Zobrazeno 1 - 10
of 144
pro vyhledávání: '"D'Orazio, Vittorio"'
Autor:
Ensieh Poursani, Giuseppe Cirillo, Manuela Curcio, Orazio Vittorio, Michele De Luca, Antonella Leggio, Fiore Pasquale Nicoletta, Francesca Iemma
Publikováno v:
International Journal of Pharmaceutics: X, Vol 7, Iss , Pp 100235- (2024)
In this study, we developed self-assembling nanoparticles (LCPs) able to trigger the release of Chlorambucil (Chl) and Doxorubicin (DOX) to MDA-MB-231 cells by exploiting the enzyme and redox signals. The DOX loaded LCPs was prepared by the self-asse
Externí odkaz:
https://doaj.org/article/cb289e5ace8b4da3acbb7b9211893337
Autor:
Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters, Tyler Shai-Hee, Riccardo Cazzoli, Merryn Brettle, Iveta Slapetova, Maria Kasherman, Renee Whan, Fernando Souza-Fonseca-Guimaraes, Linda Vahdat, David Ziegler, John G. Lock, Federico M. Giorgi, KumKum Khanna, Orazio Vittorio
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicated in cancer progressi
Externí odkaz:
https://doaj.org/article/b17391f9a29d4891bcdc6914896812f8
Autor:
Mariagrazia Di Luca, Ensieh Poursani, Manuela Curcio, Giuseppe Cirillo, Antonietta Salerno, Sara Bolognini, Giovanni De Filpo, Sara Filippi, Orazio Vittorio, Francesca Iemma, Fiore Pasquale Nicoletta
Publikováno v:
Macromolecular Materials and Engineering, Vol 308, Iss 11, Pp n/a-n/a (2023)
Abstract With the objective of creating an electro‐responsive and antimicrobial device suitable as delivery system for Rose Bengal (RB) to the skin, a hybrid hydrogel combining Chitosan (CS) and Graphene Oxide (GO) are designed, serving as function
Externí odkaz:
https://doaj.org/article/d235f4b8a29246fabb428ecfcf58e789
Autor:
Chelsea Mayoh, Andrew J. Gifford, Rachael Terry, Loretta M. S. Lau, Marie Wong, Padmashree Rao, Tyler Shai-Hee, Federica Saletta, Dong-Anh Khuong-Quang, Vicky Qin, Marion K. Mateos, Deborah Meyran, Katherine E. Miller, Aysen Yuksel, Emily V. A. Mould, Rachel Bowen-James, Dinisha Govender, Akanksha Senapati, Nataliya Zhukova, Natacha Omer, Hetal Dholaria, Frank Alvaro, Heather Tapp, Yonatan Diamond, Luciano Dalla Pozza, Andrew S. Moore, Wayne Nicholls, Nicholas G. Gottardo, Geoffrey McCowage, Jordan R. Hansford, Seong-Lin Khaw, Paul J. Wood, Daniel Catchpoole, Catherine E. Cottrell, Elaine R. Mardis, Glenn M. Marshall, Vanessa Tyrrell, Michelle Haber, David S. Ziegler, Orazio Vittorio, Joseph A. Trapani, Mark J. Cowley, Paul J. Neeson, Paul G. Ekert
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a
Externí odkaz:
https://doaj.org/article/fbd7979e6f4b4aebb70a711623639d1f
Autor:
Riccardo Cazzoli, Francesco Romeo, Isabella Pallavicini, Sebastiano Peri, Mauro Romanenghi, Juan Alberto Pérez-Valencia, Eman Hagag, Filippo Ferrucci, Mohamed Elgendy, Orazio Vittorio, Salvatore Pece, Marco Foiani, Jukka Westermarck, Saverio Minucci
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112616- (2023)
Summary: Combined inhibition of oxidative phosphorylation (OXPHOS) and glycolysis has been shown to activate a PP2A-dependent signaling pathway, leading to tumor cell death. Here, we analyze highly selective mitochondrial complex I or III inhibitors
Externí odkaz:
https://doaj.org/article/2e89761a53e748da9ba4ce42a1fbb8c9
Autor:
Katelin M. Allan, Miro A. Astore, Egi Kardia, Sharon L. Wong, Laura K. Fawcett, Jessica L. Bell, Simone Visser, Po-Chia Chen, Renate Griffith, Adam Jaffe, Sheila Sivam, Orazio Vittorio, Serdar Kuyucak, Shafagh A. Waters
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: Cystic fibrosis (CF) is caused by a wide spectrum of mutations in the CF transmembrane conductance regulator (CFTR) gene, with some leading to non-classical clinical presentations. We present an integrated in vivo, in silico and in vitro
Externí odkaz:
https://doaj.org/article/983bc3fd05834594ba1500ce3059b03f
Autor:
Jake Nowicki, Michael P Brown, Tessa Gargett, Lisa M Ebert, Nga T H Truong, Paris M Kollis, Kristyna Sedivakova, Wenbo Yu, Erica C F Yeo, Nicole L Wittwer, Briony L Gliddon, Melinda N Tea, Rebecca Ormsby, Santosh Poonnoose, Orazio Vittorio, David S Ziegler, Stuart M Pitson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Aggressive primary brain tumors such as glioblastoma are uniquely challenging to treat. The intracranial location poses barriers to therapy, and the potential for severe toxicity. Effective treatments for primary brain tumors are limited,
Externí odkaz:
https://doaj.org/article/aeb6b5a8c73041bf87654aafeab489d5
Autor:
Rajesh Kuppusamy, Muhammad Yasir, Tsz Tin Yu, Florida Voli, Orazio Vittorio, Michael J. Miller, Peter Lewis, David StC Black, Mark Willcox, Naresh Kumar
Publikováno v:
Antibiotics, Vol 12, Iss 3, p 585 (2023)
There is a pressing need to develop new antimicrobials to help combat the increase in antibiotic resistance that is occurring worldwide. In the current research, short amphiphilic antibacterial and antibiofilm agents were produced by tuning the hydro
Externí odkaz:
https://doaj.org/article/7e6a6aceea644ab5b17e529e28105b80
Autor:
Manuela Curcio, Orazio Vittorio, Jessica Lilian Bell, Francesca Iemma, Fiore Pasquale Nicoletta, Giuseppe Cirillo
Publikováno v:
Nanomaterials, Vol 12, Iss 16, p 2851 (2022)
Self-assembling nanoparticles (SANPs) based on hyaluronic acid (HA) represent unique tools in cancer therapy because they combine the HA targeting activity towards cancer cells with the advantageous features of the self-assembling nanosystems, i.e.,
Externí odkaz:
https://doaj.org/article/4d67d38408ce41fba781299790a71fc0
Autor:
Anahid Ehteda, Sandy Simon, Laura Franshaw, Federico M. Giorgi, Jie Liu, Swapna Joshi, Jourdin R.C. Rouaen, Chi Nam Ignatius Pang, Ruby Pandher, Chelsea Mayoh, Yujie Tang, Aaminah Khan, Caitlin Ung, Ornella Tolhurst, Anne Kankean, Elisha Hayden, Rebecca Lehmann, Sylvie Shen, Anjana Gopalakrishnan, Peter Trebilcock, Katerina Gurova, Andrei V. Gudkov, Murray D. Norris, Michelle Haber, Orazio Vittorio, Maria Tsoli, David S. Ziegler
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108994- (2021)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (
Externí odkaz:
https://doaj.org/article/f3c43c1ed6e44cbd8f4c250a0e00921a