Zobrazeno 1 - 10
of 79
pro vyhledávání: '"D, Fraier"'
Akademický článek
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Autor:
Jim Cassidy, Chris Twelves, Donald Bissett, M Main, M G Porro, M L Magnè, L Robson, W Speed, J.S. de Bono, C Pellizzoni, D Fraier, F Muirhead, R Spinelli
Publikováno v:
British Journal of Cancer
Polymeric cytotoxic conjugates are being developed with the aim of preferential delivery of the anticancer agent to tumour. MAG-CPT comprises the topoisomerase I inhibitor camptothecin linked to a water-soluble polymeric backbone methacryloylglycynam
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 30:377-389
A selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS-MS) method for quantitative determination of nemorubicin, (PNU-152243A, 3'-deamino-3'[2(S)-methoxy-4-morpholinyl]doxorubicin) hydrocloride and its reduced metabolite PNU-
Autor:
Nadja E. Schoemaker, Sindy Jansen, Jan Lieverst, R Spinelli, Massimo Breda, M. Swart, C Pellizzoni, Hilde Rosing, C. van Kesteren, D Fraier, M Grazia Porro, W.W. ten Bokkel Huinink, Jos H. Beijnen, Jan H.M. Schellens
Publikováno v:
British Journal of Cancer
Polymeric drug conjugates are a new and experimental class of drug delivery systems with pharmacokinetic promises. The antineoplastic drug camptothecin was linked to a water-soluble polymeric backbone (MAG-CPT) and administrated as a 30 min infusion
Autor:
D Fraier, Koopman Fj, E. Frigerio, J. M. Meerum Terwogt, Jan H.M. Schellens, Hilde Rosing, M. Rocchetti, W.W. ten Bokkel Huinink, Jos H. Beijnen
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 23:1233-1251
A high-performance liquid chromatographic (HPLC) assay has been designed for the quantitative determination of polymer-bound paclitaxel (after hydrolytic release of paclitaxel from the polymer) and free paclitaxel in human plasma after intravenous ad
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 22:505-514
A high throughput, selective and sensitive high-performance liquid chromatographic (HPLC) method for the determination of a water-soluble polymer-bound Camptothecin conjugate (MAG-CPT) and Camptothecin (CPT) in dog plasma has been developed and valid
Autor:
Alison H. Thomson, D Fraier, Jim Cassidy, Lilian S. Murray, Paul A. Vasey, E. Frigerio, C Twelves
Publikováno v:
British Journal of Cancer
Doxorubicin pharmacokinetics were determined in 33 patients with solid tumours who received intravenous doses of 20–320 mg m−2 HPMA copolymer bound doxorubicin (PK1) in a phase I study. Since assay constraints limited the data at lower doses, con
Akademický článek
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Publikováno v:
Journal of Chromatography A. 797:295-303
A sensitive and selective high-performance liquid chromatographic method for the determination of PNU 166945, a new polymer-bound paclitaxel derivative, free paclitaxel and 7-epipaclitaxel in dog plasma and urine has been developed. The method involv
Publikováno v:
Journal of Antimicrobial Chemotherapy. 34:600-603