Zobrazeno 1 - 10
of 32
pro vyhledávání: '"D, Frein"'
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 3, p 648 (2017)
The synthesis of two deoxygenated analogues of potent epothilones is reported in an effort to analyze the relative importance of molecular conformation and ligand–target interactions to biological activity. 7-deoxy-epothilone D and 7-deoxy-(S)-14-m
Externí odkaz:
https://doaj.org/article/aa67d7c18db548f1b090847f67db0e5e
Publikováno v:
International Journal of Molecular Sciences; Volume 18; Issue 3; Pages: 648
International Journal of Molecular Sciences, Vol 18, Iss 3, p 648 (2017)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 3, p 648 (2017)
International Journal of Molecular Sciences
The synthesis of two deoxygenated analogues of potent epothilones is reported in an effort to analyze the relative importance of molecular conformation and ligand–target interactions to biological activity. 7-deoxy-epothilone D and 7-deoxy-(S)-14-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc372e24cfab201939a7648f89ae1963
Publikováno v:
Organic Letters. 9:5099-5102
A highly diastereoselective intermolecular Heck reaction of 1,3-dioxepins is reported. Substitution at both the 2- and 4-positions of the dioxepin directs the Pd coordination and subsequent olefin insertion to provide the trans-disubstituted adduct i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6122bfdaf12e30fc744280a77ef1ddfd
https://doi.org/10.1021/ol702294u
https://doi.org/10.1021/ol702294u
Autor:
Agnès Sallé, Maxime Gerard, Claire Briet, Régis Coutant, Stéphanie Rouleau, Loïc Sentilhes, Géraldine Gascoin, Françoise Schmitt, Guillaume Becouarn, Philippe Topart, D. Frein
Publikováno v:
Annales d'Endocrinologie. 76:297-298
Background Maternal bariatric surgery is associated with an increased risk of small-for-gestational-age infants. The risk of nutritional deficiencies in neonates of mothers with prior gastric bypass (GBP) is unclear. Methods This study compared the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a2ec7992bd3640ade0d535fcee1dce
https://doi.org/10.1016/j.ando.2015.07.026
https://doi.org/10.1016/j.ando.2015.07.026
Publikováno v:
Organic letters. 11(15)
A concise total synthesis of (S)-14-methoxyepothilone D has been accomplished. (S)-14-Methoxyepothilone D represents a conceptually novel example of polyketide analogue design based on an alternative biogenetic pattern of extender units. The signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946d528f93cc9561d7af8d50622ce2e6
https://pubmed.ncbi.nlm.nih.gov/19572566
https://pubmed.ncbi.nlm.nih.gov/19572566
Publikováno v:
The Journal of organic chemistry. 73(14)
Stereoselective synthesis of trans-2,6-disubstituted-3,4-dihydropyrans has been achieved from a simple homoallylic alkoxyether via a three-step sequence: electrophile-induced ether transfer, cyclization, and functionalization, which is highlighted by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3494fd660289527f2140594e823b6b56
https://pubmed.ncbi.nlm.nih.gov/18570473
https://pubmed.ncbi.nlm.nih.gov/18570473
Publikováno v:
La Revue de medecine interne. 28(10)
Hypercalcaemia occurs in less than 15% of lymphomas but is associated with a poor prognosis. A patient known to have a testicular lymphoma was admitted because of asthenia and weight loss. Hypercalcemia and high serum level of calcitriol were found.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c31f2fe58c57feda8ef05a3615e9c185
https://pubmed.ncbi.nlm.nih.gov/17544176
https://pubmed.ncbi.nlm.nih.gov/17544176
Autor:
Tomislav Rovis, Jeffrey D. Frein
We have examined several methods for the stereoselective formation of carbon-carbon bonds between contiguous rings where a stereogenic center is already present. The approaches investigated were a [1,3] oxygen to carbon rearrangement of cyclic vinyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cb185509038387280718d2b5bf982f
https://europepmc.org/articles/PMC1950123/
https://europepmc.org/articles/PMC1950123/
Autor:
S. Laboureau, Philippe Menei, D. Frein, Frédéric Illouz, P. Abgueguen, M. Lebeault, Patrice Rodien
Publikováno v:
Annales d'Endocrinologie. 75:422
Nous rapportons un cas d’abces hypophysaire recidivant. Cas Clinique Une patiente de 60 ans presente brutalement des cephalees, une baisse de l’acuite visuelle et une hemianopsie bitemporale. Il n’y a pas de fievre. L’IRM montre une masse hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd355adab028ddbb80457a86fcf62e5
https://doi.org/10.1016/j.ando.2014.07.508
https://doi.org/10.1016/j.ando.2014.07.508
Publikováno v:
La Revue de Médecine Interne. 28:714-715
Resume Une hypercalcemie est observee dans moins de 15 % des lymphomes mais son apparition est un facteur de mauvais pronostic. Nous rapportons l'observation d'un patient aux antecedents de lymphome testiculaire hospitalise pour une alteration de l'e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daa66916195fc3c5fc33a66933aeb49c
https://doi.org/10.1016/j.revmed.2007.05.002
https://doi.org/10.1016/j.revmed.2007.05.002