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Development of Novel Imipridones with Alkyne- and Triazole-Linked Warheads on the Tricyclic Skeleton, Showing Superior Ability to Eradicate PANC-1 and Fadu Cells Compared to ONC201.

Autor: Czuczi T; Department of Organic Chemistry, Eötvös Loránd University (ELTE), Pázmány P. Sétány 1/A, H-1117 Budapest, Hungary.; Hevesy György PhD School of Chemistry, Pázmány P. Sétány 1/A, H-1117 Budapest, Hungary., Murányi J; Department of Organic Chemistry, Eötvös Loránd University (ELTE), Pázmány P. Sétány 1/A, H-1117 Budapest, Hungary., Móra I; Department of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary., Gurbi B; Department of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary., Varga A; Department of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary., Papp D; Hevesy György PhD School of Chemistry, Pázmány P. Sétány 1/A, H-1117 Budapest, Hungary.; MTA-ELTE Lendület (Momentum) Ion Mobility Mass Spectrometry Research Group, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter Sétány 1/A, H-1117 Budapest, Hungary., Schlosser G; MTA-ELTE Lendület (Momentum) Ion Mobility Mass Spectrometry Research Group, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter Sétány 1/A, H-1117 Budapest, Hungary., Csala M; Department of Molecular Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary., Csámpai A; Department of Organic Chemistry, Eötvös Loránd University (ELTE), Pázmány P. Sétány 1/A, H-1117 Budapest, Hungary.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 07; Vol. 25 (23). Date of Electronic Publication: 2024 Dec 07.