Zobrazeno 1 - 10
of 841
pro vyhledávání: '"D, Binder"'
Publikováno v:
Earth System Science Data, Vol 16, Pp 4103-4118 (2024)
The negative surface mass balance of glaciers and ice caps under a warming climate impacts local ecosystems, influencing the volume and timing of water flow in local catchments while also contributing to global sea level rise. Peripheral glaciers dis
Externí odkaz:
https://doaj.org/article/f78ea04d8f7544d5a3a8c821dffd30d3
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract Objective The IPEC-J2 cell line is used as an in vitro small intestine model for swine, but it is also used as a model for the human intestine, presenting a relatively unique setting. By combining electric cell-substrate impedance sensing, w
Externí odkaz:
https://doaj.org/article/696afcb35ac848cd960b51de796e2794
Autor:
Linda T. Nguyen, Andrea Aprico, Eze Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor J. Kilpatrick, Michele D. Binder
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Background Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and colonise all regions of the CNS early in development. Microglia have been demonstrated to p
Externí odkaz:
https://doaj.org/article/66c5eab9da904e769dbf169a1ab0c23c
Autor:
Alexander D. Walsh, Sarrabeth Stone, Saskia Freytag, Andrea Aprico, Trevor J. Kilpatrick, Brendan R. E. Ansell, Michele D. Binder
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Microglia regulate multiple processes in the central nervous system, exhibiting a considerable level of cellular plasticity which is facilitated by an equally dynamic transcriptional environment. While many gene networks that regulate microg
Externí odkaz:
https://doaj.org/article/38de1b89c4074016a7cfc2ccfcc14aef
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15903 (2023)
Many treatments for autoimmune diseases, caused by the loss of immune self-tolerance, are broadly immunosuppressive. Dendritic cells (DCs) can be induced to develop anti-inflammatory/tolerogenic properties to suppress aberrant self-directed immunity
Externí odkaz:
https://doaj.org/article/c0ef092d48794ae1a08ee4d1da513bcc
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Oscillations in membrane potential induced by synaptic inputs and intrinsic ion channel activity play a role in regulating neuronal excitability, but the precise mechanisms underlying their contributions remain largely unknown. Here we used electroph
Externí odkaz:
https://doaj.org/article/bff3ceb53da04435b404fe3621537bd6
Autor:
Tiago Medeiros-Furquim, Sinan Ayoub, Laura J. Johnson, Andrea Aprico, Eze Nwoke, Michele D. Binder, Trevor J. Kilpatrick
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cladribine (2-chlorodeoxyadenosine, 2CdA) is one of the most effective disease-modifying drugs for multiple sclerosis (MS). Cladribine is a synthetic purine nucleoside analog that induces cell death of lymphocytes and oral cladribine treatment leads
Externí odkaz:
https://doaj.org/article/94ed270034be42b9873adc2296416d2a
Publikováno v:
ASN Neuro, Vol 13 (2021)
Microglia are the resident immune cells of the central nervous system and important regulators of brain homeostasis. Central to this role is a dynamic phenotypic plasticity that enables microglia to respond to environmental and pathological stimuli.
Externí odkaz:
https://doaj.org/article/8dd7ae07bf10401e8fbe4de7bd95d12a
Publikováno v:
Physiol Rev
Ion channels play a central role in the regulation of nearly every cellular process. Dating back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion channels have always been thought of as independent agents. A m
Autor:
Christopher M. Dwyer, Linda Thien-Trang Nguyen, Luke M. Healy, Ranjan Dutta, Samuel Ludwin, Jack Antel, Michele D. Binder, Trevor J. Kilpatrick
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
We propose that multiple sclerosis (MS) is best characterized as a syndrome rather than a single disease because different pathogenetic mechanisms can result in the constellation of symptoms and signs by which MS is clinically characterized. We descr
Externí odkaz:
https://doaj.org/article/5baec7b0bb934dbbb2f805c1e6e474a4