinghe, F. Bary, R. Perera, H. Kuruppu, D. Ariyaratne, G. Ogg, G. Malavige
Publikováno v:
International Journal of Infectious Diseases, Vol 134, Iss , Pp S11-S12 (2023)
Intro: Sri Lanka detected the first infection due to BA.1 back in November 2021, which was quickly replaced by BA.2 by end of January. With detection of BA.5.2 in late June 2022, the number of symptomatic cases has increased without a similar increas
Externí odkaz:
https://doaj.org/article/d09959f20e214cbda7dd204ce98f0d73
Autor:
Marcin Wegrecki, Tonatiuh A. Ocampo, Sachith D. Gunasinghe, Anouk von Borstel, Shin Yi Tin, Josephine F. Reijneveld, Thinh-Phat Cao, Benjamin S. Gully, Jérôme Le Nours, D. Branch Moody, Ildiko Van Rhijn, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
T cell receptors are generally thought to contact antigens presented in an end to end configuration. Here the authors show a geometrically alternate sideways mode of recognition of the antigen-presenting molecule CD1a by a γδ T cell receptor.
Externí odkaz:
https://doaj.org/article/a5eb21242f424541a6a488c362e95bcb
Autor:
T.T. Pramanayagam Jayadas, C. Jeewandara, D. Jayathilaka, D. Ranasinghe, D. Ariyarathne, A. Wijesinghe, D. Gunasinghe, L. Gomes, D. Madushanka, O. Dissanayake, M. Harvie, F. Bary, N. Malavige
Publikováno v:
International Journal of Infectious Diseases, Vol 116, Iss , Pp S34- (2022)
Purpose: Surveillance of different SARS-CoV-2 variants of concern (VOCs) is a crucial aspect in control of the pandemic. Although sequencing is the gold-standard to detect VOCs, it is labor intensive and is costly. We compared a cost-effective real-t
Externí odkaz:
https://doaj.org/article/52109d8230fb413989c03e8f99c143b8
Autor:
Rhys Grinter, Faye C. Morris, Rhys A. Dunstan, Pok Man Leung, Ashleigh Kropp, Matthew Belousoff, Sachith D. Gunasinghe, Nichollas E. Scott, Simone Beckham, Anton Y. Peleg, Chris Greening, Jian Li, Eva Heinz, Trevor Lithgow
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Acinetobacter baumannii is a high-risk pathogen due to the rapid global spread of multidrug-resistant lineages. Its phylogenetic divergence from other ESKAPE pathogens means that determinants of its antimicrobial resistance can be difficult
Externí odkaz:
https://doaj.org/article/1c28d5a874e247828497d0aa8a7f21e3
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Understanding the mechanisms behind T cell dysfunctions during chronic diseases is critical in developing effective immunotherapies. As demonstrated by several animal models and human studies, T cell dysfunctions are induced during chronic diseases,
Externí odkaz:
https://doaj.org/article/115f99d7f0784a168a3b1166d25eb3d8
Autor:
Sachith D. Gunasinghe, Takuya Shiota, Christopher J. Stubenrauch, Keith E. Schulze, Chaille T. Webb, Alex J. Fulcher, Rhys A. Dunstan, Iain D. Hay, Thomas Naderer, Donna R. Whelan, Toby D.M. Bell, Kirstin D. Elgass, Richard A. Strugnell, Trevor Lithgow
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2782-2794 (2018)
The β-barrel assembly machinery (BAM) complex is essential for localization of surface proteins on bacterial cells, but the mechanism by which it functions is unclear. We developed a direct stochastic optical reconstruction microscopy (dSTORM) metho
Externí odkaz:
https://doaj.org/article/4887ae9993cc45509e28c04949566915
Autor:
H. J. Hugo, N. P. A. D. Gunasinghe, B. G. Hollier, T. Tanaka, T. Blick, A. Toh, P. Hill, C. Gilles, M. Waltham, E. W. Thompson
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-25 (2017)
Abstract Background Epithelial-to-mesenchymal transition (EMT) is associated with downregulated E-cadherin and frequently with decreased proliferation. Proliferation may be restored in secondary metastases by mesenchymal-to-epithelial transition (MET
Externí odkaz:
https://doaj.org/article/cc4b2c2fc91d44ceb13aa21c9a041e48
Super-Resolution Imaging of Protein Secretion Systems and the Cell Surface of Gram-Negative Bacteria
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Gram-negative bacteria have a highly evolved cell wall with two membranes composed of complex arrays of integral and peripheral proteins, as well as phospholipids and glycolipids. In order to sense changes in, respond to, and exploit their environmen
Externí odkaz:
https://doaj.org/article/d43c2560c9fd47e1b7b1a6afc03e4506
Autor:
Daniel J. Nieves, Elvis Pandzic, Sachith D. Gunasinghe, Jesse Goyette, Dylan M. Owen, J. Justin Gooding, Katharina Gaus
Publikováno v:
Nanoscale. 14(9)
T cells are highly sensitive to low levels of antigen, but how this sensitivity is achieved is currently unknown. Here, we imaged proximal TCR-CD3 signal propagation with single molecule localization microscopy (SMLM) in T cells activated with nanosc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0a9d9818357a7657956445fc151fe5
https://pubmed.ncbi.nlm.nih.gov/35171177
https://pubmed.ncbi.nlm.nih.gov/35171177