A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation

Autor: K Kollmann, W Warsch, C Gonzalez-Arias, F L Nice, E Avezov, J Milburn, J Li, D Dimitropoulou, S Biddie, M Wang, E Poynton, M Colzani, M R Tijssen, S Anand, U McDermott, B Huntly, T Green

Publikováno v: Kollmann, K, Warsch, W, Gonzalez-Arias, C, Nice, F L, Avezov, E, Milburn, J, Li, J, Dimitropoulou, D, Biddie, S, Wang, M, Poynton, E, Colzani, M, Tijssen, M R, Anand, S, McDermott, U, Huntly, B & Green, T 2017, ' A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation ', Leukemia, vol. 31, no. 4, pp. 934-944 . https://doi.org/10.1038/leu.2016.280
Leukemia

Most myeloproliferative neoplasm (MPN) patients lacking JAK2 mutations harbour somatic CALR mutations that are thought to activate cytokine signalling although the mechanism is unclear. To identify kinases important for survival of CALR-mutant cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::64fc6363344fd1a5c016cf0ddbaeb804
https://www.repository.cam.ac.uk/handle/1810/261276

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2

Autor: Mark Maddison, Heather P. Harding, Ming-Qing Du, Athar Aziz, David Bloxham, Kate Hill, Brian J. P. Huntly, Paola Guglielmelli, Charles E. Massie, David G. Kent, Bruce W. S. Robinson, Kim Orchard, Edward Avezov, Gunes Gundem, Nicholas C.P. Cross, Jonathon Hinton, Jyoti Nangalia, P Van Loo, David Ron, L. Mudie, Sarah O’Meara, E J Baxter, Stephen J. Loughran, Anthony R. Green, Christina A. Ortmann, Claire N. Harrison, Clodagh Keohane, David R. Jones, Karoline Kollmann, Anna L. Godfrey, David C. Wedge, D. Dimitropoulou, Inigo Martincorena, M. Bianchi, Alessandro M. Vannucchi, Mel Greaves, Juan Li, Cathy MacLean, Elli Papaemmanuil, Peter J. Campbell, Amy V. Jones, P. S. Tarpey, Keiran Raine, David G. Bowen, Francesca L. Nice, Yvonne Silber, Adam Butler, Jon W. Teague, Sudhir Tauro, J.D. Fitzpatrick, Stuart McLaren, C.T. Goudie

Publikováno v: The New England Journal of Medicine, 369, 25, pp. 2391-405
The New England Journal of Medicine, 369, 2391-405

Item does not contain fulltext BACKGROUND: Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is obscure, and the diagnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac0501a77ea3dce575fb3007c9b5580
https://hdl.handle.net/2066/126260

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