Zobrazeno 1 - 10
of 360
pro vyhledávání: '"D, Grahame Hardie"'
Autor:
Daniel M. Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J. Park, Victoria L. Hewitt, David Zhang, Kevin C. Gonzalez, Fiona M. Russell, D. Grahame Hardie, Julien Prudent, Erik Bloss, Attila Losonczy, Franck Polleux, Tommy L. Lewis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles in synaptic function and neuronal response properties. Mitochondrial morphology differs significantly between the a
Externí odkaz:
https://doaj.org/article/4622b875797a4a148a830a6b459942d0
Autor:
Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Unlike AMPK, Liver kinase B1 (LBK1) is required for carotid body chemosensing and the hypoxic ventilatory response. Moreover, loss of LBK1, but not AMPK, provokes Cheyne-Stokes-like breathing during hypoxia, which is associated with heart failure.
Externí odkaz:
https://doaj.org/article/b2f40950c892468d9001b1c437412b1e
Autor:
Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110761- (2022)
Summary: AMP-activated protein kinase (AMPK) coordinates energy homeostasis during metabolic and energy stress. We report that the catalytic subunit isoform AMPK-α1 (but not α2) is cleaved by caspase-3 at an early stage during induction of apoptosi
Externí odkaz:
https://doaj.org/article/dc89a458593d474787f73e8f3cb61c58
Autor:
Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/13d010bbbbb043198eb9f05b25e647fe
Publikováno v:
Open Biology, Vol 9, Iss 7 (2019)
The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched on by increases in cellular AMP : ATP ratios, it acts to restore energy homeostasis by switching on catabolic pathways while switching off cell growth and prolife
Externí odkaz:
https://doaj.org/article/80c9c9190be44145b1fbeda335455d0c
Autor:
Diana Vara-Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, Abdelmadjid Atrih, Marc Foretz, Benoit Viollet, Douglas J. Lamont, Doreen A. Cantrell, D. Grahame Hardie
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 690-698.e4 (2019)
Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk.
Externí odkaz:
https://doaj.org/article/db8d81d633214b928b39b3ad83b03e1d
Autor:
D. Grahame Hardie, A. Mark Evans, Ejaife O. Egbani, Alexander Gray, Madhumita Dandapani, Diana Vara-Ciruelos
Many genotoxic cancer treatments activate AMP-activated protein kinase (AMPK), but the mechanisms of AMPK activation in response to DNA damage, and its downstream consequences, have been unclear. In this study, etoposide activates the α1 but not the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ac6dbdb1f022cabfc5c5d3274ad6b4
https://doi.org/10.1158/1541-7786.c.6540435.v1
https://doi.org/10.1158/1541-7786.c.6540435.v1
Autor:
D. Grahame Hardie, Graeme J. Gowans, Alexander Gray, Diana Vara Ciruelos, Fiona A. Ross, Sarah Fogarty
The AMP-activated protein kinase (AMPK) is activated by phosphorylation at Thr172, either by the tumor suppressor kinase LKB1 or by an alternate pathway involving the Ca2+/calmodulin-dependent kinase, CAMKK2. Increases in AMP:ATP and ADP:ATP ratios,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b57d6fa029e3ecaeee2012b9207f6e5
https://doi.org/10.1158/1541-7786.c.6539973.v1
https://doi.org/10.1158/1541-7786.c.6539973.v1
Autor:
D. Grahame Hardie, Graeme J. Gowans, Alexander Gray, Diana Vara Ciruelos, Fiona A. Ross, Sarah Fogarty
Cellular stresses that increase AMP:ATP and AMP:ATP ratios activate AMPK in normal cells by promoting its phosphorylation by LKB1. This triggers inhibition of cell growth by phosphorylation of acetyl-CoA carboxylase (ACC), Raptor and other targets, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7f096a646d6fa9fa5b00f7f6db98c1
https://doi.org/10.1158/1541-7786.22511550
https://doi.org/10.1158/1541-7786.22511550
Autor:
D. Grahame Hardie, A. Mark Evans, Ejaife O. Egbani, Alexander Gray, Madhumita Dandapani, Diana Vara-Ciruelos
Supplementary Figure S1: Etoposide activates AMPK in the nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90dda041246fe295ccbdc24f09a8af1
https://doi.org/10.1158/1541-7786.22513104.v1
https://doi.org/10.1158/1541-7786.22513104.v1