Zobrazeno 1 - 10
of 275
pro vyhledávání: '"D, Forsythe"'
Autor:
Steven D. Forsythe, Richard A. Erali, Nicholas Edenhoffer, William Meeker, Nadeem Wajih, Cecilia R. Schaaf, Preston Laney, Cristian D. Vanezuela, Wencheng Li, Edward A. Levine, Shay Soker, Konstantinos I. Votanopoulos
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Peritoneal mesothelioma (PM) is a rare malignancy with poor prognosis, representing about 10–15% of all mesothelioma cases. Herein we apply PM patient-derived tumor organoids (PTOs) in elucidating personalized HIPEC responses to bypass rar
Externí odkaz:
https://doaj.org/article/b06ce63a27604f8892e9538a0600cbd8
Autor:
Steven D. Forsythe, Richard A. Erali, Preston Laney, Hemamylammal Sivakumar, Wencheng Li, Aleksander Skardal, Shay Soker, Konstantinos I. Votanopoulos
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Merkel cell carcinoma (MCC) is a rare neuroendocrine cutaneous cancer, with incidence of less than 1/100,000, low survival rates and variable response to chemotherapy or immunotherapy. Herein we explore the application of patient tumor organ
Externí odkaz:
https://doaj.org/article/b1099e5798d44799b77029561bf17af0
Publikováno v:
GCB Bioenergy, Vol 14, Iss 1, Pp 24-36 (2022)
Abstract Bioenergy has been identified as a key component of climate change mitigation. Therefore, quantifying the net carbon balance of bioenergy feedstocks is crucial for accurate projections of climate mitigation benefits. Switchgrass (Panicum vir
Externí odkaz:
https://doaj.org/article/628ef482eb6340169de7873c136c0bf3
Publikováno v:
Cancers, Vol 15, Iss 15, p 3756 (2023)
Pancreatic neuroendocrine neoplasms (pNENs) are a heterogeneous group of tumors derived from multiple neuroendocrine origin cell subtypes. Incidence rates for pNENs have steadily risen over the last decade, and outcomes continue to vary widely due to
Externí odkaz:
https://doaj.org/article/5b7816c5df854657a7e630370325f898
Autor:
Amy Richardson, Victoria Ciampani, Mihai Stancu, Kseniia Bondarenko, Sherylanne Newton, Joern R Steinert, Nadia Pilati, Bruce P Graham, Conny Kopp-Scheinpflug, Ian D Forsythe
Publikováno v:
eLife, Vol 11 (2022)
Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting fast spikes and high repetition rates. Of the four Kv3 gene family members, Kv3.1 and Kv3.3 are highly expressed in the auditory brainstem and we exploited thi
Externí odkaz:
https://doaj.org/article/7a5ebf62e769488487d88c858f972480
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
Nitric oxide (NO) is of fundamental importance in regulating immune, cardiovascular, reproductive, neuromuscular, and nervous system function. It is rapidly synthesized and cannot be confined, it is highly reactive, so its lifetime is measured in sec
Externí odkaz:
https://doaj.org/article/44de22f0a07d40abaf3f99a568fce089
Autor:
Konstantinos I. Votanopoulos, Shay Soker, Edward A. Levine, Perry Shen, Lance D. Miller, Ralph D'Agostino, Ethan Shelkey, Preston Laney, Shyama Sasikumar, Richard A. Erali, Steven D. Forsythe
Purpose:Immunotherapy efficacy data on appendiceal cancer from clinical trials does not exist, due to appendiceal cancer incidence of 0.97 per 100,000. The goal of this study was to preclinically explore the application of immunotherapy in treating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5212d1f25eabfc5b6bff502449e9db92
https://doi.org/10.1158/1078-0432.c.6530438.v1
https://doi.org/10.1158/1078-0432.c.6530438.v1
Autor:
Konstantinos I. Votanopoulos, Shay Soker, Edward A. Levine, Perry Shen, Lance D. Miller, Ralph D'Agostino, Ethan Shelkey, Preston Laney, Shyama Sasikumar, Richard A. Erali, Steven D. Forsythe
Flow cytometry analysis of CD8+ T-cells after co-culture with tumor cells in organoids for 1 week.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b860fda81c049f8995c098d4977183c
https://doi.org/10.1158/1078-0432.22480388
https://doi.org/10.1158/1078-0432.22480388
Autor:
Cristian D. Valenzuela, Ian B. Solsky, Richard A. Erali, Steven D. Forsythe, Christopher W. Mangieri, Bigyan B. Mainali, Gregory Russell, Kathleen C. Perry, Konstantinos I. Votanopoulos, Perry Shen, Edward A. Levine
Publikováno v:
Ann Surg Oncol
BACKGROUND. Malignant peritoneal mesothelioma (MPM) is a rare diagnosis with a dismal prognosis if untreated. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is shown to significantly improve survival. Our institution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db5f7114b24632004d53643d2f3f11f
https://europepmc.org/articles/PMC10249750/
https://europepmc.org/articles/PMC10249750/
Publikováno v:
Data, Vol 5, Iss 4, p 97 (2020)
Coastal ecosystems are vulnerable to climate change and have been identified as sources of uncertainty in the global carbon budget. Here we introduce a recently established mesonet of eddy covariance towers in South Carolina and describe the sensor a
Externí odkaz:
https://doaj.org/article/2bd7da81e72c425089235184100f8ebd