Zobrazeno 1 - 10
of 168
pro vyhledávání: '"D, Aharony"'
Publikováno v:
Journal of Receptor Research. 14:399-421
cDNA clones for NK-2 receptors (NK-2R) were isolated from guinea-pig lung (GPl) and rabbit pulmonary artery (Rpa) using a polymerase chain reaction based methodology. The GPl NK-2R consists of 402 amino acids and encodes a protein with a relative mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02593c2bb346f0b8ed24f5aaea23e9a9
https://doi.org/10.3109/10799899409101512
https://doi.org/10.3109/10799899409101512
Autor:
W L, Rumsey, D, Aharony, R A, Bialecki, B M, Abbott, H G, Barthlow, R, Caccese, S, Ghanekar, D, Lengel, M, McCarthy, B, Wenrich, B, Undem, C, Ohnmacht, A, Shenvi, J S, Albert, F, Brown, P R, Bernstein, K, Russell
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(1)
The tachykinins, substance P, neurokinin A, and neurokinin B, have been implicated in many diseases. The present study evaluated the pharmacological properties of a novel tachykinin antagonist ZD6021 [3-cyano-N-((2S)-2-(3,4-dichlorophenyl)-4-[4-[2-(m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ead071d78eeb5f7f2b56a413e03c6ef
https://pubmed.ncbi.nlm.nih.gov/11408556
https://pubmed.ncbi.nlm.nih.gov/11408556
Autor:
D, Aharony, C K, Buckner, J L, Ellis, S V, Ghanekar, A, Graham, J S, Kays, J, Little, S, Meeker, S C, Miller, B J, Undem
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(3)
We examined the pharmacology of ZM253,270 and two representative examples of the pyrrolopyrimidines, a new class of nonpeptide, NK-2 receptor (NK-2R) antagonists. ZM253,270 competitively inhibited [3H]NKA binding to native or cloned NK-2R from hamste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53af57f22932db570fe1cd0baa94823b
https://pubmed.ncbi.nlm.nih.gov/7562491
https://pubmed.ncbi.nlm.nih.gov/7562491
Publikováno v:
Receptorschannels. 2(4)
With the goal of obtaining sufficient functional protein for structural analysis, rat neurokinin-2 receptor was produced in Escherichia coli by linking it to the periplasmic maltose-binding protein. As a first step, we present a biochemical and pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::705963672223fe8ad8532a3e1c822538
https://pubmed.ncbi.nlm.nih.gov/7719707
https://pubmed.ncbi.nlm.nih.gov/7719707
Publikováno v:
Molecular pharmacology. 45(1)
Functional cDNA clones for hamster neurokinin-2 receptor (NK-2R) were isolated from hamster urinary bladder using a polymerase chain reaction-based methodology. The hamster NK-2R consists of 384 amino acids with a relative molecular weight of 43,418.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1ec74af3c5bffe8d3406a43b0adc460
https://pubmed.ncbi.nlm.nih.gov/8302285
https://pubmed.ncbi.nlm.nih.gov/8302285
Autor:
R C, Falcone, S J, Hubbs, J D, Vanderloo, J C, Prosser, J, Little, B, Gomes, D, Aharony, R D, Krell
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(3)
Specific binding of [3H]bradykinin (BK) to guinea pig gall bladder (GPGB) membranes was protein dependent, rapid (Kon = 0.067 min-1) with high affinity (Kd = 0.45 +/- 0.02; n = 3), saturable (Bmax = 546 +/- 56 fmol/mg of protein) and showed no cooper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a9ed2cc2a1e0bfc2e68d40fc29ef594
https://pubmed.ncbi.nlm.nih.gov/8396632
https://pubmed.ncbi.nlm.nih.gov/8396632
Autor:
D, Aharony, J, Little, S, Powell, B, Hopkins, K R, Bundell, W L, McPheat, R D, Gordon, G, Hassall, R, Hockney, R, Griffin
Publikováno v:
Molecular pharmacology. 44(2)
Using the novel ligand [4,5-3H-Leu9]neurokinin A ([4,5-3H-Leu9] NKA) in a receptor binding assay, we characterized the pharmacology of a cloned neurokinin NK-2 receptor from human lung (hNK-2R), expressed in baculovirus-infected Sf-21 insect cells. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d18b8c80e6f81064430b3e319314ae5f
https://pubmed.ncbi.nlm.nih.gov/8394992
https://pubmed.ncbi.nlm.nih.gov/8394992
Publikováno v:
Neuropeptides. 23(2)
We synthesized a novel ligand [4,5-3H-Leu9]-Neurokinin A (3H-NKA, S.A 117-144 Ci/mmol), and evaluated its binding to hamster urinary bladder membranes (HUBM). The ligand bound to HUBM in a highly-specific (94 +/- 4%) and protein-dependent manner. Bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27bbf257d100096c24a62b4d234425dc
https://pubmed.ncbi.nlm.nih.gov/1333574
https://pubmed.ncbi.nlm.nih.gov/1333574
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 259(1)
A novel ligand, [4,5-3H-Leu10]substance P ([3H]SP), with high specific activity (137 Ci/mmole) was utilized to investigate the properties of NK (neurokinin)-1 receptors on guinea pig lung membranes (GPLM) and compared them to NK-1 receptors on rat su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::435f32c01213e2f9a0474c678f7900e1
https://pubmed.ncbi.nlm.nih.gov/1717678
https://pubmed.ncbi.nlm.nih.gov/1717678
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 258(1)
The effects of peptidoleukotrienes (LTs) on electrically driven guinea pig left atria (GPLA) were investigated. LTD4 produced a positive inotropic response; however, rapid desensitization required the construction of noncumulative dose-response curve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca4b8e6f0963ba350e4f70a6bdee2c22
https://pubmed.ncbi.nlm.nih.gov/1649293
https://pubmed.ncbi.nlm.nih.gov/1649293