Deep-Sea Sponges and Corals off the Western Coast of Florida—Intracellular Mechanisms of Action of Bioactive Compounds and Technological Advances Supporting the Drug Discovery Pipeline

Autor: Mina Iskandar, Kira M. Ruiz-Houston, Steven D. Bracco, Sami R. Sharkasi, Cecilia L. Calabi Villarroel, Meghna N. Desai, Alexandra G. Gerges, Natalia A. Ortiz Lopez, Miguel Xiao Barbero, Amelia A. German, Vinoothna S. Moluguri, Selina M. Walker, Juliana Silva Higashi, Justin M. Palma, Daena Z. Medina, Miit Patel, Prachi Patel, Michaela Valentin, Angelica C. Diaz, Jonathan P. Karthaka, Atzin D. Santiago, Riley B. Skiles, Luis A. Romero Umana, Maxwell D. Ungrey, Anya Wojtkowiak, Domenica V. Howard, Remy Nurge, Katharine G. Woods, Meera Nanjundan

Publikováno v: Marine Drugs, Vol 21, Iss 12, p 615 (2023)

The majority of natural products utilized to treat a diverse array of human conditions and diseases are derived from terrestrial sources. In recent years, marine ecosystems have proven to be a valuable resource of diverse natural products that are ge

Externí odkaz: https://doaj.org/article/53d4c3203f9148e6a94a706813d12a0e

COVID-19 detection and spread control: what initiatives in Italy for the homeless population?

Autor: E, Di Simone, A, De Leo, N, Panattoni, F, Bonfà, M, Tatangelo, V, Tallarita, A R, Buonomini, A, Cristaudo, D, Bracco, F, Petrone, A, Morrone

Publikováno v: European review for medical and pharmacological sciences. 26(1)

In Italy COVID-19 pandemic had a severe impact. The homeless live in situations aggravating their poor health conditions and comorbidities. Although homeless people are a fragile category, no dedicated measures by public health departments seem to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1291a0e6a2b8f3301dab07b18ab7be42
https://pubmed.ncbi.nlm.nih.gov/35302227

Trauma Association of Canada (TAC) Annual Scientific Meeting. The Westin Whistler Resort & Spa, Whistler, BC, Thursday, Apr. 11 to Saturday, Apr. 13, 2013Testing the reliability of tools for pediatric trauma teamwork evaluation in a North American high-resource simulation settingThe association of etomidate with mortality in trauma patientsDefinition of isolated hip fractures as an exclusion criterion in trauma centre performance evaluations: a systematic reviewEstimation of acute care hospitalization costs for trauma hospital performance evaluation: a systematic reviewHospital length of stay following admission for traumatic injury in Canada: a multicentre cohort studyPredictors of hospital length of stay following traumatic injury: a multicentre cohort studyInfluence of the heterogeneity in definitions of an isolated hip fracture used as an exclusion criterion in trauma centre performance evaluations: a multicentre cohort studyPediatric trauma, advocacy skills and medical studentsCompliance with the prescribed packed red blood cell, fresh frozen plasma and platelet ratio for the trauma transfusion pathway at a level 1 trauma centreEarly fixed-wing aircraft activation for major trauma in remote areasDevelopment of a national, multi-disciplinary trauma crisis resource management curriculum: results from the pilot courseThe management of blunt hepatic trauma in the age of angioembolization: a single centre experienceEarly predictors of in-hospital mortality in adult trauma patientsThe impact of open tibial fracture on health service utilization in the year preceding and following injuryA systematic review and meta-analysis of the efficacy of red blood cell transfusion in the trauma populationSources of support for paramedics managing work-related stress in a Canadian EMS service responding to multisystem trauma patientsAnalysis of prehospital treatment of pain in the multisystem trauma patient at a community level 2 trauma centreIncreased mortality associated with placement of central lines during trauma resuscitationChronic pain after serious injury — identifying high risk patientsEpidemiology of in-hospital trauma deaths in a Brazilian university teaching hospitalIncreased suicidality following major trauma: a population-based studyDevelopment of a population-wide record linkage system to support trauma researchInduction of hmgb1 by increased gut permeability mediates acute lung injury in a hemorrhagic shock and resuscitation mouse modelPatients who sustain gunshot pelvic fractures are at increased risk for deep abscess formation: aggravated by rectal injuryAre we transfusing more with conservative management of isolated blunt splenic injury? A retrospective studyMotorcycle clothesline injury prevention: Experimental test of a protective deviceA prospective analysis of compliance with a massive transfusion protocol - activation alone is not enoughAn evaluation of diagnostic modalities in penetrating injuries to the cardiac box: Is there a role for routine echocardiography in the setting of negative pericardial FAST?Achievement of pediatric national quality indicators — an institutional report cardProcess mapping trauma care in 2 regional health authorities in British Columbia: a tool to assist trauma sys tem design and evaluationPatient safety checklist for emergency intubation: a systematic reviewA standardized flow sheet improves pediatric trauma documentationMassive transfusion in pediatric trauma: a 5-year retrospective reviewIs more better: Does a more intensive physiotherapy program result in accelerated recovery for trauma patients?Trauma care: not just for surgeons. Initial impact of implementing a dedicated multidisciplinary trauma team on severely injured patientsThe role of postmortem autopsy in modern trauma care: Do we still need them?Prototype cervical spine traction device for reduction stabilization and transport of nondistraction type cervical spine injuriesGoing beyond organ preservation: a 12-year review of the beneficial effects of a nonoperative management algorithm for splenic traumaAssessing the construct validity of a global disability measure in adult trauma registry patientsThe mactrauma TTL assessment tool: developing a novel tool for assessing performance of trauma traineesA quality improvement approach to developing a standardized reporting format of ct findings in blunt splenic injuriesOutcomes in geriatric trauma: what really mattersFresh whole blood is not better than component therapy (FFP:RBC) in hemorrhagic shock: a thromboelastometric study in a small animal modelFactors affecting mortality of chest trauma patients: a prospective studyLong-term pain prevalence and health related quality of life outcomes for patients enrolled in a ketamine versus morphine for prehospital traumatic pain randomized controlled trialDescribing pain following trauma: predictors of persistent pain and pain prevalenceManagement strategies for hemorrhage due to pelvic trauma: a survey of Canadian general surgeonsMajor trauma follow-up clinic: Patient perception of recovery following severe traumaLost opportunities to enhance trauma practice: culture of interprofessional education and sharing among emergency staffPrehospital airway management in major trauma and traumatic brain injury by critical care paramedicsImproving patient selection for angiography and identifying risk of rebleeding after angioembolization in the nonoperative management of high grade splenic injuriesFactors predicting the need for angioembolization in solid organ injuryProthrombin complex concentrates use in traumatic brain injury patients on oral anticoagulants is effective despite underutilizationThe right treatment at the right time in the right place: early results and associations from the introduction of an all-inclusive provincial trauma care systemA multicentre study of patient experiences with acute and postacute injury carePopulation burden of major trauma: Has introduction of an organized trauma system made a difference?Long-term functional and return to work outcomes following blunt major trauma in Victoria, AustraliaSurgical dilemma in major burns victim: heterotopic ossification of the tempromandibular jointWhich radiological modality to choose in a unique penetrating neck injury: a differing opinionThe Advanced Trauma Life Support (ATLS) program in CanadaThe Rural Trauma Team Development Course (RTTDC) in Pakistan: Is there a role?Novel deployment of BC mobile medical unit for coverage of BMX world cup sporting eventIncidence and prevalence of intra-abdominal hypertension and abdominal compartment syndrome in critically ill adults: a systematic review and meta-analysisRisk factors for intra-abdominal hypertension and abdominal compartment syndrome in critically ill or injured adults: a systematic review and meta-analysisA comparison of quality improvement practices at adult and pediatric trauma centresInternational trauma centre survey to evaluate content validity, usability and feasibility of quality indicatorsLong-term functional recovery following decompressive craniectomy for severe traumatic brain injuryMorbidity and mortality associated with free falls from a height among teenage patients: a 5-year review from a level 1 trauma centreA comparison of adverse events between trauma patients and general surgery patients in a level 1 trauma centreProcoagulation, anticoagulation and fibrinolysis in severely bleeding trauma patients: a laboratorial characterization of the early trauma coagulopathyThe use of mobile technology to facilitate surveillance and improve injury outcome in sport and physical activityIntegrated knowledge translation for injury quality improvement: a partnership between researchers and knowledge usersThe impact of a prevention project in trauma with young and their learningIntraosseus vascular access in adult trauma patients: a systematic reviewThematic analysis of patient reported experiences with acute and post-acute injury careAn evaluation of a world health organization trauma care checklist quality improvement pilot programProspective validation of the modified pediatric trauma triage toolThe 16-year evolution of a Canadian level 1 trauma centre: growing up, growing out, and the impact of a booming economyA 20-year review of trauma related literature: What have we done and where are we going?Management of traumatic flail chest: a systematic review of the literatureOperative versus nonoperative management of flail chestEmergency department performance of a clinically indicated and technically successful emergency department thoracotomy and pericardiotomy with minimal equipment in a New Zealand institution without specialized surgical backupBritish Columbia’s mobile medical unit — an emergency health care support resourceRoutine versus ad hoc screening for acute stress: Who would benefit and what are the opportunities for trauma care?A geographical analysis of the Early Development Instrument (EDI) and childhood injuryDevelopment of a pediatric spinal cord injury nursing course'Kids die in driveways' — an injury prevention campaignEpidemiology of traumatic spine injuries in childrenA collaborative approach to reducing injuries in New Brunswick: acute care and injury preventionImpact of changes to a provincial field trauma triage tool in New BrunswickEnsuring quality of field trauma triage in New BrunswickBenefits of a provincial trauma transfer referral system: beyond the numbersThe field trauma triage landscape in New BrunswickImpact of the Rural Trauma Team Development Course (RTTDC) on trauma transfer intervals in a provincial, inclusive trauma systemTrauma and stress: a critical dynamics study of burnout in trauma centre healthcare professionalsUltrasound-guided pediatric forearm fracture reduction with sedation in the emergency departmentBlock first, opiates later? The use of the fascia iliaca block for patients with hip fractures in the emergency department: a systematic reviewRural trauma systems — demographic and survival analysis of remote traumas transferred from northern QuebecSimulation in trauma ultrasound trainingIncidence of clinically significant intra-abdominal injuries in stable blunt trauma patientsWake up: head injury management around the clockDamage control laparotomy for combat casualties in forward surgical facilitiesDetection of soft tissue foreign bodies by nurse practitioner performed ultrasoundAntihypertensive medications and walking devices are associated with falls from standingThe transfer process: perspectives of transferring physiciansDevelopment of a rodent model for the study of abdominal compartment syndromeClinical efficacy of routine repeat head computed tomography in pediatric traumatic brain injuryEarly warning scores (EWS) in trauma: assessing the 'effectiveness' of interventions by a rural ground transport service in the interior of British ColumbiaAccuracy of trauma patient transfer documentation in BCPostoperative echocardiogram after penetrating cardiac injuries: a retrospective studyLoss to follow-up in trauma studies comparing operative methods: a systematic reviewWhat matters where and to whom: a survey of experts on the Canadian pediatric trauma systemA quality initiative to enhance pain management for trauma patients: baseline attitudes of practitionersComparison of rotational thromboelastometry (ROTEM) values in massive and nonmassive transfusion patientsMild traumatic brain injury defined by GCS: Is it really mild?The CMAC videolaryngosocpe is superior to the glidescope for the intubation of trauma patients: a prospective analysisInjury patterns and outcome of urban versus suburban major traumaA cost-effective, readily accessible technique for progressive abdominal closureEvolution and impact of the use of pan-CT scan in a tertiary urban trauma centre: a 4-year auditAdditional and repeated CT scan in interfacilities trauma transfers: room for standardizationPediatric trauma in situ simulation facilitates identification and resolution of system issuesHospital code orange plan: there’s an app for thatDiaphragmatic rupture from blunt trauma: an NTDB studyEarly closure of open abdomen using component separation techniqueSurgical fixation versus nonoperative management of flail chest: a meta-analysisIntegration of intraoperative angiography as part of damage control surgery in major traumaMass casualty preparedness of regional trauma systems: recommendations for an evaluative frameworkDiagnostic peritoneal aspirate: An obsolete diagnostic modality?Blunt hollow viscus injury: the frequency and consequences of delayed diagnosis in the era of selective nonoperative managementEnding 'double jeopardy:' the diagnostic impact of cardiac ultrasound and chest radiography on operative sequencing in penetrating thoracoabdominal traumaAre trauma patients with hyperfibrinolysis diagnosed by rotem salvageable?The risk of cardiac injury after penetrating thoracic trauma: Which is the better predictor, hemodynamic status or pericardial window?The online Concussion Awareness Training Toolkit for health practitioners (CATT): a new resource for recognizing, treating, and managing concussionThe prevention of concussion and brain injury in child and youth team sportsRandomized controlled trial of an early rehabilitation intervention to improve return to work Rates following road traumaPhone call follow-upPericardiocentesis in trauma: a systematic review

Autor: T. Lee, A. Jackson, S. Faux, S. Lockhart, S. Babul, T. Zakrison, A. Sankarankutty, R. Berg, E. Joos, B. Heidary, J. Spicer, G. Slobogean, M. Alhabboubi, N. Nash, D. Bracco, K. Bailey, Y. Lin, M. Azzam, J. Rezende-Neto, T. O’Keeffe, B. Joseph, P. Veigas, K. Nixon, A. Harrington, B. Kidane, B. Al Bader, N. Bradley, L. Takeuchi, S. Chadi, N. Sathivel, F. Muakkassa, P. Atkinson, J. Doucet, J. Fraser, F. Hamadani, A. Chesters, M. Howlett, I. Watson, R. Boulay, A. Hogan, S. Woodford, S. Bressan, H. Jowett, N. Bell, R. Brown, A. Brainard, Y. Almarhabi, F. Pervaiz, G. Gamme, D. Das, D. Davies, R. Zakirova, N. Bobrovitz, K. Birn, A. Dorigatti, M.J. Santana, J. Banfield, L.T. Da Luz, M. Waggott, J. Hodgkinson, K. Kruger, C. Cooper, J. Holodinsky, D. Roberts, M. Grant, J. Ali, B.J. Gabbe, J. Mckee, A. Alburakan, E. Vu, J. Riley, K. Hoffman, B. Mador, P. Jennings, E. Aleassa, C.M. Lee, N. Alonazi, S. Reid, O. Williamson, W. Leeper, M. Boitano, P. Lubbert, J. Hsu, S. Calthorpe, M. Livingston, D. Andrusiek, G. Jansz, S. Alzaid, K. Vogt, Y. Leblanc, R. Kao, R. Lyons, J. March, A. Trajano, A. Holmes, P. Bradford, S. Patel, I. Pallister, P. Lysecki, K. Bartens, L. Gillman, S. Wheeler, B. Moffatt, C. Wang, J. Tiao, L. Moore, V. Porgo, C. Hinkewich, G. Hoit, J. Pemberton, R. Green, J. Tallon, A. Turgeon, A. Boutin, D. Reinartz, G. Lapointe, H.T. Stelfox, A. Nathens, X. Neveu, I. Bratu, C. Gladwin, D. Voaklander, M. Lewis, K. Eckert, J. Williamson, T. Charyk Stewart, N. Parry, D. Gray, R. L’Heureux, M. Ziesmann, J. Kortbeek, P. Brindley, C. Hicks, P. Fata, P. Engels, C. Ball, D. Paton-Gay, S. Widder, R. Hernandez-Alejandro, L. Vanderbeek, F. Forrokhyar, R. Anatharajah, N. Howatt, S. Lamb, N. Sne, K. Kahnamoui, A. Walters, C. Brooks, L. Pinder, S. Rahman, E. Donnelly, M. Lewell, R. Mellow, C. Hedges, P. Morassutti, R. Bulatovic, E. Galbraith, S. McKenzie, D. Bradford, M. Peddle, A. Dukelow, D. Eby, S. McLeod, G. Fraga, B. Pereira, J. Sareen, M. Doupe, J. Gawaziuk, D. Chateau, S. Logsetty, J. Lewis, D. O’Doherty, S. Hopkins, S. Griffiths, S. Palmer, X. Xu, C. Martin, A. Xenocostas, T. Mele, T. Rui, E. Abreu, M. Andrade, F. Cruz, R. Pires, P. Carreiro, T. Andrade, J. Lampron, F. Balaa, R. Fortuna, H. Issa, P. Dias, M. Marques, T. Fernandes, T. Sousa, K. Inaba, J. Smith, O. Okoye, I. Shulman, J. Nelson, P. Rhee, D. Demetriades, R. Ostrofsky, G. Butler-Laporte, T. Chughtai, K. Khwaja, D. Mulder, T. Razek, D. Deckelbaum, D. Evans, H. Anton, J. Wei, E. Randall, B. Sobolev, B. Ballantyne Scott, R. van Heest, C. Frankfurter, S. McKerracher, N. Merritt, L. Barber, L. Kimmel, C. Hodgson, M. Webb, A. Holland, R. Gruen, K. Harrison, M. Hwang, L. Hsee, I. Civil, A. Muizelaar, F. Baillie, T. Leeper, A. Sutherland, M. Hart, F. Tuma, A. Coates, F. Farrokhyar, S. Faidi, F. Gastaldo, D. Paskar, B. Petrisor, M. Bhandari, W-L Loh, C.D. Ho, C.K. Chong, G. Rodrigues, M. Gissoni, M. Martins, J. Cunha-Melo, S. Rizoli, F. Abu-Zidan, P. Cameron, S. Bernard, T. Walker, D. Jolley, M. Fitzgerald, K. Masci, P. Simpson, K. Smith, S. Cox, A. West, L. Barratt, L. Rozmovits, B. Livingstone, M. Vu, D. Griesdale, R. Schlamp, R. Wand, A. Alrowaili, H. Alghamdi, F. Essbaiheen, J. Chankowsky, M. Stephens, C. Vis, K. Belton, B. Dufresne, J. Guilfoyle, G. Ibbotson, K. Martin, D. Matheson, P. Parks, L. Thomas, A. Kirkpatrick, T. Kline, S. Macey, R. Judson, M. Morgan, S. McLellan, K. Wilson, A. Sorvari, Z. Chaudhry, K. Khawaja, A. Ali, J. Akhtar, M. Zubair, J. Nickow, R. Jaeschke, A. Reintam Blaser, J. Starkopf, D. Zygun, B. Tanenbaum, B. Ribeiro Redondano, L. Simakawa Jimenez, T. Zago, R. Barros de Carvalho, T. Araujo Calderan, S. Campbell, M. Ferri, A. Lashoher, A. McFarlan, N. Ahmed, J. Booy, D. McDowell, A. Nasr, P. Wales, M. Mercado, R. Lall, D. Niven, E. Dixon, G. Kaplan, M. Hameed, M. Qadura, J. Veenstra, P. Hennecke, R. Gardner, L. Appleton, R. Simons, C. Palmer, C. Bevan, J. Crameri, D. Hogan, L. Grealy, A. Chisholm, E. Beairsto, E. Goulette, M. Martin, S. Benjamin, J. Savoie, H. Ondiveeran, K. Doody, D. Leblanc-Duchin, B. Strack, A. Naveed, L. vanRensburg, R. Madan, K. Boulva, G. Verheul, A. Parks, J. Milne, J. Nemeth, J. Correa, B. Bernardin, E. Sproul, A. Mehta, M. Galarneau, P. Mahadevan, V. Bansal, J. Dye, P. Hollingsworth-Fridlund, P. Stout, B. Potenza, R. Coimbra, R. Marley, A. Salvator, D. Pisciotta, J. Bridge, S. Lin, H. Ovens, H. Abdo, R. Dencev-Bihari, A. Lawendy, I. Ibrahim-Zada, V. Pandit, A. Tang, J. Wynne, L. Gries, R. Friese, T. Taulu, H. Wong, A. Saleem, M. Plourde, T. Forbes, G. Martin, K. Gaunt, G. Bandiera, M. Bawazeer, D. MacKinnon, J. Spence, B. Nascimento, H. Aziz, T. O’keeffe, G. Vercruysse, N. Kulvatunyou, J. Sakles, J. Mosier, D. Norman, J. Li, J. Al-Oweis, O. Albuz, E. Karamanos, P. Talving, M. Elhusseini, M. Sudarshan, C. MacPherson, T. Sun, M. Pelletier, M. Abou Khalil, D. Valenti, R. Gelbard, D. Moe, D. Grabo, J. Pasley, P. Teixeira, S.Y. Fung, I. Alababtain, E. Brnjac, L. Luz, P. Parikh, K. Proctor, M. Murtha, C. Schulman, N. Namias, R. Goldman, I. Pike, P. Korn, C. Flett, T. Jackson, J. Keith, T. Joseph, E. Giddins, J.F. Ouellet, M. Cook, M. Schreiber

Publikováno v: Canadian Journal of Surgery. 56:S1-S42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33328e3e1af14aaeba31065cad154987
https://doi.org/10.1503/cjs.005813

Reduced cerebral oxygen saturation measured by absolute cerebral oximetry during thoracic surgery correlates with postoperative complications

Autor: T.M. Hemmerling, D. Bracco, Roy Kazan

Publikováno v: British Journal of Anaesthesia. 103:811-816

Background Regional cerebral oxygen saturation (SctO2) has recently been shown to decrease significantly during thoracic surgery. The present study investigates whether these desaturations are related to postoperative complications. Methods Fifty pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c891a76d2715d2cdd2baff0dc3cedf
https://doi.org/10.1093/bja/aep309

Adenomyosis and Adolescence: A Challenging Diagnosis and Complex Management.

Autor: Martire, Francesco Giuseppe¹ (AUTHOR) francescogmartire@libero.it, d'Abate, Claudia¹ (AUTHOR), Schettini, Giorgia¹ (AUTHOR), Cimino, Giulia¹ (AUTHOR), Ginetti, Alessandro¹ (AUTHOR), Colombi, Irene¹ (AUTHOR), Cannoni, Alberto¹ (AUTHOR), Centini, Gabriele¹ (AUTHOR), Zupi, Errico¹ (AUTHOR) errico.zupi@unisi.it, Lazzeri, Lucia¹ (AUTHOR)

Publikováno v: Diagnostics (2075-4418). Nov2024, Vol. 14 Issue 21, p2344. 15p.