Zobrazeno 1 - 10 of 50 pro vyhledávání: '"Cytostatin"'
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Akademický článek
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3
The potent protein phosphatase 2A inhibitors aminocytostatins: new derivatives of cytostatin
Autor: Shigehiro Tohyama, Masayuki Igarashi, Kazuaki Matoba, Ryuichi Sawa, Hiroyuki Inoue, Hideyuki Muramatsu, Manabu Kawada, Masaki Hatano
Publikováno v: The Journal of Antibiotics. 74:743-751
Specific inhibitors of protein phosphatase 2A (PP2A) mediate anticancer effects by augmenting the tumor-killing activity of natural killer (NK) cells. In this study, new PP2A inhibitors, aminocytostatins A-E, were isolated from Kitasatospora sp. MJ65
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a8fc0c7f04e778cc7813ab4e5b6fdf
https://doi.org/10.1038/s41429-021-00455-w
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4
Synthetic studies toward cytostatin, a natural product inhibitor of protein phosphatase 2A
Autor: Anne-Frédérique Salit, Christophe Meyer, Benedicte Delouvrie, Janine Cossy, Laurent Francois Andre Hennequin
Publikováno v: Tetrahedron. 64:6684-6697
Synthetic approaches toward the natural product cytostatin, an inhibitor of protein phosphatase 2A possessing cytotoxic and antimetastatic activities, have been investigated. A formal synthesis of cytostatin has been achieved according to a strategy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8c4db4c9c27d7657434d4c76af7c970
https://doi.org/10.1016/j.tet.2008.05.012
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5
Formal Synthesis of Cytostatin by a Convergent Approach
Autor: Christophe Meyer, Janine Cossy, Anne-Frédérique Salit
Publikováno v: Synlett. 2007:0934-0938
A formal synthesis of cytostatin, an antitumor agent, has been achieved according to a convergent approach involving the coupling of a functionalized organolithium (C1-C8 subunit) with an aldehyde (C9-C13 subunit).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41b3fe70da2ba49ca76e838851840245
https://doi.org/10.1055/s-2007-970786
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6
Synthetic Studies on Fostriecin and Related Natural Products
Autor: Kazuyuki Miyashita, Tomoyuki Tsunemi, Masahiro Ikejiri, Ayumi Matsumoto, Takeshi Imanishi
Publikováno v: Journal of Synthetic Organic Chemistry, Japan. 65:874-887
Fostriecin (CI-920), isolated from Streptomyces pulveraceus, shows in vitro antitumor activity against leukemia, lung breast and ovarian cancer, and in vivo against L 1210 and P 388 leukemia. Its analogous compounds, such as leustroducsins, phoslacto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b42bb7362a43991024bec13b0dc88323
https://doi.org/10.5059/yukigoseikyokaishi.65.874
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9
Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A
Autor: Masaaki Ishizuka, Tomio Takeuchi, Masahide Amemiya, Manabu Kawada
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1452(2):209-217
Cytostatin, which is isolated from a microbial cultured broth as a low molecular weight inhibitor of cell adhesion to extracellular matrix (ECM), has anti-metastatic activity against B16 melanoma cells in vivo. In this study, we examined a target of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f293e53cd228005edf32f669fad74c7
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10
Applications of chiral allenylzinc additions and Noyori asymmetric reductions to an enantioselective synthesis of a C3–C13 precursor of the polyketide phosphatase inhibitor cytostatin
Autor: Keith C. Ellis, James A. Marshall
Publikováno v: Tetrahedron Letters. 45:1351-1353
A 12-step synthesis of a C3–C13 precursor of the protein phosphatase inhibitor cytostatin is described. Key stereocenters were introduced by a chiral allenylzinc addition and Noyori asymmetric-transfer hydrogenation.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::998c1a9d10867b112d9ae5c24d57b1d8
https://doi.org/10.1016/j.tetlet.2003.12.067
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