Zobrazeno 1 - 10
of 333
pro vyhledávání: '"D, Conte Camerino"'
Autor:
Lucia Morandi, J. F. Desaphy, D. Conte Camerino, G. Lauria Pinter, Gabriele Siciliano, Giuseppe Felice Mangiatordi, Domenico Alberga, Lorenzo Maggi, Renato Mantegazza, Maria Maddalena Dinardo, Pia Bernasconi, G. Annicchiarico, Giulia Ricci, R. Micheli, Orazio Nicolotti, Concetta Altamura, Gianluca Lattanzi, Paola Imbrici, Raffaella Brugnoni
Publikováno v:
The Journal of Physiology. 593:4181-4199
Key points Loss-of-function mutations of the skeletal muscle ClC-1 channel cause myotonia congenita with variable phenotypes. Using patch clamp we show that F484L, located in the conducting pore, probably induces mild dominant myotonia by right-shift
Autor:
J. F. Desaphy, Emanuela Longa, Rizwan Qaisar, Monica Canepari, Valentina Agoni, Roberto Bottinelli, D. Conte Camerino, Manuela Maffei
Publikováno v:
Acta Physiologica. 212:316-329
Aim Notwithstanding the widely accepted idea that following disuse skeletal muscles become faster, an increase in shortening velocity was previously observed mostly in fibres containing type 1 myosin, whereas a decrease was generally found in fibres
Autor:
J. F. Desaphy, D. Conte Camerino, Teresa Costanza, Alfred L. George, Carlo Franchini, Claudio Bruno, Giovanni Lentini, Antonella Dipalma
Publikováno v:
British Journal of Pharmacology. 160:1521-1533
Background and purpose: Pilsicainide, an anti-arrhythmic drug used in Japan, is described as a pure sodium channel blocker. We examined the mechanisms by which it is able to block open channels, because these properties may be especially useful to re
Autor:
J. F. Desaphy, D. Conte Camerino, Giulia Maria Camerino, Alfred L. George, Jean-Francois Rolland, Antonella Liantonio, A. De Luca, Sabata Pierno, Jennifer D. Kunic, V. Cippone, Gianpatrizio Bianco
Publikováno v:
British Journal of Pharmacology. 156:1206-1215
Background and purpose: Statins and fibrates can produce mild to life-threatening skeletal muscle damage. Resting chloride channel conductance (gCl), carried by the ClC-1 channel, is reduced in muscles of rats chronically treated with fluvastatin, at
Autor:
Antonella Liantonio, Alessandra Picollo, Michael Pusch, D. Conte Camerino, Viviana Giannuzzi, Elena Babini
Publikováno v:
British Journal of Pharmacology. 150:235-247
Background and purpose: Given the crucial role of the skeletal muscle chloride conductance (gCl), supported by the voltage- gated chloride channel CLC-1, in controlling muscle excitability, the availability of ligands modulating CLC-1 are of potentia
Autor:
D. Conte Camerino, Antonio Laghezza, J-F Rolland, Fulvio Loiodice, Domenico Tricarico, Vincenzo Tortorella
Publikováno v:
British Journal of Pharmacology. 149:870-879
Background and purpose: The 2-propyl-1,4 benzoxazine (AM10) shows a peculiar behaviour in skeletal muscle, inhibiting or opening the ATP-sensitive K+ (KATP) channel in the absence and presence of ATP, respectively. We focused on tissue selectivity an
Autor:
D De Vito, Giulia Chiesa, D. Conte Camerino, Caterina Rizzo, Eugenio Scanziani, Maria Svelto, V. Cippone, A. De Luca, Michela Pisoni, Sabata Pierno, Antonio Frigeri, Grazia Paola Nicchia, Cesare R. Sirtori, Maria Paola Didonna
Publikováno v:
British Journal of Pharmacology. 149:909-919
Background and purpose: Skeletal muscle injury by hypolipidemic drugs is not fully understood. An extensive analysis of the effect of chronic treatment with fluvastatin (5 mgkg-1 and 20 mgkg-1), atorvastatin (10 mgkg-1) and fenofibrate (60 mgkg-1) on
Autor:
Maria Maddalena Cavalluzzi, Vincenzo Tortorella, A. De Luca, D. Conte Camerino, Francesco Rana, Giovanni Lentini, Carlo Franchini, Alessia Catalano, M. De Bellis
Publikováno v:
British Journal of Pharmacology. 149:300-310
Background and purpose: Mexiletine (Mex), an orally effective antiarrhythmic agent used to treat ventricular arrhythmias, has also been found to be effective for myotonia and neuropathic pain. It is extensively metabolized in humans but little inform
Autor:
Delia Mitolo-Chieppa, A. L. Piepoli, G. Renna, C. I. Mitolo, M. A. De Salvia, L. Natale, Jean-François Desaphy, G. De Salvatore, D. Conte-Camerino
Publikováno v:
Autonomic and Autacoid Pharmacology. 24:45-54
Summary 1 Prolonged bed rest or exposure to microgravity may cause several alterations in autonomic nervous system response (ANSR). 2 Hindlimb unloading (HU) rats were used as an animal model of simulated microgravity to investigate ANSR changes. The
Autor:
Michela De Bellis, Carlo Franchini, Jean-François Desaphy, Filomena Corbo, S. Talon, Alessia Catalano, Vincenzo Tortorella, D. Conte-Camerino, Annamaria De Luca, Giovanni Lentini
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 367:318-327
In striated fibers, the activity of mexiletine (Mex)-like sodium channel blockers is strongly modulated by the part of the molecule nearby the asymmetric carbon atom. A lipophilic aromatic phenyl group at this levels, as in 2-(2,6-dimethylphenoxy)-1-