Zobrazeno 1 - 10
of 1 145
pro vyhledávání: '"D, Conrad"'
Autor:
Alexandra B. Ysasi, Anna E. Engler, Pushpinder Singh Bawa, Feiya Wang, Regan D. Conrad, Anthony K. Yeung, Jason R. Rock, Jennifer Beane-Ebel, Sarah A. Mazzilli, Ruth A. Franklin, Joseph P. Mizgerd, George J. Murphy
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110169- (2024)
Summary: Macrophages are critical for maintenance and repair of mucosal tissues. While functionally distinct subtypes of macrophage are known to have important roles in injury response and repair in the lungs, little is known about macrophages in the
Externí odkaz:
https://doaj.org/article/5b903bda8cf440d19e820e282f3de643
Autor:
Patrick K. Tumwebaze, Melissa D. Conrad, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Thomas Katairo, Jennifer Legac, Shreeya Garg, David Giesbrecht, Sawyer R. Smith, Frida G. Ceja, Samuel L. Nsobya, Jeffrey A. Bailey, Roland A. Cooper, Philip J. Rosenthal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
In this work, susceptibilities to two key antimalarials, dihydroartemisinin and lumefantrine, were associated with multiple genetic polymorphisms in Plasmodium falciparum, and were lower in northern Uganda, where resistance-mediating mutations have e
Externí odkaz:
https://doaj.org/article/187a57e02f454e7cb07950de76fde6a6
Publikováno v:
PeerJ, Vol 11, p e15597 (2023)
The core promoter elements are important DNA sequences for the regulation of RNA polymerase II transcription in eukaryotic cells. Despite the broad evolutionary conservation of these elements, there is extensive variation in the nucleotide compositio
Externí odkaz:
https://doaj.org/article/1063db0e74c44bc6a7e1b095dcc73e20
Autor:
Oriana Kreutzfeld, Patrick K. Tumwebaze, Martin Okitwi, Stephen Orena, Oswald Byaruhanga, Thomas Katairo, Melissa D. Conrad, Stephanie A. Rasmussen, Jennifer Legac, Ozkan Aydemir, David Giesbrecht, Barbara Forte, Peter Campbell, Alasdair Smith, Hiroki Kano, Samuel L. Nsobya, Benjamin Blasco, Maelle Duffey, Jeffrey A. Bailey, Roland A. Cooper, Philip J. Rosenthal
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Malaria, especially Plasmodium falciparum infection, remains an enormous problem, and its treatment and control are seriously challenged by drug resistance. New antimalarial drugs are needed. To characterize the Medicines for Malaria Venture
Externí odkaz:
https://doaj.org/article/373b8efbdb7d4e76aea7095c81c6a1bf
Autor:
Cheryl D. Conrad
Publikováno v:
Neurobiology of Stress, Vol 21, Iss , Pp 100482- (2022)
A commentary on ‘Doctor, I am so stressed out!’ A descriptive study of biological, psychological, and socioemotional markers of stress in individuals who self-identify as being ‘very stressed out’ or ‘zen’.
Externí odkaz:
https://doaj.org/article/aa2db82f29964c259e8e2da071055913
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Cybersecurity notifications play an important role in encouraging users to use computers safely. Emotional reactions to such notifications are known to positively influence users’ adherence to these notifications, though it is challenging for resea
Externí odkaz:
https://doaj.org/article/bfb7ed9702b24c6d8fa66c14992cfc12
Autor:
Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K. Tumwebaze, Jennifer Legac, Roland A. Cooper, Philip J. Rosenthal
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-9 (2021)
Abstract Background Anti-malarial drug resistance may be limited by decreased fitness in resistant parasites. Important contributors to resistance are mutations in the Plasmodium falciparum putative drug transporter PfMDR1. Methods Impacts on in vitr
Externí odkaz:
https://doaj.org/article/4efc2707118f4d0781ebdac49229c810
Autor:
Sam L. Nsobya, Andrew Walakira, Elizabeth Namirembe, Moses Kiggundu, Joaniter I. Nankabirwa, Emmanuel Ruhamyankaka, Emmanuel Arinaitwe, Melissa D. Conrad, Moses R. Kamya, Grant Dorsey, Philip J. Rosenthal
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-6 (2021)
Abstract Background Rapid diagnostic tests (RDTs) play a key role in malaria case management. The most widely used RDT identifies Plasmodium falciparum based on immunochromatographic recognition of P. falciparum histidine-rich protein 2 (PfHRP2). Del
Externí odkaz:
https://doaj.org/article/f47ea82463444c419018d31e5abc4629
Autor:
Alex K. Musiime, David L. Smith, Maxwell Kilama, Otto Geoffrey, Patrick Kyagamba, John Rek, Melissa D. Conrad, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Anne M. Akol, Moses R. Kamya, Grant Dorsey, Sarah G. Staedke, Chris Drakeley, Steve W. Lindsay
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Abstract Background Over the last two decades, there has been remarkable progress in malaria control in sub-Saharan Africa, due mainly to the massive deployment of long-lasting insecticidal nets and indoor residual spraying. Despite these gains, it i
Externí odkaz:
https://doaj.org/article/41225e80a72a456b9234c18c09d8cc95
Autor:
Alex K Musiime, Paul J Krezanoski, David L Smith, Maxwell Kilama, Melissa D Conrad, Geoffrey Otto, Patrick Kyagamba, Jackson Asiimwe, John Rek, Joaniter I Nankabirwa, Emmanuel Arinaitwe, Anne M Akol, Moses R Kamya, Sarah G Staedke, Chris Drakeley, Teun Bousema, Steve W Lindsay, Grant Dorsey, Lucy S Tusting
Publikováno v:
PLOS Global Public Health, Vol 2, Iss 3, p e0000063 (2022)
House construction is rapidly modernizing across Africa but the potential benefits for human health are poorly understood. We hypothesised that improvements to housing would be associated with reductions in malaria, acute respiratory infection (ARI)
Externí odkaz:
https://doaj.org/article/e748e0541cfb46379cebc4447ac67652