TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

Autor: Gratuze, Maud, Schlachetzki, Johannes C.M., D’Oliveira Albanus, Ricardo, Jain, Nimansha, Novotny, Brenna, Brase, Logan, Rodriguez, Lea, Mansel, Clayton, Kipnis, Michal, O’Brien, Sydney, Pasillas, Martina P., Lee, Choonghee, Manis, Melissa, Colonna, Marco, Harari, Oscar, Glass, Christopher K., Ulrich, Jason D., Holtzman, David M.

Publikováno v: In Neuron 18 January 2023 111(2):202-219

MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state

Autor: You, Shih-Feng, Brase, Logan, Filipello, Fabia, Iyer, Abhirami K., Del-Aguila, Jorge, He, June, D’Oliveira Albanus, Ricardo, Budde, John, Norton, Joanne, Gentsch, Jen, Dräger, Nina M., Sattler, Sydney M., Kampmann, Martin, Piccio, Laura, Morris, John C., Perrin, Richard J., McDade, Eric, Paul, Steven M., Cashikar, Anil G., Benitez, Bruno A., Harari, Oscar, Karch, Celeste M.

Publikováno v: medRxiv

Genome-wide association studies (GWAS) have identified many modifiers of Alzheimer disease (AD) risk enriched in microglia. Two of these modifiers are common variants in theMS4Alocus (rs1582763: protective and rs6591561: risk) and serve as major regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9df348a71bd2637b3b42a46e2a1ecb3
https://europepmc.org/articles/PMC9934804/

Microglia transcriptional heterogeneity across human and experimental models.

Autor: Garg, Anjali, Novotny, Brenna C, D'Oliveira Albanus, Ricardo, Brase, Logan, Karch, Celeste M., Morris, John C, Perrin, Richard J., Sutherland, Greg T, Benitez, Bruno A., Harari, Oscar

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 12, Vol. 19, p1-2, 2p

An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals.

Autor: Zhao Z; Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.; Center for Genomic Health, Weill Cornell Medicine, 1300 York Ave, New York, NY 15 10065, USA., D'Oliveira Albanus R; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Taylor H; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Tang X; Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.; Center for Genomic Health, Weill Cornell Medicine, 1300 York Ave, New York, NY 15 10065, USA., Han Y; Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.; Center for Genomic Health, Weill Cornell Medicine, 1300 York Ave, New York, NY 15 10065, USA., Orchard P; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Varshney A; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Zhang T; Stem Cell Research Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA., Manickam N; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Erdos M; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Narisu N; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Taylor L; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Saavedra X; Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA., Zhong A; Genomic Resource Core Facility, Weill Cornell Medical College, NY 10065, USA., Li B; Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA., Zhou T; Genomic Resource Core Facility, Weill Cornell Medical College, NY 10065, USA., Naji A; Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA19104, USA., Liu C; Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA19104, USA., Collins F; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Parker SC; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Chen S; Department of Surgery, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.; Center for Genomic Health, Weill Cornell Medicine, 1300 York Ave, New York, NY 15 10065, USA.

Publikováno v: Research square [Res Sq] 2023 Oct 18. Date of Electronic Publication: 2023 Oct 18.

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.

Autor: DiCorpo D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Gaynor SM; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA., Russell EM; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Westerman KE; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, 02114, USA.; Metabolism Program, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA., Majarian TD; Metabolism Program, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA., Wu P; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Highland HM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA., Jackson A; Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA., Hasbani NR; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Brody JA; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.; Department of Medicine, University of Washington, Seattle, WA, 98101, USA., Hidalgo B; Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Perry JA; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Lent S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA., Jain D; Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA., Wang H; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA., D'Oliveira Albanus R; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Varshney A; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Yanek LR; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Lange L; Department of Medicine, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO, 80045, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Almeida M; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA., Peralta JM; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA., Aslibekyan S; 23andMe, Sunnyvale, CA, 94086, USA., Baldridge AS; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Bertoni AG; Department of Epidemiology & Prevention, Wake Forest School of Medicine, Winston-, Salem, NC, 27157, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Chen CS; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Choi WJ; Psomagen, Inc, Rockville, MD, 20850, USA., Goodarzi MO; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Floyd JS; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine, University of Washington, Seattle, WA, 98195, USA., Irvin MR; Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Kalyani RR; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Kelly TN; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA., Lee S; Psomagen, Inc, Rockville, MD, 20850, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Loesch D; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Manson JE; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Brigham and Women's Hospital, Boston, MA, 02115, USA., Minster RL; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Naseri T; Ministry of Health, Government of Samoa, Apia, Samoa., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA., Reupena MS; Lutia i Puava 'ae Mapu i Fagalele, Apia, Samoa., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21287, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Weeks DE; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Xu H; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Parker S; Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA., Arnett DK; College of Public Health, University of Kentucky, Lexington, KY, 40506, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA., Boerwinkle E; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39211, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.; National Heart Lung and Blood Institute and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA., Duggirala R; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville and Edinburg, TX, 78539, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA., Heckbert SR; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Kim RW; Psomagen, Inc, Rockville, MD, 20850, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Liu S; Center for Global Cardiometabolic Health (CGCH), Boston, MA, 02215, USA., Mathias RA; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., McGarvey ST; International Health Institute and Department of Epidemiology, Brown University School of Public Health, Providence, RI, 02912, USA., Mitchell BD; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; Geriatrics Research and Education Clinical Center, Baltimore VA Medical Center, Baltimore, MD, 21201, USA., Morrison AC; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.; Department of Medicine, University of Washington, Seattle, WA, 98101, USA.; Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA.; Department of Health Services, University of Washington, Seattle, WA, 98101, USA., Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA., Shuldiner AR; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, 21231, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Vasan RS; National Heart Lung and Blood Institute and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA.; Evans Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, 02118, USA.; Evans Department of Medicine, Whitaker Cardiovascular Institute and Cardiology Section, Boston University School of Medicine, Boston, MA, 02118, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina, Inc, San Diego, CA, 92122, USA., Florez JC; Metabolism Program, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA.; Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, 02114, USA., Wilson JG; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA., Sladek R; Department of Human Genetics, McGill University, Montreal, Montreal, Quebec, H3A 0G1, Canada.; Department of Medicine, McGill University, Montreal, Montreal, Quebec, H3A 0G1, Canada., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Lin X; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Meigs JB; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Wessel J; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, IN, 46202, USA. wesselj@iu.edu.; Department of Medicine, School of Medicine, Indiana University, IN, 46202, USA. wesselj@iu.edu.; Diabetes Translational Research Center, Indiana University, IN, 46202, USA. wesselj@iu.edu., Manning AK; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, 02114, USA. amanning@broadinstitute.org.; Metabolism Program, The Broad Institute of MIT and Harvard, Cambridge, MA, 02124, USA. amanning@broadinstitute.org.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA. amanning@broadinstitute.org.

Publikováno v: Communications biology [Commun Biol] 2022 Jul 28; Vol. 5 (1), pp. 756. Date of Electronic Publication: 2022 Jul 28.