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Analysis of Acinetobacter P-type type IV secretion system-encoding plasmid diversity uncovers extensive secretion system conservation and diverse antibiotic resistance determinants.

Autor: Oke MT; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., Martz K; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., Mocăniță M; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., Knezevic S; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., D'Costa VM; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Dec 05; Vol. 68 (12), pp. e0103824. Date of Electronic Publication: 2024 Nov 04.

Functional Divergence of the Paralog Salmonella Effector Proteins SopD and SopD2 and Their Contributions to Infection.

Autor: Oke MT; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1H 8M5, Canada., D'Costa VM; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 10; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 10.

Targeting CD73 with flavonoids inhibits cancer stem cells and increases lymphocyte infiltration in a triple-negative breast cancer mouse model.

Autor: Mediratta K; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., El-Sahli S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Marotel M; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Awan MZ; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; Department of Biotechnology, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan., Kirkby M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Salkini A; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Kurdieh R; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Abdisalam S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Shrestha A; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Di Censo C; Ottawa Hospital Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Sulaiman A; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada.; Department of Pathology, John Hopkins University School of Medicine, Baltimore, MD, United States., McGarry S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada., Lavoie JR; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Liu Z; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China., Lee SH; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada., Li X; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Sir Frederick G. Banting Research Centre, Ottawa, ON, Canada., Sciumè G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.; Instituto Pasteur Italia - Fondazione Cenci Bolognetti, Roma, Italy., D'Costa VM; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada., Ardolino M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Wang L; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.; The Centre for Infection, Immunity, and Inflammation (CI3), University of Ottawa, Ottawa, ON, Canada.; China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine-University of Ottawa, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Mar 27; Vol. 15, pp. 1366197. Date of Electronic Publication: 2024 Mar 27 (Print Publication: 2024).

Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10.

Autor: Boddy KC; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Zhu H; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., D'Costa VM; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Canada., Xu C; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., Beyrakhova K; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., Cygler M; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., Grinstein S; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Coyaud E; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Laurent EMN; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., St-Germain J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Brumell JH; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada. john.brumell@sickkids.ca.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. john.brumell@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. john.brumell@sickkids.ca.; SickKids IBD Centre, Hospital for Sick Children, Toronto, ON, Canada. john.brumell@sickkids.ca.

Publikováno v: Nature communications [Nat Commun] 2021 Aug 04; Vol. 12 (1), pp. 4707. Date of Electronic Publication: 2021 Aug 04.