Výsledky vyhledávání - "Cytotoxic RNase"

Akademický článek

Zeolites as Carriers of Antitumor Ribonuclease Binase

Autor: Vera Khojaewa, Oleg Lopatin, Pavel Zelenikhin, Olga Ilinskaya

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Natural and synthetic zeolites have many applications in biomedicine and nutrition. Due to its properties, zeolites can absorb therapeutically active proteins and release them under physiological conditions. In this study we tested the clinoptilolite

Externí odkaz: https://doaj.org/article/1b7fbe84ac70428786ee8b688531c7fa

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Zeolites as Carriers of Antitumor Ribonuclease Binase

Autor: Pavel V. Zelenikhin, Olga N. Ilinskaya, O.N. Lopatin, Vera Khojaewa

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 10 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dc894a9511b9f1d87ff73ec2beeb6f

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Binase treatment increases interferon sensitivity and apoptosis in SiHa cervical carcinoma cells by downregulating E6 and E7 human papilloma virus oncoproteins

Autor: Irina Yu. Petrushanko, Vladimir A. Mitkevich, K. M. Burnysheva, Alexey A. Schulga, Alexei A. Adzhubei, Peter M. Chumakov, Alexander A. Makarov

Publikováno v: Oncotarget

In this study, we determined whether binase, a ribonuclease from Bacillus pumilus, increases interferon sensitivity and apoptosis in SiHa cervical cancer cells infected with high-risk human papilloma virus (HPV) strain 16. Binase treatment increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb20ebb0fd9724b130cf93e32ab65b7
https://pubmed.ncbi.nlm.nih.gov/29069817

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The multiple forms of bovine seminal ribonuclease: Structure and stability of a C-terminal swapped dimer

Autor: Delia Picone, Andrea Pica, Filomena Sica, Antonello Merlino, Irene Russo Krauss, Carmine Ercole

Publikováno v: FEBS Letters. 587:3755-3762

Bovine seminal ribonuclease (BS-RNase) acquires an interesting anti-tumor activity associated with the swapping on the N-terminal. The first direct experimental evidence on the formation of a C-terminal swapped dimer (C-dimer) obtained from the monom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8904423ecbfb05662aaeb0ef1483b2
https://doi.org/10.1016/j.febslet.2013.10.003

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Akademický článek

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Internalization of Bacillus intermedius ribonuclease (BINASE) induces human alveolar adenocarcinoma cell death

Autor: Cabrera-Fuentes H., Aslam M., Saffarzadeh M., Kolpakov A., Zelenikhin P., Preissner K., Ilinskaya O.

Publikováno v: SCOPUS00410101-2013-69-SID84878478484

Ribonuclease (RNase) treatment represents a novel mechanism based approach to anticancer therapy as an alternative to the DNA damaging drugs commonly used in clinical practice. Apart from their ribonucleolytic activity, cytotoxic effects have attract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::04c6acc55f96d4bd5ca94be3c998c001
https://openrepository.ru/article?id=47667

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Ribonuclease binase apoptotic signature in leukemic Kasumi-1 cells

Autor: Mitkevich V., Kretova O., Petrushanko I., Burnysheva K., Sosin D., Simonenko O., Ilinskaya O., Tchurikov N., Makarov A.

Publikováno v: SCOPUS03009084-2013-95-6-SID84877765977

Cytotoxic exogenous RNases triggering apoptotic response in malignant cells have potential as anticancer drugs; surprisingly, detailed characterization of the RNase-induced apoptosis has not been conducted so far. Here we show that a cytotoxic RNase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3c965af5509871f51093c8f3366875f9
https://openrepository.ru/article?id=207906

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Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and AML1-ETO oncogenes

Autor: Mitkevich V., Petrushanko I., Spirin P., Fedorova T., Kretova O., Tchurikov N., Prassolov V., Ilinskaya O., Makarov A.

Publikováno v: SCOPUS15384101-2011-10-23-SID82855169516

Some RNases selectively attack malignant cells, triggering an apoptotic response and therefore are considered as alternative chemotherapeutic drugs. Here, we studied the effects of Bacillus intermedius RNase (binase) on murine myeloid progenitor cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5bed9c108690edcbc1a257cc7b2be584
https://openrepository.ru/article?id=209261

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Akademický článek

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Oncogenic c-kit transcript is a target for binase

Autor: Mitkevich V., Petrushanko I., Kretova O., Spirin P., Zelenikhin P., Prassolov V., Tchurikov N., Ilinskaya O., Makarov A.

Publikováno v: SCOPUS15384101-2010-9-13-SID77955437455

Mutational activation of c-Kit receptor tyrosine kinase is common in acute myelogenous leukemia. One such activating point mutation is the N822K replacement in the c-Kit protein. Here we investigate the selective cytotoxic effect of binase - RNase fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::668a2ab42323003a9fc1e638e21f19c4
https://openrepository.ru/article?id=209258

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