Zobrazeno 1 - 10
of 2 389
pro vyhledávání: '"D, Buckley"'
Autor:
Georgiana Neag, Jonathan Lewis, Jason D. Turner, Julia E. Manning, Isaac Dean, Melissa Finlay, Gowsihan Poologasundarampillai, Jonathan Woods, Muhammad Arham Sahu, Kabir A. Khan, Jenefa Begum, Helen M. McGettrick, Ilaria Bellantuono, Victoria Heath, Simon W. Jones, Christopher D. Buckley, Roy Bicknell, Amy J. Naylor
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Type-H capillary endothelial cells control bone formation during embryogenesis and postnatal growth but few signalling mechanisms underpinning this influence have been characterised. Here, we identify a highly expressed type-H endothelial ce
Externí odkaz:
https://doaj.org/article/85498a388ee845cc9022af51c103ca92
Publikováno v:
BMJ Open Sport & Exercise Medicine, Vol 10, Iss 3 (2024)
Background Well-being declines during men’s middle years, and while physical activity (PA) can have a positive influence, the type of PA that provides the greatest benefit is not clear. This cross-sectional study explored how participation in diffe
Externí odkaz:
https://doaj.org/article/392d391c03e743058215fa2a8e252b78
Autor:
Michael T. H. Ng, Rowie Borst, Hamez Gacaferi, Sarah Davidson, Jessica E. Ackerman, Peter A. Johnson, Caio C. Machado, Ian Reekie, Moustafa Attar, Dylan Windell, Mariola Kurowska-Stolarska, Lucy MacDonald, Stefano Alivernini, Micon Garvilles, Kathrin Jansen, Ananya Bhalla, Angela Lee, James Charlesworth, Rajat Chowdhury, Paul Klenerman, Kate Powell, Carl-Philip Hackstein, ICECAP Consortium, Dominic Furniss, Jonathan Rees, Derek Gilroy, Mark Coles, Andrew J. Carr, Stephen N. Sansom, Christopher D. Buckley, Stephanie G. Dakin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-i
Externí odkaz:
https://doaj.org/article/0ab5f854810c4af1beacea8e07505eca
Autor:
Susan J. Ward, Alison M. Coates, Sharayah Carter, Katherine L. Baldock, Carolyn Berryman, Tasha R. Stanton, Catherine Yandell, Jonathan D. Buckley, Sze-Yen Tan, Geraint B. Rogers, Alison M. Hill
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
BackgroundThe relationship between adiposity and pain is complex. Excess weight increases the risk for chronic musculoskeletal pain (CMP), driven by increased biomechanical load and low-grade systemic inflammation. Pain limits physical function, impa
Externí odkaz:
https://doaj.org/article/13deff840fe5432595a80cfc562b59c4
Autor:
Jolet Y. Mimpen, Robert Hedley, Anna Ridley, Mathew J. Baldwin, Dylan Windell, Ananya Bhalla, Lorenzo Ramos-Mucci, Christopher D. Buckley, Mark C. Coles, Abtin Alvand, Andrew J. Price, Andrew J. Carr, Stephanie G. Dakin, Sarah J. B. Snelling
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Objectives Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains understudied. This study aim
Externí odkaz:
https://doaj.org/article/ad4812c86da64d16ae2f61590a6143f6
Publikováno v:
BMJ Open, Vol 14, Iss 1 (2024)
Introduction Previous research has associated high dietary cholesterol intake with raised low-density lipoprotein cholesterol (LDL-C) and thus increased risk for cardiovascular disease (CVD). Emerging research suggests that it is saturated fat, not d
Externí odkaz:
https://doaj.org/article/f527b69efb8a4e4ea724ea8edd3c7476
Autor:
Valentina Pucino, Meriam Nefla, Vincent Gauthier, Ghada Alsaleh, Sally A. Clayton, Jennifer Marshall, Andrew Filer, Andy R. Clark, Karim Raza, Christopher D. Buckley
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe synovial membrane is the main site of inflammation in rheumatoid arthritis (RA). Here several subsets of fibroblasts and macrophages, with distinct effector functions, have been recently identified. The RA synovium is hypoxic and acid
Externí odkaz:
https://doaj.org/article/cf1c330f4be2412981ed289d70a14e95
Autor:
Saba Nayar, Elena Pontarini, Joana Campos, Onorina Berardicurti, Charlotte G. Smith, Saba Asam, David H. Gardner, Serena Colafrancesco, Davide Lucchesi, Rachel Coleby, Ming-May Chung, Valentina Iannizzotto, Kelly Hunter, Simon J. Bowman, Gianluca Carlesso, Ronald Herbst, Helen M. McGettrick, Jeff Browning, Christopher D. Buckley, Benjamin A. Fisher, Michele Bombardieri, Francesca Barone
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The study suggests a link between ICOS-ICOSL signaling and LTa3 induction on T cells. LTa3 subsequently activates fibroblasts in the salivary gland, leading to formation of tertiary lymphoid tissues (TLS).
Externí odkaz:
https://doaj.org/article/d98526377cb948829a419d58788242d6
Autor:
Po-Lun Kung, Tsui-Wen Chou, Marissa Lindman, Nydia P. Chang, Irving Estevez, Benjamin D. Buckley, Colm Atkins, Brian P. Daniels
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but serious neurologic dise
Externí odkaz:
https://doaj.org/article/f090e5ef555648819e10f0ae283a147e
Autor:
Olalekan Lee Aiyegbusi, Lavinia Ferrante di Ruffano, Ameeta Retzer, Philip N. Newsome, Christopher D. Buckley, Melanie J. Calvert
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Tissue-agnostic drug development provides a paradigm shift in precision medicine and requires innovative trial designs. However, outcome selection for such trials can prove challenging. The objectives of this review were to: (i) I
Externí odkaz:
https://doaj.org/article/d54d62ce295041858e8b838a735a30e1