INhaled Sedation versus Propofol in REspiratory failure in the Intensive Care Unit (INSPiRE-ICU1): protocol for a randomised, controlled trial

Autor: Craig S Jabaley, John W Devlin, Steven H Hsu, Timothy D Girard, Hina Faisal, Christina Boncyk, Ida Sverud, Magnus Falkenhav, John Kress, Karen Sheppard, Peter V Sackey, Christopher G Hughes

Publikováno v: BMJ Open, Vol 14, Iss 10 (2024)

Introduction Sedation in mechanically ventilated adults in the intensive care unit (ICU) is commonly achieved with intravenous infusions of propofol, dexmedetomidine or benzodiazepines. Significant limitations associated with each can impact their us

Externí odkaz: https://doaj.org/article/429782ef04ec428e9b25a96effd806a2

Association between cholinesterase activity and critical illness brain dysfunction

Autor: Christopher G. Hughes, Christina S. Boncyk, Benjamin Fedeles, Pratik P. Pandharipande, Wencong Chen, Mayur B. Patel, Nathan E. Brummel, James C. Jackson, Rameela Raman, E. Wesley Ely, Timothy D. Girard

Publikováno v: Critical Care, Vol 26, Iss 1, Pp 1-12 (2022)

Abstract Background Delirium is a frequent manifestation of acute brain dysfunction and is associated with cognitive impairment. The hypothesized mechanism of brain dysfunction during critical illness is centered on neuroinflammation, regulated in pa

Externí odkaz: https://doaj.org/article/cb57e9307eaa44bbb76a07a485c327af

Chronic neuropsychiatric sequelae of SARS‐CoV‐2: Protocol and methods from the Alzheimer's Association Global Consortium

Autor: Gabriel A. deErausquin, Heather Snyder, Traolach S. Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, Carmela Tartaglia, Charlotte Teunissen, Krister Håkanson, Rufus Akinyemi, Kameshwar Prasad, Giovanni D'Avossa, Gabriela Gonzalez‐Aleman, Akram Hosseini, George D. Vavougios, Perminder Sachdev, John Bankart, Niels Peter Ole Mors, Richard Lipton, Mindy Katz, Peter T. Fox, Mohammad Zia Katshu, M. Sriram Iyengar, Galit Weinstein, Hamid R. Sohrabi, Rachel Jenkins, Dan J. Stein, Jacques Hugon, Venetsanos Mavreas, John Blangero, Carlos Cruchaga, Murali Krishna, Ovais Wadoo, Rodrigo Becerra, Igor Zwir, William T. Longstreth, Golo Kroenenberg, Paul Edison, Elizabeta Mukaetova‐Ladinska, Ekkehart Staufenberg, Mariana Figueredo‐Aguiar, Agustín Yécora, Fabiana Vaca, Hernan P. Zamponi, Vincenzina Lo Re, Abdul Majid, Jonas Sundarakumar, Hector M. Gonzalez, Mirjam I. Geerlings, Ingmar Skoog, Alberto Salmoiraghi, Filippo Martinelli Boneschi, Vibuthi N. Patel, Juan M. Santos, Guillermo Rivera Arroyo, Antonio Caballero Moreno, Pascal Felix, Carla Gallo, Hidenori Arai, Masahito Yamada, Takeshi Iwatsubo, Malveeka Sharma, Nandini Chakraborty, Catterina Ferreccio, Dickens Akena, Carol Brayne, Gladys Maestre, Sarah Williams Blangero, Luis I. Brusco, Prabha Siddarth, Timothy M. Hughes, Alfredo Ramírez Zuñiga, Joseph Kambeitz, Agustin Ruiz Laza, Norrina Allen, Stella Panos, David Merrill, Agustín Ibáñez, Debby Tsuang, Nino Valishvili, Srishti Shrestha, Sophia Wang, Vasantha Padma, Kaarin J. Anstey, Vijayalakshmi Ravindrdanath, Kaj Blennow, Paul Mullins, Emilia Łojek, Anand Pria, Thomas H. Mosley, Penny Gowland, Timothy D. Girard, Richard Bowtell, Farhaan S. Vahidy

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)

Abstract Introduction Coronavirus disease 2019 (COVID‐19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID‐19 includes c

Externí odkaz: https://doaj.org/article/d13505bb74fe40b480f73735fd3712ef

Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement

Autor: Melissa P. Knauert, Najib T. Ayas, Karen J. Bosma, Xavier Drouot, Mojdeh S. Heavner, Robert L. Owens, Paula L. Watson, M. Elizabeth Wilcox, Brian J. Anderson, Makayla L. Cordoza, John W. Devlin, Rosalind Elliott, Brian K. Gehlbach, Timothy D. Girard, Biren B. Kamdar, Amy S. Korwin, Elizabeth R. Lusczek, Sairam Parthasarathy, Claudia Spies, Jag Sunderram, Irene Telias, Gerald L. Weinhouse, Phyllis C. Zee

Publikováno v: American journal of respiratory and critical care medicine, vol 207, iss 7

Background: Sleep and circadian disruption (SCD) is common and severe in the ICU. On the basis of rigorous evidence in non-ICU populations and emerging evidence in ICU populations, SCD is likely to have a profound negative impact on patient outcomes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22c0ced6f69d919d19c8c8bb1eb9eeb
https://doi.org/10.1164/rccm.202301-0184st

Strategies to Promote ResiliencY (SPRY): a randomised embedded multifactorial adaptative platform (REMAP) clinical trial protocol to study interventions to improve recovery after surgery in high-risk patients

Autor: Derek C Angus, Jennifer Holder-Murray, Katherine Moll Reitz, Christopher W Seymour, Jennifer Vates, Melanie Quintana, Kert Viele, Michelle Detry, Michael Morowitz, Alison Morris, Barbara Methe, Jason Kennedy, Brian Zuckerbraun, Timothy D Girard, Oscar C Marroquin, Stephen Esper, Anne B Newman, Scott Berry, Matthew Neal

Publikováno v: BMJ Open, Vol 10, Iss 9 (2020)

Introduction As the population ages, there is interest in strategies to promote resiliency, especially for frail patients at risk of its complications. The physiological stress of surgery in high-risk individuals has been proposed both as an importan

Externí odkaz: https://doaj.org/article/b9c524c0611f41caaeb63d568cb8ea1b