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of 3 428
pro vyhledávání: '"D, Aron"'
Autor:
Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are e
Externí odkaz:
https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e630
Akademický článek
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Autor:
Michelle M Butler, Samanthi L. Waidyarachchi, Jinfeng Shao, Son T. Nguyen, Xiaoyuan Ding, Steven C. Cardinale, Lucas R. Morin, Steven M. Kwasny, Mai Ito, Jeanine Gezelle, Maria B. Jiminez-Diaz, Inigo Angulo-Barturen, Robert T. Jacobs, Jeremy N. Burrows, Zachary D. Aron, Terry L. Bowlin, Sanjay A. Desai
Publikováno v:
Mol Pharmacol
Human and animal malaria parasites increase their host erythrocyte permeability to a broad range of solutes as mediated by parasite-associated ion channels. Molecular and pharmacological studies have implicated an essential role in parasite nutrient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd2cfbfaccb951c5eceaee13a146c87
https://europepmc.org/articles/PMC9450958/
https://europepmc.org/articles/PMC9450958/
Autor:
Atousa Mehrani, Mynthia Cabrera, Kenneth C. Keiler, Michelle M. Butler, Steven M. Kwasny, Pooja Srinivas, Lucas R. Morin, Divya Hosangadi, John N. Alumasa, Jay S. Barbor, Steven C. Cardinale, Scott M. Stagg, Zachary D. Aron, Christine M. Dunham, Ann E. Jerse, Matthew C. Torhan, Timothy J. Opperman, Eric D. Hoffer, Terry L. Bowlin, Kristie L. Connolly
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411f83145a0e100fbdf1e585bbf3dfa6
https://doi.org/10.1038/s41467-021-22012-7
https://doi.org/10.1038/s41467-021-22012-7
Publikováno v:
Drug discovery today. 26(9)
The increasing prevalence of multidrug-resistant (MDR) bacterial infections has created a crucial need for new therapeutics that avoid or minimize existing resistance mechanisms. In this review, we describe the development of novel classes of small-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84f4c5a829015ecb4d8140706acacb4
https://pubmed.ncbi.nlm.nih.gov/33845218
https://pubmed.ncbi.nlm.nih.gov/33845218
Autor:
Jaden Yabut, Donald T. Moir, Bryan J. Berube, Alan R. Hauser, Zachary D. Aron, Terry L. Bowlin, John D. Williams, Giang T. Nguyen, Nicholas O. Bowlin, Debra M. Mills, Joan Mecsas
Publikováno v:
Journal of Bacteriology. 202
The Pseudomonas aeruginosa type III secretion system (T3SS) needle comprised of multiple PscF subunits is essential for the translocation of effector toxins into human cells, facilitating the establishment and dissemination of infection. Mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04c45991ca7b0f3d0c0e6b2ebbabbf31
https://doi.org/10.1128/jb.00055-20
https://doi.org/10.1128/jb.00055-20
Autor:
Divya Hosangadi, Lucas R. Morin, Kristie L. Connolly, Terry L. Bowlin, Michelle M. Butler, Christine M. Dunham, Atousa Mehrani, Zachary D. Aron, Jay S. Barbor, John N. Alumasa, Pooja Srinivas, Kenneth C. Keiler, Eric D. Hoffer, Mynthia Cabrera, Matthew C. Torhan, Scott M. Stagg, Steven M. Kwasny, Timothy J. Opperman, Ann E. Jerse, Steven C. Cardinale
The trans-translation pathway for rescuing stalled ribosomes is conserved and essential in bacterial pathogens but has no mammalian homolog, making it an ideal target for new antibiotics. We previously reported the discovery of a family of acylaminoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c60f516b4139e9bac172634fa60d14b
https://doi.org/10.1101/2020.06.04.132530
https://doi.org/10.1101/2020.06.04.132530
Autor:
Donald T, Moir, Nicholas O, Bowlin, Bryan J, Berube, Jaden, Yabut, Debra M, Mills, Giang T, Nguyen, Zachary D, Aron, John D, Williams, Joan, Mecsas, Alan R, Hauser, Terry L, Bowlin
Publikováno v:
J Bacteriol
The Pseudomonas aeruginosa type III secretion system (T3SS) needle comprised of multiple PscF subunits is essential for the translocation of effector toxins into human cells, facilitating the establishment and dissemination of infection. Mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6ed1fe63674897a027a32524ae665ec
https://pubmed.ncbi.nlm.nih.gov/32601072
https://pubmed.ncbi.nlm.nih.gov/32601072
Publikováno v:
Известия Российской академии наук. Энергетика. :57-69
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d99c01b8c86ca63481984567f6560c4d
https://doi.org/10.31857/s000233100002364-4
https://doi.org/10.31857/s000233100002364-4
Autor:
Theodore C. Willoughby
Publikováno v:
ACM SIGMIS Database: the DATABASE for Advances in Information Systems. 6:32-32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b43a251d289c1dc1858b315d9fad617
https://doi.org/10.1145/1017617.1017622
https://doi.org/10.1145/1017617.1017622