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Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41

Autor: Evan F. Haney, Leonard T. Nguyen, David J. Schibli, Hans J. Vogel

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1172-1184 (2012)

A number of physicochemical characteristics have been described which contribute to the biological activity of antimicrobial peptides. This information was used to design a novel antimicrobial peptide sequence by using an intrinsically inactive membr

Externí odkaz: https://doaj.org/article/70db31122836432f8e3b21dcd17e15fd

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide

Autor: Rik J. Scheper, Sue Ellen Verbrugge, Yehuda G. Assaraf, Huib Ovaa, Gerrit Jansen, Robert H. Shoemaker, Godefridus J. Peters, Rob H. Meloen, Ruud Oerlemans, Celia R. Berkers, George L. Scheffer, Jacqueline Cloos, Jerry W. Slootstra, Ben A. C. Dijkmans

Publikováno v: Investigational New Drugs
Oerlemans, R, Berkers, C R, Assaraf, Y G, Scheffer, G L, Peters, G J, Verbrugge, S E, Cloos, J, Slootstra, J, Meloen, R H, Shoemaker, R H, Dijkmans, B A C, Scheper, R J, Ovaa, H & Jansen, G 2018, ' Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide ', Investigational New Drugs, vol. 36, no. 5, pp. 797-809 . https://doi.org/10.1007/s10637-018-0569-x
Investigational New Drugs, 36(5), 797-809. Kluwer Academic Publishers
Investigational New Drugs, 36(5), 797-809

Summary Background The hexapeptide 4A6 (Ac-Thr(tBu)-His(Bzl)-Thr(Bzl)-Nle-Glu(OtBu)-Gly-Bza) was isolated from a peptide library constructed to identify peptide-based transport inhibitors of multidrug resistance (MDR) efflux pumps including P-glycopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51de26c79f798655a697b79404426de5
http://www.scopus.com/inward/record.url?scp=85041905364&partnerID=8YFLogxK

An enzymatic assay based on luciferase Ebola virus-like particles for evaluation of virolytic activity of antimicrobial peptides

Autor: Vojtech Adam, Petr Janda, Marie Peskova, Vladimir Pekarik, Zbynek Heger

Publikováno v: Peptides

Graphical abstract The membrane impermeable luciferase substrate furimazine is outside of the virus-like particles while the reporter enzyme is enclosed inside the viral membrane. While the membrane is intact, the substrate remains separated from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce91ad5a615fd0366b2a333e479f3bd
https://doi.org/10.1016/j.peptides.2016.12.015

Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions

Autor: Saeid Ghavami, Claus Kerkhoff, Fatemeh Karami-Tehrani, Clemens Sorg, Mohammad Hashemi, Marek Los

Publikováno v: Journal of Leukocyte Biology. 76:169-175

The protein complex S100A8/A9, abundant in the cytosol of neutrophils, is secreted from the cells upon cellular activation and induces apoptosis in tumor cell lines and normal fibroblasts in a zinc-reversible manner. In the present study, we present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db919151412a4f8a2ec523dfc8ed6d8
https://doi.org/10.1189/jlb.0903435