Zobrazeno 1 - 10
of 1 252
pro vyhledávání: '"D, Cohn"'
Autor:
Eleonora Maino, Ori Scott, Samar Z. Rizvi, Wing Suen Chan, Shagana Visuvanathan, Youssif Ben Zablah, Hongbin Li, Ameet S. Sengar, Michael W. Salter, Zhengping Jia, Janet Rossant, Ronald D. Cohn, Bin Gu, Evgueni A. Ivakine
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/102714651e424d538637bc0d58cdac43
Autor:
Sayera Dhaubhadel, Kumkum Ganguly, Ruy M. Ribeiro, Judith D. Cohn, James M. Hyman, Nicolas W. Hengartner, Beauty Kolade, Anna Singley, Tanmoy Bhattacharya, Patrick Finley, Drew Levin, Haedi Thelen, Kelly Cho, Lauren Costa, Yuk-Lam Ho, Amy C. Justice, John Pestian, Daniel Santel, Rafael Zamora-Resendiz, Silvia Crivelli, Suzanne Tamang, Susana Martins, Jodie Trafton, David W. Oslin, Jean C. Beckham, Nathan A. Kimbrel, Million Veteran Program Suicide Exemplar Work Group, Benjamin H. McMahon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract We present an ensemble transfer learning method to predict suicide from Veterans Affairs (VA) electronic medical records (EMR). A diverse set of base models was trained to predict a binary outcome constructed from reported suicide, suicide a
Externí odkaz:
https://doaj.org/article/f6fe8596f4ab4a77a81d71a70bf80892
Autor:
Daniel Vargas P. de Almeida, Justine M. Anderson, Daniel C. Danila, Michael J. Morris, Susan F. Slovin, Wassim Abida, Erica D. Cohn, Raymond E. Baser, Howard I. Scher, Karen A. Autio
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 6, Iss 4, Pp 162-169 (2023)
Introduction: Use of the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) during chemotherapy is associated with decreased hospitalization rates, improved quality of life, and longer survival. Limite
Externí odkaz:
https://doaj.org/article/31114f0b1c6d4458be476309142a3dfb
Autor:
Matthew Rok, Tatianna Wai Ying Wong, Eleonora Maino, Abdalla Ahmed, Grace Yang, Elzbieta Hyatt, Kyle Lindsay, Sina Fatehi, Ryan Marks, Paul Delgado-Olguín, Evgueni A. Ivakine, Ronald D. Cohn
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 246-258 (2023)
Duchenne muscular dystrophy (DMD) is a disease with a life-threatening trajectory resulting from mutations in the dystrophin gene, leading to degeneration of skeletal muscle and fibrosis of cardiac muscle. The overwhelming majority of mutations are m
Externí odkaz:
https://doaj.org/article/f6f44eb7d6ec40c3ab0d3efbe103235b
Autor:
Ori Scott, Shagana Visuvanathan, Emily Reddy, Deeqa Mahamed, Bin Gu, Chaim M. Roifman, Ronald D. Cohn, Cynthia J. Guidos, Evgueni A. Ivakine
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHumans with gain-of-function (GOF) mutations in STAT1 (Signal Transducer and Activator of Transcription 1), a potent immune regulator, experience frequent infections. About one-third, especially those with DNA-binding domain (DBD) mutatio
Externí odkaz:
https://doaj.org/article/a92971508e374a85a787e6e51acaca8e
Autor:
Ori Scott, Kyle Lindsay, Steven Erwood, Antonio Mollica, Chaim M. Roifman, Ronald D. Cohn, Evgueni A. Ivakine
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract Signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) is an autosomal dominant immune disorder marked by wide infectious predisposition, autoimmunity, vascular disease, and malignancy. Its molecular hallmark, elev
Externí odkaz:
https://doaj.org/article/f8847bc7541a4ab68fbd2ae0e0ec203f
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Externí odkaz:
https://doaj.org/article/46abfd4f1b594d25b6ce0147b4f62167
Autor:
Sina Fatehi, Ryan M. Marks, Matthew J. Rok, Lucie Perillat, Evgueni A. Ivakine, Ronald D. Cohn
Publikováno v:
Human Gene Therapy. 34:388-403
Targeted genome editing in vivo corrects a Dmd duplication restoring wild‐type dystrophin expression
Autor:
Eleonora Maino, Daria Wojtal, Sonia L Evagelou, Aiman Farheen, Tatianna W Y Wong, Kyle Lindsay, Ori Scott, Samar Z Rizvi, Elzbieta Hyatt, Matthew Rok, Shagana Visuvanathan, Amanda Chiodo, Michelle Schneeweiss, Evgueni A Ivakine, Ronald D Cohn
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp n/a-n/a (2021)
Abstract Tandem duplication mutations are increasingly found to be the direct cause of many rare heritable diseases, accounting for up to 10% of cases. Unfortunately, animal models recapitulating such mutations are scarce, limiting our ability to stu
Externí odkaz:
https://doaj.org/article/79b8670d90524c9f9b3d247d4ec1653b
Publikováno v:
BMC Bioinformatics, Vol 19, Iss S18, Pp 9-17 (2018)
Abstract Background Histopathology images of tumor biopsies present unique challenges for applying machine learning to the diagnosis and treatment of cancer. The pathology slides are high resolution, often exceeding 1GB, have non-uniform dimensions,
Externí odkaz:
https://doaj.org/article/6fc41530829a40a3a61a915a0f1e5a97