Zobrazeno 1 - 10
of 1 722
pro vyhledávání: '"D, Goldin"'
Autor:
Imanol Duran, Joaquim Pombo, Bin Sun, Suchira Gallage, Hiromi Kudo, Domhnall McHugh, Laura Bousset, Jose Efren Barragan Avila, Roberta Forlano, Pinelopi Manousou, Mathias Heikenwalder, Dominic J. Withers, Santiago Vernia, Robert D. Goldin, Jesús Gil
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Cellular senescence is a stress response with broad pathophysiological implications. Senotherapies can induce senescence to treat cancer or eliminate senescent cells to ameliorate ageing and age-related pathologies. However, the success of s
Externí odkaz:
https://doaj.org/article/5c897b7121a9453294556dca1837ca68
Autor:
Charlotte Hateley, Antoni Olona, Laura Halliday, Matthew L. Edin, Jeong-Hun Ko, Roberta Forlano, Ximena Terra, Fred B. Lih, Raúl Beltrán-Debón, Penelopi Manousou, Sanjay Purkayastha, Krishna Moorthy, Mark R. Thursz, Guodong Zhang, Robert D. Goldin, Darryl C. Zeldin, Enrico Petretto, Jacques Behmoaras
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105127- (2024)
Summary: Background: Obesity drives maladaptive changes in the white adipose tissue (WAT) which can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated liver disease (MASLD). Obesity-mediated l
Externí odkaz:
https://doaj.org/article/f522db65b00f4ac6b5690aad31edc432
Autor:
Nick Powell, Mark R Thursz, Kevin J Woollard, James Larkin, Samra Turajlic, Stephen R Atkinson, Robert D Goldin, Evangelos Triantafyllou, Lucia A Possamai, Charalambos G Antoniades, Cathrin L C Gudd, Eoin Mitchell, Marie-Anne Mawhin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Checkpoint inhibitor-induced hepatitis (CPI-hepatitis) is an emerging problem with the widening use of CPIs in cancer immunotherapy. Here, we developed a mouse model to characterize the mechanism of CPI-hepatitis and to therapeutically tar
Externí odkaz:
https://doaj.org/article/ef7d49df3e824b6ba015b5adda0e950e
Autor:
Elliot H. Akama-Garren, Paul Miller, Thomas M. Carroll, Michael Tellier, Gopinath Sutendra, Ludovico Buti, Justyna Zaborowska, Robert D. Goldin, Elizabeth Slee, Francis G. Szele, Shona Murphy, Xin Lu
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-16 (2023)
Abstract Maintenance of immunological homeostasis between tolerance and autoimmunity is essential for the prevention of human diseases ranging from autoimmune disease to cancer. Accumulating evidence suggests that p53 can mitigate phagocytosis-induce
Externí odkaz:
https://doaj.org/article/7ddb2a87a50c4c5aa87bfd63438d5eb9
Integrated phenotyping of the anti-cancer immune response in HIV-associated hepatocellular carcinoma
Autor:
David J. Pinato, Takahiro Kaneko, Antonio D’Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Díaz, Francesco A. Mauri, Claudia A.M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose María Miró, Mark Bower, Norbert Bräu, Vincenzo Mazzaferro
Publikováno v:
JHEP Reports, Vol 5, Iss 7, Pp 100741- (2023)
Background & Aims: HIV-seropositivity shortens survival in patients with hepatocellular carcinoma (HCC). Although risk factors for HCC including HCV infection can influence T cell phenotype, it is unknown whether HIV can influence functional characte
Externí odkaz:
https://doaj.org/article/28357346c44e48efaa343ba7b862ee46
Autor:
Nila Jambulingam, Roberta Forlano, Benjamin Preston, Benjamin H. Mullish, Greta Portone, Yama Baheer, Michael Yee, Robert D. Goldin, Mark R. Thursz, Pinelopi Manousou
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3563 (2023)
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide, with fibrosis stage being the main predictor for clinical outcomes. Here, we present the metabolic profile of NAFLD patients with regards to fibrosis prog
Externí odkaz:
https://doaj.org/article/9f46d9c05799466486a87c71bac4156a
Autor:
Parvin Begum, MBChB.(Hons), Robert D. Goldin, MD, Lucia A. Possamai, PhD, Sanjay Popat, FRCP, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 9, Pp 100213- (2021)
Sotorasib is a first-in-class small molecule that irreversibly inhibits KRAS G12C, locking it in an inactive state, inhibiting oncogenic signaling, and inducing a proinflammatory microenvironment. Here, we report the first case of life-threatening he
Externí odkaz:
https://doaj.org/article/d35246bc42e64d37a88a15bf7ca7fe13
Autor:
Vincenzo Mazzaferro, Federica Grillo, Pierluigi Toniutto, Petros Fessas, Francesco A Mauri, Teresa Marafioti, Ayse U Akarca, Alejandro Forner, Robert D Goldin, Alba Díaz, David J. Pinato, Sam M Murray, Takahiro Kaneko, Beatriz Mínguez, Valentina Cacciato, Claudio Avellini, Rosemary J. Boyton, Daniel M. Altmann, Edoardo Casagrande, Edoardo Giannini, Sherrie Bhoori
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/a973066887174810bc7aff81b2ac8b76
Autor:
Alexandros Arjmand, Odysseas Tsakai, Vasileios Christou, Alexandros T. Tzallas, Markos G. Tsipouras, Roberta Forlano, Pinelopi Manousou, Robert D. Goldin, Christos Gogos, Evripidis Glavas, Nikolaos Giannakeas
Publikováno v:
Information, Vol 13, Iss 4, p 160 (2022)
Non-alcoholic fatty pancreas disease (NAFPD) is a common and at the same time not extensively examined pathological condition that is significantly associated with obesity, metabolic syndrome, and insulin resistance. These factors can lead to the dev
Externí odkaz:
https://doaj.org/article/18fef1fc4b4e45a18cde2eb84a2ac301
Autor:
Ameet Dhar, Fouzia Sadiq, Quentin M. Anstee, Adam P. Levene, Robert D. Goldin, Mark R. Thursz
Publikováno v:
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells a
Externí odkaz:
https://doaj.org/article/640bcbf0d43143d0943fc531e25371e9