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Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells

Autor: Mark Fitch, Sharon E. Fleming, John D. Cremin

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 285:G105-G114

Ammonia decreased metabolism by rat colonic epithelial cells of butyrate and acetate to CO2and ketones but increased oxidation of glucose and glutamine. Ammonia decreased cellular concentrations of oxaloacetate for all substrates evaluated. The exten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aca6b0cab8adb945b635e12c85a565e
https://doi.org/10.1152/ajpgi.00437.2002

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In vitro vs in vivo Pb effects on brain protein kinase C activity

Autor: John D. Cremin, Donald R. Smith

Publikováno v: Environmental Research. 90:191-199

Alteration of normal protein kinase C (PKC) function by environmental Pb exposure during neurodevelopment is hypothesized to be an important mechanism of toxicity underlying neurologic impairment. Previous studies have reported widely varying effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd775226ded8900471b9e6c28737aa0f
https://doi.org/10.1016/s0013-9351(02)00007-5

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Oral succimer decreases the gastrointestinal absorption of lead in juvenile monkeys

Autor: Nellie K. Laughlin, John D. Cremin, Donald R. Smith, Melissa L. Luck

Publikováno v: Environmental Health Perspectives

Although succimer (Chemet, meso-2,3-dimercaptosuccinic acid, DMSA) is considered to be a safe and effective chelating agent for the treatment of lead poisoning in humans, there is concern that it may increase the gastrointestinal (GI) absorption and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b8be378a3a5dc07831bd30179a8414
https://doi.org/10.1289/ehp.01109613

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Efficacy of Succimer Chelation for Reducing Brain Lead in a Primate Model of Human Lead Exposure

Autor: John D. Cremin, Nellie K. Laughlin, Donald R. Smith, Melissa L. Luck

Publikováno v: Toxicology and Applied Pharmacology. 161:283-293

The extent to which succimer (meso-2,3-dimercaptosuccinic acid [DMSA], Chemet) reduces brain lead (Pb) levels may be a primary consideration in evaluating its efficacy for reducing neurotoxicity. Clinical research in this area has been hampered by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897446809dd6ad6c3026ea2dea4e48db
https://doi.org/10.1006/taap.1999.8807

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Glycolysis is a source of pyruvate for transamination of glutamine amino nitrogen in jejunal epithelial cells

Autor: Sharon E. Fleming, John D. Cremin

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 272:G575-G588

Previous research has shown that glucose increases transamination of glutamine amino nitrogen with pyruvate. It is unclear whether glucose or glutamine provides the pyruvate used for transamination. In the current study, it was hypothesized that gluc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1034610b050bf94a513452784bb32257
https://doi.org/10.1152/ajpgi.1997.272.3.g575

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Portal and hepatic fluxes in sheep and concentrations in cattle ruminal fluid of 3-(4-hydroxyphenyl)propionic, benzoic, 3-phenylpropionic, and trans-cinnamic acids1

Autor: George C. Fahey, A. L. Goetsch, Kyle R. McLeod, Leslie D. Bourquin, David L. Harmon, J. D. Cremin

Publikováno v: Journal of Animal Science. 73:1766-1775

Extraction methods and HPLC procedures were developed for analysis of potential ruminal metabolites of dietary phenolics (reduced phenolics). Hepatic portal venous blood from wethers fed bromegrass, bermudagrass, ryegrass-wheat, and alfalfa hays also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79393bf8756bd7868b234017cdfaae9c
https://doi.org/10.2527/1995.7361766x

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Prenatal androgenization of lambs: II. Metabolism in adipose tissue and liver1

Autor: Larry L. Berger, James K. Drackley, Xi Lin, L. R. Hansen, D. E. Grum, J. D. Cremin, Jack Odle

Publikováno v: Journal of Animal Science. 73:1701-1712

In vitro measurements of metabolism were made in subcutaneous and perirenal adipose tissue (AT) and liver from prenatally androgenized ewe lambs (TE), control ewe lambs (CE), and control wether lambs (CW). In adipose tissue slices, release of glycero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f14e5c227eaf27811c4769c605437ae4
https://doi.org/10.2527/1995.7361701x

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Effect of roasting on site and extent of digestion of soybean meal by sheep: I. Digestion of nitrogen and amino acids

Autor: Larry L. Berger, Neal R Merchen, J. D. Cremin, B. Demjanec, C. G. Aldrich

Publikováno v: Journal of Animal Science. 73:824-834

Six mature wethers (BW 72 kg) with ruminal, duodenal, and ileal cannulas were fed a control (no added soybean meal [SBM]) diet or diets containing unheated SBM or SBM roasted at 165 degrees C for 75, 150, 180, or 210 min in a 6 x 6 Latin square exper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07eec533c6411d65c0346638bfc96d3
https://doi.org/10.2527/1995.733824x

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