Zobrazeno 1 - 10
of 159
pro vyhledávání: '"D, Flach"'
Autor:
Judith H. I. Haarhuis, Robin H. van der Weide, Vincent A. Blomen, Koen D. Flach, Hans Teunissen, Laureen Willems, Thijn R. Brummelkamp, Benjamin D. Rowland, Elzo de Wit
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The link between 3D genome architecture and gene expression is still far from resolved. Here the authors show that loss of the CDK catalytic subunit of the Mediator complex results in heterochromatic silencing, which can be rescued by stabilization o
Externí odkaz:
https://doaj.org/article/ec4e2c2fb27a4c92a19bfc6346c64a97
Autor:
Carlo Palmieri, Simak Ali, Jason S. Carroll, R. Charles Coombes, Ian O. Ellis, Jacqui Shaw, Steve Chan, Ingrid Hofland, Marjolein Droog, Mark Opdam, Ekaterina Nevedomskaya, David Moore, Sander Canisius, Ondrej Gojis, Tarek M.A. Abdel-Fatah, Bharath Rudraraju, Koen D. Flach, Wilbert Zwart
Purpose: The steroid receptor coactivator SRC3 is essential for the transcriptional activity of estrogen receptor α (ERα). SRC3 is sufficient to cause mammary tumorigenesis, and has also been implicated in endocrine resistance. SRC3 is posttranslat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c4e5f6d5e0788c176a898c124b677b
https://doi.org/10.1158/1078-0432.c.6524240.v1
https://doi.org/10.1158/1078-0432.c.6524240.v1
Autor:
Carlo Palmieri, Simak Ali, Jason S. Carroll, R. Charles Coombes, Ian O. Ellis, Jacqui Shaw, Steve Chan, Ingrid Hofland, Marjolein Droog, Mark Opdam, Ekaterina Nevedomskaya, David Moore, Sander Canisius, Ondrej Gojis, Tarek M.A. Abdel-Fatah, Bharath Rudraraju, Koen D. Flach, Wilbert Zwart
Tumour biomarkers and correlation with SRC3 and SRC3-pS543
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a3abf8f5fc002d14f182448308c5e3
https://doi.org/10.1158/1078-0432.22459541
https://doi.org/10.1158/1078-0432.22459541
Autor:
Carlo Palmieri, Simak Ali, Jason S. Carroll, R. Charles Coombes, Ian O. Ellis, Jacqui Shaw, Steve Chan, Ingrid Hofland, Marjolein Droog, Mark Opdam, Ekaterina Nevedomskaya, David Moore, Sander Canisius, Ondrej Gojis, Tarek M.A. Abdel-Fatah, Bharath Rudraraju, Koen D. Flach, Wilbert Zwart
S1: Image of full size blot for figure 1A; S2: Image of full size blot for figure 1B; S3: SRC3-pS543 and SRC3 chromatin binding patterns in MCF7 cells; S4: Venn diagram of SRC1, SRC2 and SRC3-pS543 enriched binding sites; S5: A. ChIP-QPCR validation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4097dc48dc93a9a3f3e55cced8b9645
https://doi.org/10.1158/1078-0432.22459562.v1
https://doi.org/10.1158/1078-0432.22459562.v1
Autor:
Carlo Palmieri, Simak Ali, Jason S. Carroll, R. Charles Coombes, Ian O. Ellis, Jacqui Shaw, Steve Chan, Ingrid Hofland, Marjolein Droog, Mark Opdam, Ekaterina Nevedomskaya, David Moore, Sander Canisius, Ondrej Gojis, Tarek M.A. Abdel-Fatah, Bharath Rudraraju, Koen D. Flach, Wilbert Zwart
Figure and table legends for supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772bba8f38e17146b0f74f0ff55b50d6
https://doi.org/10.1158/1078-0432.22459565
https://doi.org/10.1158/1078-0432.22459565
Autor:
Wilbert Zwart, Flora E. van Leeuwen, Lodewyk Wessels, Sabine C. Linn, Hester van Boven, Petra Nederlof, Marian J. Mourits, Harry Hollema, Gwen Dackus, Michael Hauptmann, Patrycja Gradowska, Karianne Schuurman, Mark Opdam, Koen D. Flach, Tesa Severson, Yongsoo Kim, Ekaterina Nevedomskaya, Marjolein Droog
Tamoxifen, a small-molecule antagonist of the transcription factor estrogen receptor alpha (ERα) used to treat breast cancer, increases risks of endometrial cancer. However, no parallels of ERα transcriptional action in breast and endometrial tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8de043883b2d227377c85d6fb26db3b4
https://doi.org/10.1158/0008-5472.c.6507594.v1
https://doi.org/10.1158/0008-5472.c.6507594.v1
Autor:
Wilbert Zwart, Flora E. van Leeuwen, Lodewyk Wessels, Sabine C. Linn, Hester van Boven, Petra Nederlof, Marian J. Mourits, Harry Hollema, Gwen Dackus, Michael Hauptmann, Patrycja Gradowska, Karianne Schuurman, Mark Opdam, Koen D. Flach, Tesa Severson, Yongsoo Kim, Ekaterina Nevedomskaya, Marjolein Droog
Primer sequences corresponding with supplemental figure S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ffa605d879158f94a7f4c1385da743
https://doi.org/10.1158/0008-5472.22408695
https://doi.org/10.1158/0008-5472.22408695
Autor:
Wilbert Zwart, Flora E. van Leeuwen, Lodewyk Wessels, Sabine C. Linn, Hester van Boven, Petra Nederlof, Marian J. Mourits, Harry Hollema, Gwen Dackus, Michael Hauptmann, Patrycja Gradowska, Karianne Schuurman, Mark Opdam, Koen D. Flach, Tesa Severson, Yongsoo Kim, Ekaterina Nevedomskaya, Marjolein Droog
Kaplan-Meier survival plot of endometrial cancer patients who were not treated with tamoxifen for their breast cancer, categorized as ERalpha+/FOXA1+, ERalpha+/FOXA1-, ERalpha-/FOXA1+ or ERalpha-/FOXA1-.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8683cbe6722a3e66998deaed05551476
https://doi.org/10.1158/0008-5472.22408719.v1
https://doi.org/10.1158/0008-5472.22408719.v1
Autor:
Wilbert Zwart, Flora E. van Leeuwen, Lodewyk Wessels, Sabine C. Linn, Hester van Boven, Petra Nederlof, Marian J. Mourits, Harry Hollema, Gwen Dackus, Michael Hauptmann, Patrycja Gradowska, Karianne Schuurman, Mark Opdam, Koen D. Flach, Tesa Severson, Yongsoo Kim, Ekaterina Nevedomskaya, Marjolein Droog
supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca03cb0a5767a9c0334362989357938
https://doi.org/10.1158/0008-5472.22408686
https://doi.org/10.1158/0008-5472.22408686
Autor:
Wilbert Zwart, Flora E. van Leeuwen, Lodewyk Wessels, Sabine C. Linn, Hester van Boven, Petra Nederlof, Marian J. Mourits, Harry Hollema, Gwen Dackus, Michael Hauptmann, Patrycja Gradowska, Karianne Schuurman, Mark Opdam, Koen D. Flach, Tesa Severson, Yongsoo Kim, Ekaterina Nevedomskaya, Marjolein Droog
legends to supplementary tables and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b978c395190c3f8992a5510bf8ce5c4
https://doi.org/10.1158/0008-5472.22408689
https://doi.org/10.1158/0008-5472.22408689