Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Cytosolic DNA"'
Autor:
Conghui Xu, Weiyao Jing, Cui Liu, Bo Yuan, Xinghua Zhang, Limei Liu, Fengfan Zhang, Ping Chen, Qiang Liu, Haidong Wang, Xiaozheng Du
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Rheumatoid arthritis is a chronic autoimmune disease of undetermined etiology characterized by symmetric synovitis with predominantly destructive and multiple joint inflammation. Cytoplasmic DNA sensors that recognize protein molecules that are not t
Externí odkaz:
https://doaj.org/article/c05ef3bcd7454847b9012aca1265d132
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 678-699 (2024)
Abstract Cytosolic DNA sensors are a group of pattern recognition receptors (PRRs) that vary in structures, molecular mechanisms, and origins but share a common function to detect intracellular microbial DNA and trigger the innate immune response lik
Externí odkaz:
https://doaj.org/article/dc14c998a1a94601ba06e7c1c0ec4fc8
Autor:
Dianne W. Xu, Michelle D. Tate
Publikováno v:
Viruses, Vol 16, Iss 10, p 1535 (2024)
Influenza A viruses (IAV) are dynamic and highly mutable respiratory pathogens that present persistent public health challenges. Inflammasomes, as components of the innate immune system, play a crucial role in the early detection and response to infe
Externí odkaz:
https://doaj.org/article/300a7a7160fd4ae4ba752f8f0a759fec
Publikováno v:
Pharmacological Research, Vol 200, Iss , Pp 107079- (2024)
The AIM2 inflammasome represents a multifaceted oligomeric protein complex within the innate immune system, with the capacity to perceive double-stranded DNA (dsDNA) and engage in diverse physiological reactions and disease contexts, including cancer
Externí odkaz:
https://doaj.org/article/74ef71f974584448b53ae9e736cbb75e
Autor:
Vila, Isabelle K., Laguette, Nadine
Publikováno v:
Comptes Rendus Biologies, Vol 346, Iss G1, Pp 29-33 (2023)
Detection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. In the past decade, the stimulator of interferon genes (STING) adaptor protein has emerged as a central platform enabling the activation of
Externí odkaz:
https://doaj.org/article/3879728821814a27a8959c346380d2aa
Autor:
Qiyuan Zhuang, Chaxian Liu, Yihan Hu, Ying Liu, Yingying Lyu, Yuheng Liao, Liang Chen, Hui Yang, Ying Mao
Publikováno v:
MedComm, Vol 4, Iss 6, Pp n/a-n/a (2023)
Abstract Human gliomas are lethal brain cancers. Emerging evidence revealed the regulatory role of long noncoding RNAs (lncRNAs) in tumors. Here, we performed a comprehensive analysis of the expression profiles of RNAs in histologically lower‐grade
Externí odkaz:
https://doaj.org/article/1f8cc3e629de40b28264854ac5a191c1
Autor:
Zhi Huan Chew, Jianzhou Cui, Karishma Sachaphibulkij, Isabelle Tan, Shreya Kar, Kai Kiat Koh, Kritika Singh, Hong Meng Lim, Soo Chin Lee, Alan Prem Kumar, Stephan Gasser, Lina H. K. Lim
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Intracellular recognition of self and non-self -nucleic acids can result in the initiation of effective pro-inflammatory and anti-tumorigenic responses. We hypothesized that macrophages can be activated by tumor-derived nucleic acids to induce inflam
Externí odkaz:
https://doaj.org/article/0e7c66659b314a1588999179baf5069b
Autor:
Seoyul Lee, Wookyeom Yang, Dae Kyoung Kim, Hojun Kim, Minjoo Shin, Kyung Un Choi, Dong Soo Suh, Yun Hak Kim, Tae-Ho Hwang, Jae Ho Kim
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 211-224 (2022)
Oncolytic vaccinia virus (OVV) has been reported to induce cell death in various types of cancer; however, the oncolytic activity of OVV in drug-resistant ovarian cancer remains limited. In the present study, we established doxorubicin-resistant ovar
Externí odkaz:
https://doaj.org/article/93132df63ce44f5d9daa3ff59bf93fef
Autor:
Daniela Fioretti, Mario Ledda, Sandra Iurescia, Raffaella Carletti, Cira Di Gioia, Maria Grazia Lolli, Rodolfo Marchese, Antonella Lisi, Monica Rinaldi
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 30 (2023)
Background: The regeneration of severe traumatic muscle injuries is an unsolved medical need that is relevant for civilian and military medicine. In this work, we produced a critically sized nonhealing muscle defect in a mouse model to investigate mu
Externí odkaz:
https://doaj.org/article/7deac05d873241c4acaf2179df0f5207
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Base excision repair (BER) has evolved to maintain the genomic integrity of DNA following endogenous and exogenous agent induced DNA base damage. In contrast, aberrant BER induces genomic instability, promotes malignant transformation and can even tr
Externí odkaz:
https://doaj.org/article/56074cafe5154dc99906152b3216da25