Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants.

Autor: Appay, V, Brown, A, Cribbes, S, Randle, E, Czaplewski, L G

Publikováno v: Journal of Biological Chemistry; September 1999, Vol. 274 Issue: 39 p27505-12, 8p

Chemical modification of a variant of human MIP-1alpha; implications for dimer structure.

Autor: Ashfield JT; School of Chemistry, University of Leeds, United Kingdom., Meyers T, Lowne D, Varley PG, Arnold JR, Tan P, Yang JC, Czaplewski LG, Dudgeon T, Fisher J

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2000 Oct; Vol. 9 (10), pp. 2047-53.

A randomized phase-II study of BB-10010 (macrophage inflammatory protein- 1alpha) in patients with advanced breast cancer receiving 5-fluorouracil, adriamycin, and cyclophosphamide chemotherapy.

Autor: Clemons MJ; CRC Department of Medical Oncology and Paterson Institute for Cancer Research, Christie Hospital, Manchester; ICRF Clinical Oncology Unit, Guy's Hospital, London., Marshall E, Dürig J, Watanabe K, Howell A, Miles D, Earl H, Kiernan J, Griffiths A, Towlson K, DeTakats P, Testa NG, Dougal M, Hunter MG, Wood LM, Czaplewski LG, Millar A, Dexter TM, Lord BI

Publikováno v: Blood [Blood] 1998 Sep 01; Vol. 92 (5), pp. 1532-40.

The effects of human macrophage inflammatory protein-1 alpha and its genetically modified variant, BB10010, on phagocyte function.

Autor: Williams SL; Department of Haematology, University College London Medical School, UK., Addison IE, Mollapour E, Czaplewski LG, Linch DC, Roberts PJ

Publikováno v: Cytokines, cellular & molecular therapy [Cytokines Cell Mol Ther] 1997 Mar; Vol. 3 (1), pp. 41-50.

The effect of the chemokine rhMIP-1 alpha, and a non-aggregating variant BB-10010, on blast cells from patients with acute myeloid leukaemia.

Autor: Owen-Lynch PJ; Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester., Adams JA, Brereton ML, Czaplewski LG, Whetton AD, Yin JA

Publikováno v: British journal of haematology [Br J Haematol] 1996 Oct; Vol. 95 (1), pp. 77-84.