Zobrazeno 1 - 10
of 570
pro vyhledávání: '"D, Burr"'
Autor:
Scott M. Johnson, Hanmei Bao, Cailin E. McMahon, Yongbin Chen, Stephanie D. Burr, Aaron M. Anderson, Katja Madeyski-Bengtson, Daniel Lindén, Xianlin Han, Jun Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The I148M variant of PNPLA3 is closely associated with hepatic steatosis. Recent evidence indicates that the I148M mutant functions as an inhibitor of PNPLA2/ATGL-mediated lipolysis, leaving the role of wild-type PNPLA3 undefined. Despite sh
Externí odkaz:
https://doaj.org/article/446ac4633cd64e55aab1453331558861
Autor:
Beatrix Feigl, Simon J.G. Lewis, Lucy D. Burr, Daniel Schweitzer, Subodh Gnyawali, Dimitrios Vagenas, Drew D. Carter, Andrew J. Zele
Publikováno v:
EClinicalMedicine, Vol 69, Iss , Pp 102474- (2024)
Summary: Background: New non-pharmacological treatments for improving non-motor symptoms in Parkinson's disease (PD) are urgently needed. Previous light therapies for modifying sleep behaviour lacked standardised protocols and were not personalised f
Externí odkaz:
https://doaj.org/article/4e7d9e079fc84023a129c42ded764ebf
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Dietary saturate fatty acids (SFAs) have been consistently linked to atherosclerosis and obesity, both of which are characterized by chronic inflammation and impaired lipid metabolism. In comparison, the effects of linoleic acid (LA), the pr
Externí odkaz:
https://doaj.org/article/44b8a6c2dc654cfdb7f44052e8077c87
Autor:
Jocelyn M. Choo, Alyce M. Martin, Steven L. Taylor, Emily Sun, Fredrick M. Mobegi, Tokuwa Kanno, Alyson Richard, Lucy D. Burr, Stevie Lingman, Megan Martin, Damien J. Keating, A. James Mason, Geraint B. Rogers
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Long-term low-dose macrolide therapy is now widely used in the treatment of chronic respiratory diseases for its immune-modulating effects, although the antimicrobial properties of macrolides can also have collateral impacts on the gut micro
Externí odkaz:
https://doaj.org/article/8d63491e09574059afe8fa5c75bca7a8
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4480 (2022)
Diabetics have an increased risk for heart failure due to cardiac fibroblast functional changes occurring as a result of AGE/RAGE signaling. Advanced glycation end products (AGEs) levels are higher in diabetics and stimulate elevated RAGE (receptor f
Externí odkaz:
https://doaj.org/article/0c426b95b7c1458ab77815edb5053bfa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Diabetic individuals have an increased risk for developing cardiovascular disease due to stiffening of the left ventricle (LV), which is thought to occur, in part, by increased AGE/RAGE signaling inducing fibroblast differentiation. Advanced glycated
Externí odkaz:
https://doaj.org/article/0339271fd0ff4bfdb2c30a551a90fa89
Autor:
Steven L. Taylor, Lex E. X. Leong, Fredrick M. Mobegi, Jocelyn M. Choo, Lucy D. Burr, Steve Wesselingh, Geraint B. Rogers
Publikováno v:
Multidisciplinary Respiratory Medicine, Vol 13, Iss S1, Pp 9-14 (2018)
Abstract Determining the effects of antimicrobial therapies on airway microbiology at a population-level is essential. Such analysis allows, for example, surveillance of antibiotic-induced changes in pathogen prevalence, the emergence and spread of a
Externí odkaz:
https://doaj.org/article/024cea80ce87440ab33144ffa9ec1b2c
Publikováno v:
EvoDevo, Vol 9, Iss 1, Pp 1-15 (2018)
Abstract The anterior neuroectoderm (ANE) in many deuterostome embryos (echinoderms, hemichordates, urochordates, cephalochordates, and vertebrates) is progressively restricted along the anterior–posterior axis to a domain around the anterior pole.
Externí odkaz:
https://doaj.org/article/044fb16565e54de3b789587b62c65e3c
Autor:
Stephanie D. Burr, James A. Stewart
Publikováno v:
Cells, Vol 10, Iss 6, p 1286 (2021)
Cardiovascular disease is a common diabetic complication that can arise when cardiac fibroblasts transition into myofibroblasts. Myofibroblast transition can be induced by advanced glycated end products (AGEs) present in the extracellular matrix (ECM
Externí odkaz:
https://doaj.org/article/ef5cfcde3280401b851d928d9f61c622
Autor:
Stephanie D. Burr, James A. Stewart
Publikováno v:
Cells, Vol 10, Iss 3, p 557 (2021)
Cardiovascular disease, specifically heart failure, is a common complication for individuals with type 2 diabetes mellitus. Heart failure can arise with stiffening of the left ventricle, which can be caused by “active” cardiac fibroblasts (i.e.,
Externí odkaz:
https://doaj.org/article/675d1bba55e14455add46d6fdfa75f37